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3-Cl-AHPC analogue, 10 (CID 23577110) - Compound BioActivity Data
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BioActivity Outcomes:
Active(4)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD SHP(2)
 
 
 
PTPc(1)
 
 
BioAssay Types:
Literature(15)
 
 
 
BioActivity Types:
IC50(7)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 15    Data Row: 15   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103606095]
IC50 0.5Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP by liquid scintillation counting relative to 3-Cl-AHPC [AID364173, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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2
[SID103606095]
IC50 2.27Inhibition of SHP2 overexpressed in human KG1 cells [AID364175, Type: Literature]Tyrosine-protein phosphatase non-receptor type 11 [gi:84028248]
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3
[SID103606095]
IC50 3.6Antiproliferative activity against human H292 cells after 72 hrs by MTT assay [AID365048, Type: Literature]
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4
[SID103606095]
IC50 13.5Induction of apoptosis in human KG1 cells after 48 hrs by acridine orange staining [AID365043, Type: Literature]
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5
[SID103606095]
IC50 5Antiproliferative activity against human KG1 AML cells after 48 hrs by MTT assay [AID365045, Type: Literature]
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6
[SID103606095]
IC50 5Antiproliferative activity against human DU145 cells after 72 hrs by MTT assay [AID365046, Type: Literature]
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7
[SID103606095]
IC50 5Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay [AID365047, Type: Literature]
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8
[SID103606095]
Induction of apoptosis in human KG1 cells at 25 uM after 48 hrs by acridine orange staining [AID365044, Type: Literature]
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9
[SID103606095]
Induction of apoptosis in human KG1 cells at 1.0 uM after 48 hrs by acridine orange staining [AID365041, Type: Literature]
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10
[SID103606095]
Induction of apoptosis in human KG1 cells at 5.0 uM after 48 hrs by acridine orange staining [AID365042, Type: Literature]
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11
[SID103606095]
Antiproliferative activity against human KG1 AML cells at 5 uM after 48 hrs by MTT assay [AID365049, Type: Literature]
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12
[SID103606095]
Antiproliferative activity against human DU145 cells at 5 uM after 72 hrs by MTT assay [AID365050, Type: Literature]
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13
[SID103606095]
Antiproliferative activity against human MDA-MB-231 cells at 5 uM after 72 hrs by MTT assay [AID365055, Type: Literature]
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14
[SID103606095]
Antiproliferative activity against human H292 cells at 5 uM after 72 hrs by MTT assay [AID365060, Type: Literature]
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15
[SID103606095]
Displacement of [5,5'-3H2]AHPN from human recombinant GST-SHP at 50 uM by liquid scintillation counting relative to 3-Cl-AHPC [AID364174, Type: Literature]Nuclear receptor subfamily 0 group B member 2 [gi:9978744]
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