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SMR000495779 (CID 23723457) - Compound BioActivity Data
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BioActivity Outcomes:
Active(16)
 
 
Inactive(527)
 
 
Inconclusive(7)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
TRP 2(20)
 
 
 
7TM GPCR Srsx(15)
 
 
CAP ED(5)
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(379)
 
 
 
Confirmatory(166)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(118)
 
 
 
 
 
IC50(28)
 
 
EC50(17)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 551   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47197229]
EC50 0.0267Confirmation dose response assay for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434937, Type: confirmatory]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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2
[SID47197229]
EC50 0.22694Luminescence-based cell-based high throughput dose response assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID588407, Type: confirmatory]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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3
[SID47197229]
EC50 0.22694Luminescence-based cell-based high throughput dose response assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID588407, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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4
[SID134220670]
EC50 0.403Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response assay [AID651685, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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5
[SID134220670]
EC50 0.403Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response assay [AID651685, Type: confirmatory]opioid receptor, delta 1 [Homo sapiens] [gi:119628077]
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6
[SID134220670]
EC50 1.1Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response OPRD1 counterscreen [AID651686, Type: confirmatory]opioid receptor, delta 1 [Homo sapiens] [gi:119628077]
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7
[SID47197229]
Potency 4.1475Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID47197229]
EC50 4.502Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization [AID588411, Type: confirmatory]delta-type opioid receptor [Homo sapiens] [gi:63477962]
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9
[SID47197229]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
View
10
[SID47197229]
Luminescence-based cell-based high throughput confirmation assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504904, Type: screening]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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11
[SID47197229]
Confirmatory screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID2426, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
12
[SID47197229]
Luminescence-based cell-based high throughput confirmation assay for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504904, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
View
13
[SID47197229]
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
14
[SID47197229]
Second confirmatory screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID2461, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
15
[SID47197229]
Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]delta-type opioid receptor [Homo sapiens] [gi:63477962]
View
16
[SID47197229]
Specificity screen against TRPC6 for compounds that activate transient receptor potential cation channel C4 (TRPC4) [AID434950, Type: screening]short transient receptor potential channel 6 isoform 1 [Mus musculus] [gi:160333370]
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17
[SID47197229]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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18
[SID47197229]
Potency 5.6234qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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19
[SID134220670]
CC50 10Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response counterscreen assay to determine cytotoxicity of test compounds [AID651904, Type: confirmatory]
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20
[SID47197229]
Potency 12.5893qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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21
[SID134220670]
EC50 14.9Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response OPRM1 counterscreen [AID651689, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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22
[SID47197229]
EC50 24.291Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRM1 homodimerization [AID588435, Type: confirmatory]mu-type opioid receptor isoform MOR-1 [Homo sapiens] [gi:117940060]
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23
[SID47197229]
Potency 35.4813qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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24
[SID134220670]
EC50 40Late-stage results from the probe development effort to identify activators of OPRM1 and OPRD1 heterodimer formation: luminescence-based cell-based dose response HTR5A counterscreen [AID651688, Type: confirmatory]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
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25
[SID47197229]
EC50 92.507Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput dose response assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID588408, Type: confirmatory]5-hydroxytryptamine receptor 5A [Homo sapiens] [gi:13236497]
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26
[SID47197229]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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27
[SID47197229]
Second counter screen for compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID434977, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
28
[SID47197229]
Second counter screen for compounds that inhibit transient receptor potential cation channel C4 (TRPC4) [AID434978, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
29
[SID47197229]
Second counter screen for compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID434979, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
30
[SID47197229]
Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). [AID2247, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
31
[SID47197229]
Second confirmatory screen for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2554, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
32
[SID47197229]
Confirmatory screen for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2555, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
33
[SID47197229]
Confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4) [AID2636, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
34
[SID47197229]
Second confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4) [AID2637, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
View
35
[SID47197229]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
View
36
[SID47197229]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of the HTRA serine peptidase 1 (HTRA1) [AID504803, Type: screening]HTRA1 protein [gi:121945198]
View
37
[SID47197229]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
View
38
[SID47197229]
Primary cell-based high throughput screening assay to identify inhibitors of kruppel-like factor 5 (KLF5) [AID1700, Type: screening]Kruppel-like factor 5 [Homo sapiens] [gi:124263658]
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39
[SID47197229]
uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase [AID2524, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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40
[SID47197229]
uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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41
[SID47197229]
HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L isoform 2 precursor [Mus musculus] [gi:124486680]
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42
[SID47197229]
uHTS Luminescent assay for identification of activators of mouse intestinal alkaline phosphatase [AID2805, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
View
43
[SID47197229]
uHTS Luminescent assay for identification of inhibitors of mouse intestinal alkaline phosphatase [AID2806, Type: screening]intestinal alkaline phosphatase precursor [Mus musculus] [gi:124487323]
View
44
[SID47197229]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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45
[SID47197229]
Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID504621, Type: screening]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
View
46
[SID47197229]
Fluorescence-based counterscreen assay for HCV NS3 helicase inhibitors: biochemical high-throughput screening assay to identify compounds that cause fluorescent intercalator displacement (FID) [AID1845, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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47
[SID47197229]
Fluorescence-based primary biochemical high throughput screening assay to identify inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1800, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
View
48
[SID47197229]
C. difficile toxins: HTS for inhibitors of TcdB glycohydrolase activity Measured in Biochemical System Using Plate Reader - 7074-01_Inhibitor_SinglePoint_HTS_Activity [AID652162, Type: screening]toxin B [Clostridium difficile 630] [gi:126698238]
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49
[SID47197229]
Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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50
[SID47197229]
RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
View