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beta-Alanine (CID 239) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Inactive(133)
 
 
Inconclusive(2)
 
 
Unspecified(15)
 
 
Top Targets:
p450(9)
 
 
PLDc mTdp1 2(6)
 
 
PanC(5)
 
 
 
Tubulin-bindi..(5)
 
 
HSD10-like SD..(4)
 
 
BioAssay Types:
Confirmatory(122)
 
 
 
Literature(17)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(99)
 
 
 
IC50(5)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 116    Data Row: 154   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103224450]
IC50 11.6Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes. [AID143615, Type: Literature]
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2
[SID103224450]
IC50 21.8776Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells [AID595475, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:341942004]
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3
[SID103224450]
IC50 34.6737Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in human HEK cells [AID595476, Type: Literature]
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4
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase by tryptophan fluorescence quenching assay [AID603208, Type: Literature]Pantothenate synthetase [gi:61229569]
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5
[SID103224450]
IC50 331.131Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells [AID595474, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400623]
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6
[SID103224450]
Ki 2400Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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7
[SID103224450]
IC50 2570.4Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cells [AID595473, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:47117844]
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8
[SID103224450]
Concentration required for obtaining 50% of the fluorescence intensity of copper-free calcein 1, in bovine serum albumin at 10 mM concentration [AID51035, Type: Literature]
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9
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as alpha-helix structural changes by circular dichroism spectra analysis (Rvb = 47.93 %%) [AID603203, Type: Literature]Pantothenate synthetase [gi:61229569]
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10
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as beta-sheet structural changes by circular dichroism spectra analysis (Rvb = 8.19 %%) [AID603204, Type: Literature]Pantothenate synthetase [gi:61229569]
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11
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as alpha-helix structural changes by crystal structure analysis (Rvb = 41.3 %%) [AID603205, Type: Literature]Pantothenate synthetase [gi:61229569]
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12
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase assessed as beta-sheet structural changes by crystal structure analysis (Rvb = 21.3 %%) [AID603206, Type: Literature]Pantothenate synthetase [gi:61229569]
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13
[SID103224450]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681145, Type: other]SLC16A10 protein [gi:121945115]
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14
[SID103224450]
Cleavage rate against hairpin ribozyme at 2 mM, in presence of 0.5 uM magnesium ions [AID198301, Type: Literature]
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15
[SID103224450]
Cleavage rate against hairpin ribozyme at 5 mM with 0.5 uM magnesium ions [AID198302, Type: Literature]
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16
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 1 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255579, Type: Literature]
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17
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 3 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255581, Type: Literature]
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18
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 10 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255583, Type: Literature]
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19
[SID11113405]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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20
[SID11113405]
Potency 2.9935Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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21
[SID26751644]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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22
[SID11113405]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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23
[SID11113405]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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24
[SID11113405]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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25
[SID11113405]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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26
[SID26751644]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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27
[SID26751644]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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28
[SID11113405]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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29
[SID11113405]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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30
[SID11113405]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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31
[SID26751644]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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32
[SID11113405]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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33
[SID11113405]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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34
[SID11113405]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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35
[SID11113405]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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36
[SID11113405]
Potency qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide [AID1766, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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37
[SID11113405]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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38
[SID26751644]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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39
[SID11113405]
Potency qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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40
[SID26751644]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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41
[SID26751644]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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42
[SID26751644]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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43
[SID11113405]
Potency Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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44
[SID11113405]
GR-GFP Redistribution [AID450, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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45
[SID11113405]
GR-EFC Redistribution [AID451, Type: confirmatory]glucocorticoid receptor isoform gamma [Homo sapiens] [gi:66528677]
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46
[SID11113405]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF [AID1454, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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47
[SID11113405]
Potency qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay [AID995, Type: confirmatory]mitogen-activated protein kinase 1 [Homo sapiens] [gi:66932916]
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48
[SID11113405]
Cytochrome panel assay with activity outcomes [AID1851_2, Type: other]cytochrome P450 2D6 isoform 2 [Homo sapiens] [gi:68509921]
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49
[SID11113405]
Cytochrome panel assay with activity outcomes [AID1851_4, Type: other]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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50
[SID11113405]
p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450 1A2 [Homo sapiens] [gi:73915100]
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