Benzoic Acid (CID 243) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(459)
 
 
Inconclusive(4)
 
 
Unspecified(190)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(16)
 
 
 
p450(10)
 
 
 
NR LBD PPAR(5)
 
 
BRLZ(4)
 
 
BioAssay Types:
Screening(217)
 
 
 
Confirmatory(217)
 
 
 
 
Literature(66)
 
 
 
 
BioActivity Types:
Potency(172)
 
 
 
 
IC50(126)
 
 
 
 
Ki(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 649    Data Row: 659   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103176121]
IC50 0.2Antihemorrhagic activity in ddY mouse assessed as inhibition of Protobothrops flavoviridis venom-induced hemorrhagic lesion formation compound incubated with venom for 10 mins and administered subcutaneously measured after 24 hrs [AID631927, Type: Literature]
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2
[SID103176121]
Ki 13.8038Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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3
[SID85272320]
 DENV2 CPE-Based HTS Measured in Cell-Based and Microorganism Combination System Using Plate Reader - 2149-01_Other_SinglePoint_HTS_Activity [AID651640, Type: screening]
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4
[SID46392378]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Structure Of Nitroreductase From E. Cloacae Complex With Inhibitor Benzoate [gi:20150964]
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5
[SID46392055]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, The Crystal Structure Of Ydce, A 4-Oxalocrotonate Tautomerase Homologue From Escherichia Co [gi:24987272]
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6
[SID103176121]
 Stability at pH 7.4 at 80 uM during 1 day by HPLC in presence of linoleic acid and azo-bis-isobutyronitrile [AID430001, Type: Literature]
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7
[SID103176121]
Km 3.05TP_TRANSPORTER: uptake in MCT1-expressing MDA-MB231 cells [AID679949, Type: other]Monocarboxylate transporter 1 [gi:1709076]
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8
[SID103176121]
Ki 251.189Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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9
[SID103176121]
MIC 327.86Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID403754, Type: Literature]
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10
[SID103176121]
Ki 3800Inhibition of ADCS [AID274670, Type: Literature]
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11
[SID103176121]
MIC 5000Antifungal activity against Cochliobolus lunatus [AID404686, Type: Literature]
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12
[SID103176121]
IC50 14200Inhibition of pieris rapae Phenoloxidase [AID293934, Type: Literature]
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13
[SID103176121]
IC50 16600Hydroxyl radical scavanging activity by chemiluminescence technique in mouse thymus cells [AID114585, Type: Literature]
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14
[SID103176121]
 In vitro inhibitory activity against H1N9 strain of Influenza neuraminidase (membrane) at 7 mM concentration [AID147482, Type: Literature]
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15
[SID103176121]
 Lysozyme-conjugated prodrugs: in vitro stability at pH 5 [AID197596, Type: Literature]
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16
[SID103176121]
 Lysozyme-conjugated prodrugs: in vitro stability at pH 7.4 [AID197598, Type: Literature]
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17
[SID103176121]
 Lysozyme-conjugated prodrugs: in vitro stability in rat cortical homogenate at pH 5 [AID197600, Type: Literature]
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18
[SID103176121]
 Lysozyme-conjugated prodrugs: in vitro stability in rat cortical homogenate at pH 7.4 [AID197602, Type: Literature]
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19
[SID103176121]
 Lysozyme-conjugated prodrugs: in vitro stability in buffered plasma at pH 7.4 [AID197730, Type: Literature]
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20
[SID103176121]
 Hammett constant was determined [AID226477, Type: Literature]
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21
[SID103176121]
 Hammett constant was evaluated [AID226478, Type: Literature]
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22
[SID103176121]
 Lipophilicity determined as logarithm of the partition coefficient in the alkane/water system [AID237685, Type: Literature]
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23
[SID103176121]
 Aqueous solubility [AID19262, Type: Literature]
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24
[SID103176121]
 Partition coefficient (logP) (chloroform) [AID23254, Type: Literature]
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25
[SID103176121]
 Partition coefficient (logP) (ether) [AID23255, Type: Literature]
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26
[SID103176121]
 Partition coefficient (logP) (hexane) [AID23256, Type: Literature]
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27
[SID103176121]
 log (1/C') was determined [AID28666, Type: Literature]
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28
[SID103176121]
 log LD50 was determined [AID28691, Type: Literature]
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29
[SID103176121]
 Concentration of the drug in the kidney of rat [AID28692, Type: Literature]
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30
[SID103176121]
 Concentration of the drug in the liver of rat [AID28693, Type: Literature]
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31
[SID103176121]
 Partition coefficient (logD2.0) [AID28731, Type: Literature]
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32
[SID103176121]
 Partition coefficient (logP) (hexadecane) [AID28921, Type: Literature]
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33
[SID103176121]
 Effective permeability corrected for ionization [AID28926, Type: Literature]
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34
[SID103176121]
 Intrinsic permeability of the compound [AID28928, Type: Literature]
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35
[SID103176121]
 Inhibitory activity against murine gelatinase B at 5 mM was determined [AID74488, Type: Literature]
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36
[SID103176121]
 Dissociation constant, pKa of the compound [AID302815, Type: Literature]
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37
[SID103176121]
 Partition coefficient, log P of the compound [AID310931, Type: Literature]
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38
[SID103176121]
 Permeability across human Skin [AID310932, Type: Literature]
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39
[SID103176121]
 Permeability across PAMPA membrane after 7 hrs [AID310933, Type: Literature]
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40
[SID103176121]
 Lipophilicity, log P of the compound [AID311366, Type: Literature]
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41
[SID103176121]
 Permeability coefficient in human skin [AID311367, Type: Literature]
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42
[SID103176121]
 Dissociation constant, pKa of the compound [AID342464, Type: Literature]
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43
[SID103176121]
 Binding affinity to beta cyclodextrin [AID346025, Type: Literature]
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44
[SID103176121]
 Partition coefficient (logP) [AID23251, Type: Literature]
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45
[SID103176121]
 Partition coefficient (logP) (benzene) [AID23252, Type: Literature]
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46
[SID103176121]
 Partition coefficient (logP) (carbon tetrachloride) [AID23253, Type: Literature]
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47
[SID103176121]
 Ratio of pKi for mouse Oat1 expressed in Xenopus oocytes to pKi for mouse Oat6 expressed in Xenopus oocytes [AID360151, Type: Literature]
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48
[SID103176121]
 Dissociation constant, pKa of the compound [AID371730, Type: Literature]
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49
[SID103176121]
 Intrinsic aqueous solubility at pH 10 by shake-flask method [AID384955, Type: Literature]
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50
[SID103176121]
 Inhibition of soybean 15-lipoxygenase [AID385427, Type: Literature]
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