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Methylprednisolone Hemisuccinate (CID 23680530) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(45)
 
 
Inconclusive(16)
 
 
Unspecified(8)
 
 
Top Targets:
NR LBD AR(7)
 
 
 
 
NR LBD ER(7)
 
 
 
NR LBD GR(5)
 
 
 
NR LBD TR(3)
 
 
PAS(2)
 
 
BioAssay Types:
Confirmatory(49)
 
 
 
 
Summary(15)
 
 
 
 
Literature(8)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(62)
 
 
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 76    Data Row: 76   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144207076]
Potency-Replicate_1 0.0668qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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2
[SID144207076]
Ratio Potency (uM) 0.0881713qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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3
[SID144207076]
Ratio Potency (uM) 0.106822qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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4
[SID144207076]
Potency-Replicate_1 0.3011qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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5
[SID144207076]
Potency-Replicate_1 10.6822qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway - cell viability counter screen [AID743074, Type: confirmatory]
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6
[SID48416262]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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7
[SID103771064]
Glucocorticoid receptor agonist [AID742932, Type: other]Glucocorticoid receptor [gi:121069]
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8
[SID103771064]
Evaluated for in vivo neuroprotective activity in a mouse head injury model expressed as 1 hr post injury grip scores [AID130086, Type: Literature]
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9
[SID103771064]
Percent increase in KCN lethality (cytotoxic hypoxia) model against male CF-1 mice at a dose 100 mg/kg administered intravenously [AID130844, Type: Literature]
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10
[SID103771064]
Percent increase in KCN lethality (cytotoxic hypoxia) model against male CF-1 mice at a dose 30 mg/kg administered intravenously [AID130845, Type: Literature]
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11
[SID103771064]
Tested in vivo for neuroprotectant activity against mouse head injury(MHI) model. [AID131976, Type: Literature]
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12
[SID103771064]
Lowest effective dose in a mouse head injury model was reported [AID135622, Type: Literature]
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13
[SID103771064]
Lowest effective dosage in Mouse Head Injury Assay. [AID139247, Type: Literature]
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14
[SID103771064]
IC50 Tested in vitro for the inhibition of iron-dependent lipid peroxidation against rat brain homogenates, by malondialdehyde (MDA) formation assay [AID180509, Type: Literature]
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15
[SID103771064]
Ability to inhibit iron-dependent lipid peroxidation in rat brain homogenate using MDA (malondialdehyde) formation assay at 300 uM [AID182836, Type: Literature]
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16
[SID144207076]
Potency-Replicate_1 0.0473qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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17
[SID144207076]
Potency-Replicate_1 0.0473qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
18
[SID144207076]
Potency qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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19
[SID144207076]
Potency-Replicate_1 qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743075, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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20
[SID144207076]
Ratio Potency (uM) qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway: Summary [AID743077, Type: summary]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
View