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sodium 2-(1,3-benzothiazol-2-yl)-5-benzyl-4-methyl-3-oxo-3,5-dihydro-2H-pyrazolo[4,3-c]pyridin-6-olate (CID 23673720) - Compound BioActivity Data
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BioActivity Outcomes:
Active(54)
 
 
Inactive(382)
 
 
Inconclusive(23)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
7TM GPCR Srsx(15)
 
 
G-alpha(8)
 
 
 
Tryp SPc(8)
 
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(240)
 
 
 
 
Confirmatory(207)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(136)
 
 
 
 
 
IC50(49)
 
 
 
EC50(7)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 411    Data Row: 460   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87544848]
IC50 1.51A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against CXCR4-tropic HIV-1 (HIV-1 PBMC Assay) - Dose Response (3) [AID504625, Type: confirmatory]
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2
[SID87544848]
IC50 1.57A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against CCR5-tropic HIV-1 (HIV-1 PBMC Assay) - Dose Response (3) [AID504626, Type: confirmatory]
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3
[SID87544848]
IC50 2.42A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against CCR5-tropic HIV-1 (HIV-1 PBMC Assay) - Dose Response (2) [AID504560, Type: confirmatory]
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4
[SID26725910]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID26725910]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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6
[SID26725910]
IC50 3.01Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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7
[SID26725910]
IC50 3.01Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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8
[SID87544848]
IC50 3.21A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against CXCR4-tropic HIV-1 (HIV-1 PBMC Assay) - Dose Response (2) [AID504563, Type: confirmatory]
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9
[SID87544848]
IC50 (2% Serum) 3.94A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CCR5-Tropic HIV-1 Fusion Inhibition Assay) - Dose Response (2) [AID504551, Type: confirmatory]
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10
[SID26725910]
IC50 4.3226Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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11
[SID87544848]
TC50 (5% Serum) 5.4A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CCR5-Tropic HIV-1 Fusion Inhibition Assay) - Secondary Cytotoxicity Screen (2) [AID504573, Type: confirmatory]
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12
[SID26725910]
Potency 6.3096Ub-rhodamine 110 based assay for inhibitors Ubiquitin-specific Protease USP2a [AID493170, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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13
[SID87544848]
IC50 6.58SAR analysis of compounds that inhibit Human Immunodeficiency Virus Fusion, cell-cell fusion assay [AID435029, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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14
[SID26725910]
Potency 6.7456qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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15
[SID87544848]
TC50 (2% Serum) 8.94A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CXCR4-Tropic HIV-1 Fusion Inhibition Assay) - Secondary Cytotoxicity Screen (2) [AID504574, Type: confirmatory]
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16
[SID87544848]
IC50 (2% Serum) 9.28A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CCR5-Tropic HIV-1 MAGI Antiviral Assay) - Secondary Assay (4) [AID504553, Type: confirmatory]
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17
[SID87544848]
IC50_Mean 10.1SAR analysis of compounds that inhibit Human Immunodeficiency Virus Fusion. [AID434967, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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18
[SID26725910]
Potency 11.2202CHOP2 Reporter Counterscreen Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID493169, Type: confirmatory]enteropeptidase precursor [Homo sapiens] [gi:223942069]
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19
[SID87544848]
IC50 (5% Serum) 12.5A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CCR5-Tropic HIV-1 MAGI Antiviral Assay) - Secondary Assay [AID2644, Type: confirmatory]
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20
[SID87544848]
TC50 13.2A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (HIV-1 PBMC Assay) - Cytotoxicity Counter Screen - Dose Response (3) [AID504630, Type: confirmatory]
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21
[SID26725910]
IC50 13.8uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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22
[SID87544848]
IC50 (2% Serum) 14.5A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CXCR4-Tropic HIV-1 MAGI Antiviral Assay) - Dose Response (2) [AID504570, Type: confirmatory]
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23
[SID26725910]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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24
[SID26725910]
Potency 15.8489qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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25
[SID26725910]
Potency 15.8489qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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26
[SID26725910]
IC50 17.44A Cell Based Assay for the Identification of Lead Compounds with Inhibitory Activity against HIV-1 Fusion (CCR5 Tropic HIV-1 Fusion Inhibition Assay) - Dose Response [AID2279, Type: confirmatory]
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27
[SID26725910]
AC50_uM 20.47Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity [AID624273, Type: confirmatory]FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) [Mycobacterium tuberculosis H37Rv] [gi:1781172]
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28
[SID26725910]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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29
[SID87544848]
TC50 21A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (HIV-1 PBMC Assay) - Cytotoxicity Counter Screen - Dose Response (2) [AID504571, Type: confirmatory]
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30
[SID26725910]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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31
[SID87544848]
IC50 (2% Serum) 27.4A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CXCR4-Tropic HIV-1 Fusion Inhibition Assay) - Dose Response (2) [AID504561, Type: confirmatory]
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32
[SID26725910]
Magi EC50 33.22A Cell Based Assay for the Identification of Lead Compounds with Inhibitory Activity against HIV-1 Fusion (CCR5 Tropic HIV-1 Fusion Inhibition Assay) - Cytotoxicity Counter Screen - Dose Response [AID2286, Type: confirmatory]
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33
[SID26725910]
Potency 35.4813qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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34
[SID26725910]
Potency 39.8107qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
View
35
[SID26725910]
Potency 44.6684qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
View
36
[SID26725910]
Potency 44.6684Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2708, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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37
[SID87544848]
TC50 (2% Serum) 100A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CXCR4-Tropic HIV-1 MAGI Antiviral Assay) - Secondary Cytotoxicity Screen (2) [AID504575, Type: confirmatory]
View
38
[SID87544848]
TC50 (2% Serum) 100A Cell Based Assay for the Characterization of Lead Compounds with Antiviral Activity against HIV-1 (CCR5-Tropic HIV-1 MAGI Antiviral Assay) - Secondary Cytotoxicity Screen (4) [AID504576, Type: confirmatory]
View
39
[SID26725910]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
View
40
[SID26725910]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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41
[SID26725910]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-activating enzyme E1 regulatory subunit isoform a [Homo sapiens] [gi:4502169]
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42
[SID26725910]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (eIF4H) [AID2012, Type: confirmatory]Eukaryotic translation initiation factor 4H [Homo sapiens] [gi:45219878]
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43
[SID26725910]
IC50 uHTS fluorescence polarization assay for the identification of translation initiation inhibitors (PABP) [AID2014, Type: confirmatory]polyadenylate-binding protein 1 [Homo sapiens] [gi:46367787]
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44
[SID26725910]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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45
[SID26725910]
uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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46
[SID26725910]
Potency qHTS for Inhibitors of phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) [AID652105, Type: confirmatory]Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [gi:18266879]
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47
[SID26725910]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-conjugating enzyme Ubc12 [Homo sapiens] [gi:4507791]
View
48
[SID26725910]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
View
49
[SID26725910]
uHTS for Small Molecule Inhibitors of Eukaryotic Translation Initiation [AID782, Type: screening]eukaryotic translation initiation factor 4 gamma 1 isoform 4 [Homo sapiens] [gi:302699239]
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50
[SID26725910]
Fluorescence-based confirmation biochemical high throughput screening assay for inhibitors of the Hepatitis C Virus non-structural protein 3 helicase (NS3) [AID1943, Type: screening]NS3 [Hepatitis C virus] [gi:125541954]
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