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MLS001183598 (CID 23724291) - Compound BioActivity Data
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BioActivity Outcomes:
Active(48)
 
 
Inactive(490)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
alkPPc(10)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(378)
 
 
 
Confirmatory(169)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(122)
 
 
 
 
 
IC50(33)
 
 
 
EC50(7)
 
 
 
AC50(4)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 514    Data Row: 557   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47202173]
Potency 0.92qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID47202173]
AC50_uM 1.58Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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3
[SID47202173]
IC50_Mean 1.63Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID488785, Type: confirmatory]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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4
[SID47202173]
EC50_Mean 3.19Dose response confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID489024, Type: confirmatory]
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5
[SID47202173]
IC50_Mean 3.36Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase [AID488876, Type: confirmatory]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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6
[SID47202173]
AC50_uM 7.93Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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7
[SID47202173]
Potency 8.1995qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID47202173]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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9
[SID47202173]
AC50_uM 14.06VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity [AID720632, Type: confirmatory]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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10
[SID47202173]
Potency 14.1254qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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11
[SID47202173]
Potency 15.8489qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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12
[SID47202173]
Potency 18.8876qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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13
[SID47202173]
IC50 23.65A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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14
[SID47202173]
Potency 25.1189qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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15
[SID47202173]
Potency 35.4813qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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16
[SID47202173]
Potency 39.8107qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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17
[SID47202173]
CC50 40Vero Cytoxicity Assay: A Cell Based Secondary Assay to Explore Cytotoxicity of Compounds that Inhibit Flavivirus Genomic Capping Enzyme [AID588742, Type: confirmatory]
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18
[SID47202173]
Potency 50.1187qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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19
[SID47202173]
Potency 50.1187qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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20
[SID47202173]
IC50 66.18Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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21
[SID47202173]
IC50_Mean 78Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. [AID488906, Type: confirmatory]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
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22
[SID47202173]
IC50 100Primary and Confirmatory Screening for Flavivirus Genomic Capping Enzyme Inhibition [AID588689, Type: confirmatory]Chain A, Crystal Structure Of Dengue-2 Virus Methyltransferase Complexed With S-Adenosyl-L-Homocysteine [gi:219689243]
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23
[SID47202173]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH; PLA2G7) [AID463230, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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24
[SID47202173]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the plasma platelet activating factor acetylhydrolase (pPAFAH) [AID463082, Type: screening]platelet-activating factor acetylhydrolase precursor [Homo sapiens] [gi:270133071]
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25
[SID47202173]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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26
[SID47202173]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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27
[SID47202173]
QFRET-based biochemical high throughput primary assay to identify inhibitors of human group III secreted phospholipase A2 enzyme (HGIII-sPLA2) [AID743126, Type: screening]phospholipase A2, group III [Homo sapiens] [gi:119580345]
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28
[SID47202173]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
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29
[SID47202173]
Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID540248, Type: other]HTRA1 protein [gi:121945198]
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30
[SID47202173]
Single concentration confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay [AID434971, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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31
[SID47202173]
uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
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32
[SID47202173]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the DAF-12 from the parasite S. stercoralis (ssDAF-12) [AID652126, Type: screening]Protein DAF-12, isoform a [Caenorhabditis elegans] [gi:71987181]
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33
[SID47202173]
Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID743445, Type: screening]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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34
[SID47202173]
VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID686996, Type: screening]Caspase 6, apoptosis-related cysteine peptidase [Homo sapiens] [gi:13325293]
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35
[SID47202173]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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36
[SID47202173]
Fluorescence polarization-based counterscreen for RBBP9 inhibitors: primary biochemical high throughput screening assay to identify inhibitors of the oxidoreductase glutathione S-transferase omega 1(GSTO1). [AID1974, Type: screening]glutathione S-transferase omega-1 isoform 1 [Homo sapiens] [gi:4758484]
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37
[SID47202173]
QFRET-based primary biochemical high throughput screening assay to identify inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase (PFM18AAP). [AID1822, Type: screening]M18 aspartyl aminopeptidase [Plasmodium falciparum 3D7] [gi:23505220]
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38
[SID47202173]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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39
[SID47202173]
Single concentration confirmation of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463112, Type: screening]
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40
[SID47202173]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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41
[SID47202173]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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42
[SID47202173]
Fluorescence-based biochemical primary high throughput screening assay to identify molecules that bind r(CAG) RNA repeats [AID651821, Type: screening]
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43
[SID47202173]
Fluorescence-based biochemical high throughput confirmation assay to identify molecules that bind r(CAG) RNA repeats [AID652065, Type: screening]
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44
[SID47202173]
Counterscreen for molecules that bind rCAG RNA repeats: fluorescent based biochemical counterscreen assay for inhibitors of the DNA-based (5'CAG/3'GTC) TO-PRO-1 dye complex [AID652068, Type: screening]
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45
[SID47202173]
Counterscreen for inhibitors of the HGIII-SPLA2: QFRET-based biochemical high throughput screening assay to identify inhibitors that optically interfere with 535nm fluorescence [AID743282, Type: screening]
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46
[SID47202173]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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47
[SID47202173]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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48
[SID47202173]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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49
[SID47202173]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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50
[SID47202173]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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