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beta-Naphthoflavone (CID 2361) - Compound BioActivity Data
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BioActivity Outcomes:
Active(75)
 
 
Inactive(252)
 
 
Inconclusive(36)
 
 
Unspecified(194)
 
 
Top Targets:
7TM GPCR Srsx(27)
 
 
 
 
7TM GPCR Srx(26)
 
 
 
p450(17)
 
 
 
Death TRAILR..(12)
 
 
 
 
Neur chan LBD(11)
 
 
BioAssay Types:
Screening(187)
 
 
 
 
Confirmatory(124)
 
 
 
 
Literature(79)
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
IC50(124)
 
 
 
 
Potency(123)
 
 
 
 
AC50(9)
 
 
 
 
Ki(4)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 519    Data Row: 557   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103198693]
Ki 0.026Compound was evaluated for inhibition constant, in liver microsomes from 3-methylcholanthrene-exposed rats [AID6989, Type: Literature]
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2
[SID103198693]
IC50 0.054Inhibition of CYP1A1 (unknown origin)-mediated deethylation of resorufin ethyl ether after 5 mins by spectrofluorimetric analysis [AID739410, Type: Literature]Cytochrome P450 1A1 [gi:117139]
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3
[SID144212341]
ATAD5 Potency (uM) 0.0611306qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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4
[SID144212341]
Potency-Replicate_1 0.077qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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5
[SID103198693]
Ki 0.13Compound was evaluated for inhibition constant, in liver microsomes from beta-naphthoflavone-exposed rats [AID6990, Type: Literature]
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6
[SID99356175]
AC50_uM 0.26PAX8: PAX8-dependent cytoxicity Measured in Cell-Based System Using Plate Reader - 7054-06_Inhibitor_Dose_CherryPick_Activity [AID687029, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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7
[SID99356175]
AC50_uM 0.26SA5-Pax8: Cytotoxicity IOSE-T80 Measured in Cell-Based System Using Plate Reader - 7054-07_Inhibitor_Dose_CherryPick_Activity [AID687032, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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8
[SID103198693]
IC50 0.47Inhibition of CYP1A2 (unknown origin)-mediated demethylation of resorufin methyl ether after 5 mins by spectrofluorimetric analysis [AID739409, Type: Literature]Cytochrome P450 1A2 [gi:117144]
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9
[SID99356175]
AC50_uM 0.646Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity [AID588343, Type: confirmatory]
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10
[SID144212341]
Ratio Potency (uM) 0.830982qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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11
[SID103198693]
EC50 1.4Agonist activity at AhR in human MCF-7 cells assessed as increase of CYP1A1-dependent 7-ethoxyresorufin O-deethylase activity [AID600453, Type: Literature]Aryl hydrocarbon receptor [gi:3041653]
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12
[SID103198693]
EC50 1.4Agonist activity at aryl hydrocarbon receptor in human MCF7 cells after 24 hrs CYP1A1-dependent EROD assay [AID458180, Type: Literature]Aryl hydrocarbon receptor [gi:3041653]
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13
[SID99356175]
AbsAC35_uM 1.43Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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14
[SID103198693]
Ki 1.48In vitro affinity against Benzodiazepine receptor binding to rat cortical membranes (using [3H]- flumazenil as radioligand). [AID40670, Type: Literature]
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15
[SID99356175]
AbsAC35_uM 1.57HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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16
[SID144212341]
Potency-Replicate_1 2.4337qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line [AID743079, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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17
[SID103198693]
IC50 2.5149DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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18
[SID144212341]
Potency-Replicate_1 4.8558qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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19
[SID103198693]
IC50 5.4667DRUGMATRIX: Protein Serine/Threonine Kinase, ERK1 enzyme inhibition (substrate: Myelin Basic Protein) [AID625180, Type: other]Mitogen-activated protein kinase 3 [gi:232066]
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20
[SID144212341]
AhR Potency (uM) 5.66142qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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21
[SID99356175]
AbsAC35_uM 5.83Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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22
[SID99356175]
AC50_uM 5.9HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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23
[SID144212341]
TR Potency (uM) 7.40614qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway: Summary [AID743067, Type: summary]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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24
[SID103198693]
EC50 8Induction of ARE in human HepG2 cells by luciferase assay [AID380495, Type: Literature]
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25
[SID99356175]
AC50_uM 8.533Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504882, Type: confirmatory]LMP1 [Human herpesvirus 4] [gi:23893668]
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26
[SID144212341]
Potency-Replicate_1 8.6349qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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27
[SID144212341]
Potency-Replicate_1 8.7076qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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28
[SID103198693]
Ki 8.8Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes. [AID32357, Type: Literature]
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29
[SID144212341]
Potency-Replicate_1 9.6885qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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30
[SID144212341]
Potency-Replicate_1 13.6854qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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31
[SID144212341]
Potency-Replicate_1 13.8006qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743213, Type: confirmatory]
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32
[SID144212341]
Potency-Replicate_1 15.3553qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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33
[SID144212341]
Potency-Replicate_1 17.3739qHTS assay to identify small molecule agonists of the peroxisome proliferator-activated receptor delta (PPARd) signaling pathway - cell viability counter screen [AID743211, Type: confirmatory]
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34
[SID103198693]
Km 19.2Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at concentration of 25 uM [AID7305, Type: Literature]
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35
[SID144212341]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743221, Type: confirmatory]
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36
[SID144212341]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule agonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743224, Type: confirmatory]
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37
[SID144212341]
Potency-Replicate_1 19.4938qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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38
[SID144212341]
Potency-Replicate_1 21.8724qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway - cell viability counter screen [AID743033, Type: confirmatory]
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39
[SID144212341]
Potency-Replicate_1 24.3365qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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40
[SID144212341]
Potency-Replicate_1 24.5412qHTS assay for small molecule activators of the heat shock response signaling pathway - cell viability counter screen [AID743209, Type: confirmatory]
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41
[SID99356175]
Max_Activity_Conc_uM 26Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent TC71 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-04_Inhibitor_Dose_CherryPick_Activity [AID720570, Type: confirmatory]
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42
[SID103198693]
Km 26.6Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at concentration of 50 uM [AID7306, Type: Literature]
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43
[SID99356175]
AC50_uM 29.22PAX8: non-specific cytotoxicity Measured in Cell-Based System Using Plate Reader - 7054-05_Inhibitor_Dose_DryPowder_Activity [AID743021, Type: confirmatory]
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44
[SID103198693]
Km 33.9Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to beta-naphthoflavone at 500 uM [AID6987, Type: Literature]
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45
[SID103198693]
Km 39.7Michaelis menton constant for 7-ethoxycoumarin deethylation in rat liver microsomes exposed to 3-methylcholanthrene at concentration of 75 uM [AID6973, Type: Literature]
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46
[SID103198693]
Compound was evaluated for alpha -rate constant, in liver microsomes from 3-methylcholanthrene-exposed rats [AID7021, Type: Literature]
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47
[SID103198693]
Compound was evaluated for alpha -rate constant, in liver microsomes from beta-naphthoflavone-exposed rats [AID7022, Type: Literature]
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48
[SID103198693]
Compound tested for its binding to human Orphan receptor (AhR); Active [AID39092, Type: Literature]
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49
[SID103198693]
In vitro inhibitory activity against the growth of WISH cell derived from human cervical carcinoma was determined; slight effect [AID216252, Type: Literature]
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50
[SID103198693]
Induction of quinone reductase activity in mouse Hepa 1c1c7 cells assessed as concentration required to double the enzyme activity [AID294478, Type: Literature]
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