Isoetharine (CID 23702) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(56)
 
 
Inactive(807)
 
 
Inconclusive(33)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(22)
 
 
 
7TM GPCR Srsx(18)
 
 
 
alkPPc(14)
 
 
Tryp SPc(12)
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(569)
 
 
 
 
Confirmatory(273)
 
 
 
 
 
Literature(19)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(202)
 
 
 
 
 
IC50(46)
 
 
 
EC50(17)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 829    Data Row: 898   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID856022]
Potency 0.0065qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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2
[SID856022]
Potency 0.0065qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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3
[SID856022]
Potency 0.0065qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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4
[SID856022]
Potency 0.0065qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation with GloSensor [AID588790, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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5
[SID856022]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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6
[SID856022]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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7
[SID856022]
Potency 1.9953qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapien [gi:32879895]
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8
[SID856022]
Potency 2.0596qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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9
[SID856022]
Potency 2.0596qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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10
[SID856022]
Potency 2.0596qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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11
[SID856022]
Potency 2.0596qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor: Hit Validation [AID588463, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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12
[SID856022]
Potency 2.8117qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-Biphosphate Aldolase In Complex With Phosphoglycolohydrox [gi:122920737]
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13
[SID856022]
Potency 3.1623qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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14
[SID856022]
Potency 3.1623qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
15
[SID856022]
Potency 3.1623qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
View
16
[SID856022]
Potency 3.1623qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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17
[SID56422893]
EC50 3.84Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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18
[SID56422893]
EC50 3.84Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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19
[SID56422893]
EC50 3.84Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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20
[SID56422893]
EC50 3.84Dose response for HTS for Beta-2AR agonists via FAP method from CP1 [AID588763, Type: confirmatory]ADRB2 gene product [Homo sapiens] [gi:4501969]
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21
[SID103771136]
IC50 6.30957Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay [AID524793, Type: Literature]
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22
[SID50106482]
Potency 7.0795qHTS for differential inhibitors of proliferation of Plasmodium falciparum line Dd2 [AID1882, Type: confirmatory]
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23
[SID103771136]
IC50 7.94328Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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24
[SID50106482]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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25
[SID50106482]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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26
[SID103771136]
IC50 10Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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27
[SID103771136]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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28
[SID50106482]
Potency 11.2202qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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29
[SID103771136]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum D10 after 72 hrs by SYBR green assay [AID524792, Type: Literature]
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30
[SID103771136]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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31
[SID103771136]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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32
[SID50106482]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line GB4 [AID1816, Type: confirmatory]
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33
[SID50106482]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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34
[SID50106482]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line D10 [AID1877, Type: confirmatory]
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35
[SID856022]
Potency 12.5893qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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36
[SID856022]
Potency 12.5893qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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37
[SID50106482]
Potency 15.8489qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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38
[SID856022]
EC50 20.671High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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39
[SID856022]
EC50 24.1High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
View
40
[SID856022]
EC50 125.376Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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41
[SID856022]
EC50 125.376Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of Mex-5 Binding to TCR-2 [AID1960, Type: confirmatory]Zinc finger protein mex- [gi:55976631]
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42
[SID856022]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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43
[SID856022]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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44
[SID856022]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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45
[SID856022]
 Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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46
[SID17405232]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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47
[SID17405232]
 Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E receptor 2 (subtype EP2), 53kDa [Homo sapiens] [gi:31881630]
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48
[SID856022]
 Allosteric Modulators of D1 Receptors: Primary Screen [AID641, Type: screening]
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49
[SID856022]
 Allosteric Modulators of D1 Receptors: Confirmation Screen [AID642, Type: other]
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50
[SID856022]
 Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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