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Benzoic Acid (CID 243) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(688)
 
 
Inconclusive(19)
 
 
Unspecified(194)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(27)
 
 
 
NR LBD PPAR(21)
 
 
 
NR LBD ER(18)
 
 
 
 
 
NR LBD AR(17)
 
 
 
 
BioAssay Types:
Confirmatory(369)
 
 
 
 
 
Screening(260)
 
 
 
Literature(76)
 
 
 
 
Summary(48)
 
 
 
BioActivity Types:
Potency(359)
 
 
 
 
 
IC50(130)
 
 
 
 
Ki(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 782    Data Row: 914   Total Pages: 19   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176121]
IC50 0.2Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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2
[SID144209601]
Potency-Replicate_1 5.0987qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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3
[SID103176121]
Ki 7Inhibition of human recombinant DAO expressed in Escherichia coli BL21(DE3) by oxygraphic assay [AID726204, Type: Literature]D-amino-acid oxidase [gi:25453448]
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4
[SID103176121]
Ki 10.9Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by Lineweaver-Burk plot analysis [AID726213, Type: Literature]D-amino-acid oxidase [gi:25453448]
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5
[SID103176121]
Ki 13.8038Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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6
[SID103176121]
Ki 37.5Inhibition of human recombinant N-terminal His-tagged DAO Y224A mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis [AID726214, Type: Literature]
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7
[SID103176121]
IC50 46.9Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-serine as substrate by colorimetric assay [AID726222, Type: Literature]D-amino-acid oxidase [gi:25453448]
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8
[SID103176121]
Competitive inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by Lineweaver-Burk plot analysis [AID726216, Type: Literature]D-amino-acid oxidase [gi:25453448]
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9
[SID103176121]
Binding affinity to human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) at 40 uM after 2 to 30 mins by absorption spectra analysis [AID726218, Type: Literature]D-amino-acid oxidase [gi:25453448]
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10
[SID46392055]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Crystal Structure Of Ydce, A 4-Oxalocrotonate Tautomerase Homologue From Escherichia Coli, Confirms The Structural Basis For Oligomer Diversity [gi:24987272]
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11
[SID46392378]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Nitroreductase From E. Cloacae Complex With Inhibitor Benzoate [gi:20150964]
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12
[SID85272320]
DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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13
[SID103176121]
Stability at pH 7.4 at 80 uM during 1 day by HPLC in presence of linoleic acid and azo-bis-isobutyronitrile [AID430001, Type: Literature]
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14
[SID103176121]
Km 3.05TP_TRANSPORTER: uptake in MCT1-expressing MDA-MB231 cells [AID679949, Type: other]Monocarboxylate transporter 1 [gi:1709076]
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15
[SID103176121]
Ki 54Inhibition of human recombinant N-terminal His-tagged DAO Y224F mutant expressed in Escherichia coli BL21(DE3) using D-alanine as substrate after 10 mins by Lineweaver-Burk plot analysis [AID726215, Type: Literature]
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16
[SID103176121]
IC50 65.7Inhibition of human recombinant N-terminal His-tagged DAO expressed in Escherichia coli BL21(DE3) using D-alanine as substrate by colorimetric assay [AID726221, Type: Literature]D-amino-acid oxidase [gi:25453448]
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17
[SID103176121]
Ki 251.189Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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18
[SID103176121]
MIC 327.86Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID403754, Type: Literature]
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19
[SID103176121]
Ki 3800Inhibition of ADCS [AID274670, Type: Literature]
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20
[SID103176121]
MIC 5000Antifungal activity against Cochliobolus lunatus [AID404686, Type: Literature]
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21
[SID103176121]
IC50 10000Inhibition of human recombinant N-terminal His-tagged serine racemase expressed in Escherichia coli BL21(DE3) using L-serine as substrate after 10 mins by fluorescence assay [AID726220, Type: Literature]Serine racemase [gi:20139924]
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22
[SID103176121]
IC50 10000Inhibition of human recombinant N-terminal His-tagged DDO expressed in Escherichia coli BL21(DE3) using D-aspartate as substrate by colorimetric assay [AID726223, Type: Literature]D-aspartate oxidase [gi:2494037]
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23
[SID103176121]
IC50 14200Inhibition of pieris rapae Phenoloxidase [AID293934, Type: Literature]
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24
[SID103176121]
IC50 16600Hydroxyl radical scavanging activity by chemiluminescence technique in mouse thymus cells [AID114585, Type: Literature]
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25
[SID103176121]
In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration [AID147482, Type: Literature]
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26
[SID103176121]
Lysozyme-conjugated prodrugs: in vitro stability at pH 5 [AID197596, Type: Literature]
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27
[SID103176121]
Lysozyme-conjugated prodrugs: in vitro stability at pH 7.4 [AID197598, Type: Literature]
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28
[SID103176121]
Lysozyme-conjugated prodrugs: in vitro stability in rat cortical homogenate at pH 5 [AID197600, Type: Literature]
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29
[SID103176121]
Lysozyme-conjugated prodrugs: in vitro stability in rat cortical homogenate at pH 7.4 [AID197602, Type: Literature]
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30
[SID103176121]
Lysozyme-conjugated prodrugs: in vitro stability in buffered plasma at pH 7.4 [AID197730, Type: Literature]
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31
[SID103176121]
Hammett constant was determined [AID226477, Type: Literature]
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32
[SID103176121]
Hammett constant was evaluated [AID226478, Type: Literature]
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33
[SID103176121]
Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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34
[SID103176121]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1B radioligand binding (ligand: [125I] Cyanopindolol) [AID625191, Type: other]5-hydroxytryptamine receptor 1B [gi:112815]
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35
[SID103176121]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2C radioligand binding (ligand: [3H] Mesulergine) [AID625218, Type: other]5-hydroxytryptamine receptor 2C [gi:112816]
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36
[SID103176121]
IC50 DRUGMATRIX: Acetylcholinesterase enzyme inhibition (substrate: acetylthiocholine) [AID625193, Type: other]Acetylcholinesterase [gi:113037]
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37
[SID103176121]
IC50 DRUGMATRIX: Muscarinic M1 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625151, Type: other]Muscarinic acetylcholine receptor M1 [gi:113118]
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38
[SID103176121]
IC50 DRUGMATRIX: Muscarinic M2 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625152, Type: other]Muscarinic acetylcholine receptor M2 [gi:113122]
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39
[SID103176121]
IC50 DRUGMATRIX: Muscarinic M3 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625153, Type: other]Muscarinic acetylcholine receptor M3 [gi:113125]
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40
[SID103176121]
IC50 DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone) [AID625228, Type: other]Androgen receptor [gi:113832]
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41
[SID103176121]
IC50 DRUGMATRIX: Monoamine Oxidase MAO-A enzyme inhibition (substrate: Kynuramine) [AID625150, Type: other]Amine oxidase [flavin-containing] A [gi:113978]
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42
[SID103176121]
IC50 DRUGMATRIX: Carbonic Anhydrase II enzyme inhibition (substrate: 4-Nitrophenyl acetate (4-NPA)) [AID625236, Type: other]Carbonic anhydrase 2 [gi:115456]
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43
[SID103176121]
IC50 DRUGMATRIX: Cannabinoid CB1 radioligand binding (ligand: [3H] SR141716A) [AID625235, Type: other]Cannabinoid receptor 1 [gi:115562]
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44
[SID103176121]
IC50 DRUGMATRIX: Protease, Cathepsin G enzyme inhibition (substrate: Suc-Ala-Ala-Pro-Phe-AMC) [AID625175, Type: other]Cathepsin G [gi:115725]
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45
[SID103176121]
IC50 DRUGMATRIX: Peptidase, Matrix Metalloproteinase-1 (MMP-1) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625177, Type: other]Interstitial collagenase [gi:116852]
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46
[SID103176121]
IC50 DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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47
[SID103176121]
IC50 DRUGMATRIX: CYP450, 2E1 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625250, Type: other]Cytochrome P450 2E1 [gi:117250]
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48
[SID103176121]
IC50 DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) [AID625253, Type: other]D(2) dopamine receptor [gi:118206]
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49
[SID103176121]
IC50 DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390) [AID625252, Type: other]D(1A) dopamine receptor [gi:118228]
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50
[SID103176121]
DRUGMATRIX: Peptidase, ELA2 (Neutrophil Elastase 2) enzyme inhibition (substrate: N-MeOSuc-Ala-Ala-Pro-Val-pNA) [AID625176, Type: other]Neutrophil elastase [gi:119292]
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