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Cyclic GMP (CID 24316) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Unspecified(12)
 
 
Top Targets:
ABCC MRP doma..(8)
 
 
CAP ED(3)
 
 
MFS(1)
 
 
BioAssay Types:
Literature(16)
 
 
 
BioActivity Types:
EC50(3)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 16    Data Row: 16   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103526857]
IC50 0.1Inhibition of bovine arterial Phosphodiesterase 3 [AID159198, Type: Literature]
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2
[SID103526857]
IC50 2.4Inhibition of canine heart Phosphodiesterase 3 [AID159203, Type: Literature]
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3
[SID103526857]
Activation of olfactory CNG A2A41b channel expressed in HEK293 cells assessed as effect on half maximal current [AID297178, Type: Literature]
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4
[SID103526857]
Activation of retinal rod olfactory CNG A1B1 channel expressed in Xenopus oocytes assessed as effect on half maximal current [AID297179, Type: Literature]
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5
[SID103526857]
EC50 1GRAC: human CNGA2 activator [AID540671, Type: Literature]Cyclic nucleotide-gated olfactory channel [gi:119370323]
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6
[SID103526857]
Km 2.1TP_TRANSPORTER: uptake in membrane vesicles from MRP5-expressing V79 cells [AID680352, Type: Literature]Multidrug resistance-associated protein 5 [gi:8928547]
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7
[SID103526857]
Km 9.69TP_TRANSPORTER: uptake in membrane vesicles from MRP4-expressing Sf9 cells [AID679496, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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8
[SID103526857]
EC50 30GRAC: human CNGA1 activator [AID540791, Type: Literature]cGMP-gated cation channel alpha-1 [gi:239938910]
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9
[SID103526857]
EC50 30GRAC: human CNGA3 activator [AID540628, Type: Literature]Cyclic nucleotide-gated cation channel alpha-3 [gi:13959682]
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10
[SID103526857]
TP_TRANSPORTER: inhibition of Estradiol-17beta-D-glucuronide uptake by cGMP at a concentration of 10 uM in membrane vesicle from MRP8-expressing LLC-PK1 cells [AID680604, Type: Literature]ATP-binding cassette sub-family C member 11 [gi:74762666]
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11
[SID103526857]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: Literature]Solute carrier family 22 member 6 [gi:81886651]
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12
[SID103526857]
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 30 uM, Zaprinast: 100uM) in MRP4-expressing HEK293 cells [AID680357, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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13
[SID103526857]
Substrates of transporters of clinical importance in the absorption and disposition of drugs, MRP4 [AID588979, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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14
[SID103526857]
TP_TRANSPORTER: inhibition of alaninyl-d4TMP uptake (alaninyl-d4TMP: 1 uM, Zaprinast: 100uM) in MRP5-expressing HEK293 cells [AID680353, Type: Literature]Multidrug resistance-associated protein 5 [gi:8928547]
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15
[SID103526857]
TP_TRANSPORTER: inhibition of MTX uptake (MTX: 20 uM, cGMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells [AID681904, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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16
[SID103526857]
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 1 uM, cGMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells [AID681922, Type: Literature]Multidrug resistance-associated protein 4 [gi:206729914]
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