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1-(2-chloro-6-methyl-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine (CID 23723160) - Compound BioActivity Data
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BioActivity Outcomes:
Active(46)
 
 
Inactive(206)
 
 
Inconclusive(12)
 
 
Unspecified(1)
 
 
Top Targets:
KCNQ channel(13)
 
 
 
7tm 4(11)
 
 
 
TRP 2(9)
 
 
 
RasGEF(4)
 
 
RGS RGS4(4)
 
 
 
BioAssay Types:
Screening(172)
 
 
 
Confirmatory(87)
 
 
 
 
 
BioActivity Types:
Potency(70)
 
 
 
 
 
EC50(8)
 
 
 
IC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 248    Data Row: 265   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47195782]
EC50 3.13Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID47195782]
EC50 6.59A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
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3
[SID47195782]
Potency 11.5821A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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4
[SID47195782]
EC50 11.748Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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5
[SID47195782]
Potency 12.5893qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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6
[SID47195782]
EC50 12.913Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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7
[SID47195782]
Potency 15.8489qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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8
[SID47195782]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID47195782]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID47195782]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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11
[SID47195782]
IC50 32.733A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
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12
[SID47195782]
IC50 71.8A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
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13
[SID47195782]
IC50 78.49A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
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14
[SID47195782]
EC50 115.786Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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15
[SID47195782]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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16
[SID47195782]
MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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17
[SID47195782]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Cancer Stem Cells [AID2717, Type: screening]
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18
[SID47195782]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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19
[SID47195782]
Single concentration confirmation of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID485299, Type: screening]
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20
[SID47195782]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Full-Length Luciferase Counterscreen assay [AID504607, Type: screening]
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