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BioActivity Data for Compound cerivastatin (CID 23663992)

BioActivity Outcomes:
Active(39)
 
 
Inactive(206)
 
 
Inconclusive(38)
 
 
Unspecified(3)
 
 
Top Targets:
NR LBD PPAR(8)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD AR(7)
 
 
 
 
TRP 2(5)
 
 
NR LBD VDR(4)
 
 
 
BioAssay Types:
Confirmatory(124)
 
 
 
 
Screening(123)
 
 
 
Summary(30)
 
 
 
 
Literature(3)
 
 
BioAssay Categories:
Biochemical(29)
 
 
Toxicity(6)
 
 
 
ADME(3)
 
 
Cell-based(77)
 
 
 
 
Organism-base..(5)
 
 
 
BioActivity Types:
Potency(107)
 
 
 
 
IC50(26)
 
 
 
EC50(7)
 
 
 
 
AC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 273    Data Row: 286   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID170465109]
Potency-Replicate_1 0.006qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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2
[SID144205797]
Potency-Replicate_1 0.0133qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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3
[SID251919809]
Potency-Replicate_1 0.027qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID1159521, Type: confirmatory]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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4
[SID170465109]
Antagonist Potency (uM) 0.0298493qHTS assay to identify small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway: Summary [AID1159523, Type: summary]RAR-related orphan receptor gamma [Mus musculus] [gi:15928672]
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5
[SID170465109]
IC50 0.05291GSK3B-pretreated HCT116 viability from Cell TiterGlo-IC50 [AID1117339, Type: confirmatory]
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6
[SID144205797]
Potency-Replicate_1 0.075qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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7
[SID170465109]
IC50 0.0894VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area decrease-IC50 [AID1117337, Type: confirmatory]
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8
[SID49681715]
EC50_uM 0.104Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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9
[SID170465109]
IC50 0.14328SW480 viability from Cell TiterGlo-IC50 [AID1117338, Type: confirmatory]
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10
[SID144205797]
Ratio Potency (uM) 0.197391qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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11
[SID170465109]
IC50 0.24031HCT116 viability from Cell TiterGlo-IC50 [AID1117332, Type: confirmatory]
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12
[SID170465109]
IC50 0.259VEGF stimulated ADSC/ECFC co-culture nuclear area decrease (viability)-IC50 [AID1117324, Type: confirmatory]
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13
[SID144205797]
Potency-Replicate_1 0.2985qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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14
[SID144205797]
Potency 0.5957qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID170465109]
IC50 1.01305RKO viability from Cell TiterGlo-IC50 [AID1117322, Type: confirmatory]
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16
[SID144205797]
Potency 1.1886qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID170465109]
IC50 1.21161HT-29 viability from Cell TiterGlo-IC50 [AID1117330, Type: confirmatory]
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18
[SID170465109]
IC50 1.8733SNU-C1 viability from Cell TiterGlo-IC50 [AID1117323, Type: confirmatory]
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19
[SID170465109]
IC50 1.92447Colo320 viability from Cell TiterGlo-IC50 [AID1117334, Type: confirmatory]
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20
[SID170465109]
IC50 2.50651DLD-1 viability from Cell TiterGlo-IC50 [AID1117352, Type: confirmatory]
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