MLS000834598 (CID 23930866) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(22)
 
 
Inactive(363)
 
 
Inconclusive(6)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
7TM GPCR Srsx(5)
 
 
TRP 2(5)
 
 
zf-H2C2 2(4)
 
 
 
alkPPc(4)
 
 
BioAssay Types:
Screening(307)
 
 
 
 
Confirmatory(78)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(54)
 
 
 
 
 
IC50(18)
 
 
 
EC50(4)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 392    Data Row: 392   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49640635]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID49640635]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID49640635]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID49640635]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID49640635]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID49640635]
Potency 1.2995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID49640635]
IC50 1.37Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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8
[SID49640635]
Potency 1.5849qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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9
[SID49640635]
Potency 1.5849qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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10
[SID49640635]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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11
[SID49640635]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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12
[SID49640635]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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13
[SID49640635]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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14
[SID49640635]
Potency 4.1095A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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15
[SID49640635]
EC50 10.547Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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16
[SID49640635]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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17
[SID49640635]
 Single concentration confirmation of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435020, Type: screening]
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18
[SID49640635]
 uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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19
[SID49640635]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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20
[SID49640635]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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21
[SID49640635]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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22
[SID49640635]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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23
[SID49640635]
 Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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24
[SID49640635]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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25
[SID49640635]
 Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]Breast cancer type 1 susceptibility protein [gi:728984]
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26
[SID49640635]
 Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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27
[SID49640635]
 Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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28
[SID49640635]
 Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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29
[SID49640635]
 Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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30
[SID49640635]
 Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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31
[SID49640635]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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32
[SID49640635]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
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33
[SID49640635]
 Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells [AID624413, Type: screening]
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34
[SID49640635]
 HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
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35
[SID49640635]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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36
[SID49640635]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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37
[SID49640635]
Potency 2.2387qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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38
[SID49640635]
Potency 2.2387qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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39
[SID49640635]
EC50 60Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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40
[SID49640635]
IC50 80Dose response cytotoxicity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489026, Type: confirmatory]
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41
[SID49640635]
IC50 80Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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42
[SID49640635]
IC50 80Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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43
[SID49640635]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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44
[SID49640635]
EC50 Screen for small molecule probes relevant to Friedreich's ataxia, Single Dose and Dose Response [AID1465, Type: confirmatory]
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45
[SID49640635]
 Rml C and D inhibition 384-well mixture HTS [AID1532, Type: screening]
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46
[SID49640635]
 MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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47
[SID49640635]
IC50 A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus [AID1621, Type: confirmatory]
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48
[SID49640635]
IC50 High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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49
[SID49640635]
 MLPCN Platelet Activation -Dense Granule Release [AID1663, Type: screening]
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50
[SID49640635]
 uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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