T0515-8425 (CID 2423595) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(34)
 
 
Inactive(537)
 
 
Inconclusive(26)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(9)
 
 
KCNQ channel(8)
 
 
 
DUF3371(7)
 
 
 
BioAssay Types:
Screening(390)
 
 
 
 
 
Confirmatory(192)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(129)
 
 
 
 
 
IC50(39)
 
 
 
EC50(13)
 
 
 
AC50(7)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 599    Data Row: 599   Total Pages: 12   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID22408699]
IC50 0.72673Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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2
[SID22408699]
EC50 0.73E3 Ligase_Mutant_Dose Response [AID1442, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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3
[SID22408699]
EC50 0.73E3 Ligase_Mutant_Dose Response [AID1442, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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4
[SID22408699]
IC50 0.80423Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID651672, Type: confirmatory]PLIN1 gene product [Homo sapiens] [gi:223718203]
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5
[SID22408699]
EC50 0.94E3 Ligase dose-response_384 [AID1394, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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6
[SID22408699]
EC50 0.94E3 Ligase dose-response_384 [AID1394, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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7
[SID22408699]
IC50 1.088Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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8
[SID22408699]
IC50 1.506Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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9
[SID22408699]
IC50 1.506Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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10
[SID22408699]
IC50 1.506Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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11
[SID22408699]
EC50 1.65E3 Ligase_WT_Dose Response [AID1444, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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12
[SID22408699]
EC50 1.65E3 Ligase_WT_Dose Response [AID1444, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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13
[SID22408699]
EC50 3.15092High throughput discovery of novel modulators of ROMK K+ channel activity: Dose-Response Assay [AID2753, Type: confirmatory]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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14
[SID22408699]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]
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15
[SID22408699]
Potency 10qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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16
[SID22408699]
Potency 11.2202VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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17
[SID22408699]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]
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18
[SID22408699]
Potency 12.5893qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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19
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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20
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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21
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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22
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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23
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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24
[SID22408699]
AC50 12.652MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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25
[SID22408699]
Potency 14.581qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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26
[SID22408699]
Potency 19.9526qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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27
[SID22408699]
Potency 20.5962A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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28
[SID22408699]
Potency 20.5962qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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29
[SID22408699]
Potency 25.1189qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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30
[SID22408699]
Potency 25.1189qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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31
[SID22408699]
Potency 25.1189qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase) [AID894, Type: confirmatory]15-hydroxyprostaglandin dehydrogenase [NAD+] isoform 1 [Homo sapiens] [gi:31542939]
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32
[SID22408699]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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33
[SID22408699]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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34
[SID22408699]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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35
[SID22408699]
Potency 35.4813Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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36
[SID22408699]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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37
[SID22408699]
 MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
38
[SID22408699]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
View
39
[SID22408699]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
View
40
[SID22408699]
 Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651674, Type: screening]HNF4A gene product [Homo sapiens] [gi:31077205]
View
41
[SID22408699]
 Specificity screen against KCNQ1 for compounds that potentiate KCNQ2 potassium channels [AID2283, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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42
[SID22408699]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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43
[SID22408699]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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44
[SID22408699]
 High throughput discovery of novel modulators of ROMK K+ channel activity: Retest of Primary Hits [AID1917, Type: other]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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45
[SID22408699]
 E3 Ligase HTS_1536 [AID1230, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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46
[SID22408699]
 E3 Ligase HTS_1536 [AID1230, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
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47
[SID22408699]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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48
[SID22408699]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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49
[SID22408699]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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50
[SID22408699]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
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