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amfenac (CID 23665728) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(120)
 
 
Inconclusive(8)
 
 
Unspecified(22)
 
 
Top Targets:
NR LBD AR(14)
 
 
 
NR LBD ER(14)
 
 
 
NR LBD GR(8)
 
 
NR LBD TR(6)
 
 
PAS(4)
 
 
BioAssay Types:
Confirmatory(98)
 
 
 
 
Summary(30)
 
 
 
 
Literature(25)
 
 
 
Screening(4)
 
 
 
BioActivity Types:
Potency(124)
 
 
 
 
IC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 91    Data Row: 157   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103201400]
IC50 0.1Inhibitory activity against Prostaglandin G/H synthase [AID161308, Type: Literature]
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2
[SID103201400]
IC50 0.2Inhibition of prostaglandin G/H synthase obtained from bovine seminal vesicles. [AID160707, Type: Literature]
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3
[SID103201400]
IC50 0.2Evaluated for the inhibition of prostaglandin synthetase obtained from bovine seminal vesicles at the dose of 4.0 mg/kg (p.o.) [AID160886, Type: Literature]
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4
[SID144206568]
Potency-Replicate_1 10.5909qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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5
[SID144206568]
Ratio Potency (uM) 22.1476qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743140, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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6
[SID144206567]
qHTS of D3 Dopamine Receptor Agonist: qHTS [AID652048, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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7
[SID144206567]
qHTS of D3 Dopamine Receptor Potentiators: qHTS [AID652051, Type: screening]D(3) dopamine receptor isoform e [Homo sapiens] [gi:89191863]
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8
[SID103201400]
Oral analgesic activity was determined in mice by the acetylcholine-induced abdominal constriction assay upon ip administration of acetylcholine bromide 20 min following oral administration [AID114054, Type: Literature]
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9
[SID103201400]
Oral analgesic activity was determined in mice by the acetylcholine-induced abdominal constriction assay upon ip administration of acetylcholine bromide 5 hours following oral administration [AID114055, Type: Literature]
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10
[SID103201400]
Percent change of the antiinflammatory activity in the 5-h Evans Blue-Carrageenan induced pleural effusion assay at the dose of 0.8 mg/kg (p.o.) [AID170704, Type: Literature]
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11
[SID103201400]
Percent change of the antiinflammatory activity in the 5-h Evans Blue-Carrageenan induced pleural effusion assay at the dose of 4.0 mg/kg (p.o.) [AID170707, Type: Literature]
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12
[SID103201400]
Antiinflammatory activity was tested in Pleural effusion rate assay and the percent change in average volume of pleural fluid at indomethacin dose of 4.0 mg/kg. [AID171870, Type: Literature]
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13
[SID103201400]
Antiinflammatory activity was tested in Pleural effusion rate assay and the percent change in average volume of pleural fluid at the dose of 100 mg/kg [AID171871, Type: Literature]
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14
[SID103201400]
Antiinflammatory activity was tested in pleural effusion rate assay and the percent change in average volume of pleural fluid at the dose of 4.0 mg/kg [AID171873, Type: Literature]
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15
[SID103201400]
Percent activity in the 5-h Evans Blue-Carrageenan induced pleural effusion assay at the dose of 0.16 mg/kg (p.o.) [AID172732, Type: Literature]
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16
[SID103201400]
Percent change in average volume of pleural fluid at a dose 4 mg/kg of indomethacin and 5-h response is evaluated by Evans blue-carrageenan induced pleural effusion assay [AID172888, Type: Literature]
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17
[SID103201400]
Percent change in avg. volume of pleural fluid at a dose of 0.16 mg/kg and 5-h response is evaluated by Evans blue-carrageenan induced pleural effusion assay [AID172889, Type: Literature]
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18
[SID103201400]
Percent change in average volume of pleural fluid at a dose of 100 mg/kg and 5-h response by Evans blue-carrageenan induced pleural effusion assay. [AID172890, Type: Literature]
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19
[SID103201400]
Percent change in average volume of pleural fluid at a dose of 4.0 mg/kg and 5-h response by Evans blue-carrageenan induced pleural effusion assay. [AID172892, Type: Literature]
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20
[SID103201400]
Acute gastric toxicity (single oral dose) in male fasted rats [AID179690, Type: Literature]
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