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T0512-2958 (CID 2376815) - Compound BioActivity Data
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BioActivity Outcomes:
Active(84)
 
 
Inactive(623)
 
 
Inconclusive(43)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
 
SWIB(8)
 
 
BioAssay Types:
Screening(486)
 
 
 
 
Confirmatory(246)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(61)
 
 
 
 
EC50(22)
 
 
 
 
AC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 682    Data Row: 751   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24836573]
EC50 0.221Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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2
[SID24836573]
EC50_uM 0.38Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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3
[SID24836573]
EC50 0.38E3 Ligase dose-response_384 [AID1394, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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4
[SID24836573]
Mean Wild-type EC50 0.48E3 Ligase_WT_Dose Response [AID1444, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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5
[SID24836573]
IC50 0.67Luminescent dose response cell-based high throughput screening assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1691, Type: confirmatory]
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6
[SID24836573]
EC50 1.343Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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7
[SID24836573]
IC50 1.5Luminescent counterscreen for inhibitors of the Janus kinase 2 mutant JAK2V617F: dose response cell-based high throughput screening assay for inhibitors of parental Ba/F3 cell viability. [AID1699, Type: confirmatory]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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8
[SID24836573]
Potency 1.6511Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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9
[SID24836573]
AC50_uM 1.802HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3 [AID493085, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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10
[SID24836573]
irf1 Inhibition [Ba/F3 cells] (IC50) 2.361Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. [AID2165_4, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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11
[SID24836573]
Potency 2.6169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID24836573]
irf1 Inhibition [HEL cells] (IC50) 2.749Late stage results from the probe development effort to identify inhibitors of the Janus kinase 2 mutant JAK2V617F. [AID2165_3, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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13
[SID24836573]
DR_IC50 3.01Confirmatory Screen: Chemical Inhibitors of TNF alpha stimulated E Selectin expression [AID1288, Type: confirmatory]selectin E [Homo sapiens] [gi:56417702]
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14
[SID24836573]
AC50_uM 4.087Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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15
[SID24836573]
EC50 4.838Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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16
[SID24836573]
AC50_uM 4.924ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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17
[SID24836573]
IC50 5.66Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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18
[SID24836573]
IC50 5.66Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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19
[SID24836573]
Potency 6.3096qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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20
[SID24836573]
IC50 7.28Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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21
[SID24836573]
IC50 7.28Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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22
[SID24836573]
IC50 7.536Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID651672, Type: confirmatory]perilipin-1 [Homo sapiens] [gi:223718203]
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23
[SID24836573]
IC50 7.639Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504609, Type: confirmatory]
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24
[SID24836573]
IC50_Mean 8.47Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format [AID504593, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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25
[SID24836573]
IC50_Mean 8.47Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction in luminescent format [AID504593, Type: confirmatory]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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26
[SID24836573]
IC50_Mean 9.78Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay [AID504669, Type: confirmatory]BRCA1-associated RING domain protein 1 [gi:116241265]
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27
[SID24836573]
IC50_Mean 9.78Dose Response confirmation of Inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay [AID504669, Type: confirmatory]Breast cancer type 1 susceptibility protein [gi:728984]
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28
[SID24836573]
AbsAC35_uM 11.09Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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29
[SID24836573]
Potency 11.5821qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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30
[SID24836573]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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31
[SID24836573]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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32
[SID24836573]
Potency 14.1254Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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33
[SID24836573]
AbsAC35_uM 17.28Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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34
[SID24836573]
Max_Activity_Conc_uM 26Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
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35
[SID24836573]
Mean Mutant EC50 888.18E3 Ligase_Mutant_Dose Response [AID1442, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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36
[SID24836573]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
37
[SID24836573]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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38
[SID24836573]
Primary HTS assay for chemical inhibitors of TNF alpha stimulated E-Selectin expression [AID1246, Type: screening]selectin E [Homo sapiens] [gi:56417702]
View
39
[SID24836573]
E3 Ligase HTS_1536 [AID1230, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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40
[SID24836573]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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41
[SID24836573]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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42
[SID24836573]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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43
[SID24836573]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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44
[SID24836573]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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45
[SID24836573]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
View
46
[SID24836573]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]perilipin-5 [Homo sapiens] [gi:116292172]
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47
[SID24836573]
uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assay [AID1012, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
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48
[SID24836573]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format - Set 2 [AID504601, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
49
[SID24836573]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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50
[SID24836573]
Leishmania major promastigote HTS [AID1063, Type: screening]
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