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beta-Alanine (CID 239) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(133)
 
 
Inconclusive(2)
 
 
Unspecified(19)
 
 
Top Targets:
p450(9)
 
 
PLDc mTdp1 2(6)
 
 
Tubulin-bindi..(5)
 
 
HSD10-like SD..(4)
 
 
NR LBD TR(4)
 
 
BioAssay Types:
Confirmatory(122)
 
 
 
Literature(25)
 
 
 
Screening(1)
 
 
BioActivity Types:
Potency(99)
 
 
 
IC50(11)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 123    Data Row: 161   Total Pages: 9   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103224450]
IC50 11.6Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 of rat spinal cord membranes. [AID143615, Type: Literature]
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2
[SID103224450]
IC50 21.8776Inhibition of GABA uptake at murine GAT-2 expressed in HEK293 cells [AID759053, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400623]
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3
[SID103224450]
IC50 21.8776Inhibition of mouse GAT3-mediated [3H]GABA uptake expressed in human HEK cells [AID595475, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:341942004]
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4
[SID103224450]
IC50 34.6737Inhibition of mouse GAT4-mediated [3H]GABA uptake expressed in human HEK cells [AID595476, Type: Literature]
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5
[SID103224450]
IC50 34.6737Inhibition of GABA uptake at murine GAT-3 expressed in HEK293 cells [AID759054, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:341942004]
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6
[SID103224450]
IC50 41.2Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis [AID764976, Type: Literature]Sodium- and chloride-dependent GABA transporter 3 [gi:1352531]
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7
[SID103224450]
Binding affinity to Mycobacterium tuberculosis pantothenate synthetase by tryptophan fluorescence quenching assay [AID603208, Type: Literature]Pantothenate synthetase [gi:614101224]
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8
[SID103224450]
IC50 209Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis [AID764977, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:209572724]
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9
[SID103224450]
IC50 331.131Inhibition of mouse GAT2-mediated [3H]GABA uptake expressed in human HEK cells [AID595474, Type: Literature]Sodium- and chloride-dependent GABA transporter 2 [gi:400623]
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10
[SID103224450]
IC50 331.131Inhibition of GABA uptake at murine BGT-1 expressed in HEK293 cells [AID759055, Type: Literature]Sodium- and chloride-dependent betaine transporter [gi:400627]
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11
[SID103224450]
Ki 2400Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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12
[SID103224450]
IC50 2570.4Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cells [AID595473, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:47117844]
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13
[SID103224450]
IC50 2818.38Inhibition of GABA uptake at murine GAT-1 expressed in HEK293 cells [AID759056, Type: Literature]Sodium- and chloride-dependent GABA transporter 1 [gi:47117844]
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14
[SID103224450]
pKa (acid-base dissociation constant) as determined by Morgenthaler ref: ChemMedChem 2007 [AID781327, Type: Literature]
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15
[SID103224450]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681145, Type: Literature]SLC16A10 protein [gi:121945115]
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16
[SID103224450]
Cleavage rate against hairpin ribozyme at 2 mM, in presence of 0.5 uM magnesium ions [AID198301, Type: Literature]
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17
[SID103224450]
Cleavage rate against hairpin ribozyme at 5 mM with 0.5 uM magnesium ions [AID198302, Type: Literature]
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18
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 1 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255579, Type: Literature]
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19
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 3 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255581, Type: Literature]
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20
[SID103224450]
Percent inhibition of CD40 expression in BCL1 cells treated with 10 uM peptide nucleic acid (PNA)conjugate; n=3 [AID255583, Type: Literature]
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