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fluvastatin (CID 23663976) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(44)
 
 
Inactive(582)
 
 
Inconclusive(35)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(17)
 
 
NR LBD PPAR(8)
 
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
BioAssay Types:
Screening(384)
 
 
 
 
Confirmatory(224)
 
 
 
 
 
Literature(27)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(201)
 
 
 
 
 
IC50(38)
 
 
 
EC50(6)
 
 
AC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 613    Data Row: 668   Total Pages: 34   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103351132]
IC50 0.0025Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040 [AID80972, Type: Literature]
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2
[SID103351132]
IC50 0.0025In vitro inhibition of solubilized HMG-CoA reductase in rat liver. [AID83479, Type: Literature]
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3
[SID103351132]
IC50 0.004Incorporation of [14C]- acetate into sterols measured in rat testis. [AID179217, Type: Literature]
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4
[SID144205779]
Potency-Replicate_1 0.0094qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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5
[SID103351132]
IC50 0.032Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver. [AID83469, Type: Literature]
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6
[SID103351132]
IC50 0.079Tested for ability to inhibit incorporation of [14C]acetate into cholesterol in cultured human hepatoma (HEP-G2) cells; 0.053-0.12 [AID81400, Type: Literature]
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7
[SID103351132]
IC50 0.142Incorporation of [14C]- acetate into sterols measured in rat liver. [AID179215, Type: Literature]
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8
[SID103351132]
IC50 0.292Incorporation of [14C]- acetate into sterols measured in rat spleen. [AID179216, Type: Literature]
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9
[SID49666153]
IC50 0.53244Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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10
[SID144205779]
Potency-Replicate_1 1.0591qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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11
[SID49666153]
IC50 1.219Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID624395, Type: confirmatory]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
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12
[SID49666153]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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13
[SID49666153]
Potency 1.4581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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14
[SID49666153]
AC50_uM 2.4Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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15
[SID144205779]
Potency-Replicate_1 3.3491qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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16
[SID144205779]
Potency 5.9569qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID144205779]
Potency 6.6838qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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18
[SID49666153]
Potency 9.2qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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19
[SID144205779]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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20
[SID49666153]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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