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BioActivity Data for Compound MLS002608114 (CID 236330)

BioActivity Outcomes:
Active(6)
 
 
Inactive(309)
 
 
Inconclusive(3)
 
 
Unspecified(10)
 
 
Top Targets:
7tm 4(23)
 
 
ZnMc TACE lik..(8)
 
 
 
ABCC CFTR1(4)
 
 
Troponin(4)
 
 
CAP ED(4)
 
 
BioAssay Types:
Screening(220)
 
 
 
Confirmatory(94)
 
 
 
 
 
Literature(9)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(97)
 
 
 
 
Toxicity(4)
 
 
Cell-based(72)
 
 
Organism-base..(8)
 
 
BioActivity Types:
Potency(73)
 
 
 
 
IC50(20)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 281    Data Row: 328   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID87335474]
IC50 3.672QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 [AID743260, Type: confirmatory]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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2
[SID172232648]
IC50 3.756Late stage QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM17 [AID743337, Type: confirmatory]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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3
[SID87335474]
QFRET-based biochemical primary high throughput screening assay to identify exosite inhibitors of ADAM17. [AID720648, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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4
[SID87335474]
QFRET-based biochemical high throughput confirmation assay to identify exosite inhibitors of ADAM17 [AID743257, Type: screening]disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] [gi:73747889]
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5
[SID172232648]
Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473, Type: confirmatory]
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6
[SID87335474]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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7
[SID172232648]
IC50 {MMP8} 6.4Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_3, Type: confirmatory]matrix metallopeptidase 8 (neutrophil collagenase) [Homo sapiens] [gi:119587431]
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8
[SID172232648]
IC50 {MMP1} 18.5Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_1, Type: confirmatory]matrix metallopeptidase 1 (interstitial collagenase) [Homo sapiens] [gi:119587435]
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9
[SID172232648]
IC50 {MMP9} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_4, Type: confirmatory]matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) [Homo sapiens] [gi:119596182]
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10
[SID172232648]
IC50 {MMP10} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_5, Type: confirmatory]matrix metallopeptidase 10 (stromelysin 2) [Homo sapiens] [gi:119587433]
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11
[SID172232648]
IC50 {Meprin A} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_8, Type: confirmatory]MEP1A protein [Homo sapiens] [gi:219520038]
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12
[SID172232648]
IC50 {MMP14} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_7, Type: confirmatory]matrix metalloproteinase 14 (membrane-inserted) [Homo sapiens] [gi:408684256]
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13
[SID172232648]
IC50 {MMP2} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_2, Type: confirmatory]matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) [Homo sapiens] [gi:51831776]
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14
[SID172232648]
IC50 {MMP13} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_6, Type: confirmatory]matrix metalloproteinase 13 (collagenase 3) [Homo sapiens] [gi:51895762]
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15
[SID172232648]
IC50 {Meprin B} 100Late stage assay provider QFRET-based biochemical high throughput dose response assay to counterscreen inhibitors of ADAM10 and ADAM17 against metalloproteases MMP1, MMP2, MMP8, MMP9, MMP10, MMP13, MMP14, Meprin A, and Meprin B [AID743473_9, Type: confirmatory]Meprin A, beta [Homo sapiens] [gi:223460866]
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16
[SID87335474]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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17
[SID87335474]
IC50 29.359Counterscreen for exosite inhibitors of ADAM17: Fluorescence resonance energy transfer (FRET)-based biochemical high throughput dose response assay to identify inhibitors of ADAM10 [AID743259, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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18
[SID172232648]
IC50 32.32Late stage QFRET-based biochemical high throughput dose response assay to identify exosite inhibitors of ADAM10. [AID743338, Type: confirmatory]ADAM10 [Homo sapiens] [gi:2393947]
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19
[SID87335474]
Potency 58.4789qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1, partial [Homo sapiens] [gi:89573979]
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20
[SID87335474]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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