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REGID_FOR_CID_2347892 (CID 2347892) - Compound BioActivity Data
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BioActivity Outcomes:
Active(135)
 
 
Inactive(685)
 
 
Inconclusive(25)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(29)
 
 
 
7TM GPCR Srsx(19)
 
 
alkPPc(16)
 
 
Firefly Luc l..(12)
 
 
 
Bcl-2 like(12)
 
 
BioAssay Types:
Screening(525)
 
 
 
 
Confirmatory(291)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(179)
 
 
 
 
 
IC50(60)
 
 
 
EC50(21)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 780    Data Row: 846   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID3714169]
Potency 0.0146FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate and 500microM CoASH [AID602358, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID3714169]
Potency 0.0231FLuc inhibitory activity for the follow-up compounds in a biochemical assay with Km concentrations of substrate [AID602357, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID3714169]
Potency 0.0239qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID3714169]
Potency 0.0326FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM ATP [AID602364, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID3714169]
Potency 0.0447VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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6
[SID3714169]
Potency 0.0501qHTS Assay for Inhibitors of Firefly Luciferase [AID411, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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7
[SID3714169]
Potency 0.0711FLuc inhibitory activity for the follow-up compounds in a biochemical assay with a commercial detection reagent - BriteliteTM Plus (PerkinElmer) [AID602474, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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8
[SID3714169]
Potency 0.0798FLuc inhibitory activity for the follow-up compounds in a cell-based translational read-through assay (72 hour incubation) [AID602478, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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9
[SID3714169]
Potency 0.1005FLuc inhibitory activity for the follow-up compounds in a cell-based assay to assess the activity of miR-21 [AID602477, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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10
[SID3714169]
Potency 0.1554FLuc inhibitory activity for the follow-up compounds in a biochemical assay with an in-house formulation of detection reagent [AID602475, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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11
[SID3714169]
Potency 0.1634FLuc inhibitory activity for the follow-up compounds in a biochemical assay with 1mM D-luciferin [AID602365, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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12
[SID3714169]
Potency 0.1853Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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13
[SID3714169]
IC50_Mean 0.198Dose response confirmation of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489034, Type: confirmatory]
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14
[SID3714169]
Potency 0.2079Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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15
[SID3714169]
IC50_Mean 0.23Dose response confirmation of uHTS of chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489004, Type: confirmatory]
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16
[SID3714169]
IC50_Mean 0.24Dose response counterscreen of uHTS chemical inhibitors of both B-cell and T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489020, Type: confirmatory]
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17
[SID3714169]
EC50 0.311Luminescence Biochemical Dose Response HTS to Identify Inhibitors of Luciferase [AID1891, Type: confirmatory]
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18
[SID3714169]
Potency 0.3162qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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19
[SID3714169]
EC50 0.352Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
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20
[SID3714169]
Potency 0.3981qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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21
[SID3714169]
Potency 0.8913qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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22
[SID3714169]
Potency 1.2589qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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23
[SID3714169]
EC50 1.711Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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24
[SID3714169]
EC50 1.757Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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25
[SID3714169]
Potency 1.8356qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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26
[SID3714169]
Potency 2.0596qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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27
[SID3714169]
EC50 2.178Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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28
[SID3714169]
Potency 2.2387Counterscreen for Luciferase (Kinase-Glo TM) Inhibition [AID1379, Type: confirmatory]luciferase [Photuris pennsylvanica] [gi:1669525]
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29
[SID3714169]
Potency 2.3109Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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30
[SID3714169]
IC50 2.691Homogeneous Time Resolved Fluorescence (HTRF)-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID504701, Type: confirmatory]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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31
[SID3714169]
Potency 5.6234qHTS Assay for Inhibitors of the HIV-1 protein Vpr [AID651644, Type: confirmatory]Vpr [Human immunodeficiency virus 1] [gi:28872817]
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32
[SID3714169]
EC50 6.254Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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33
[SID3714169]
Potency 6.5131qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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34
[SID3714169]
Potency 7.3078qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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35
[SID3714169]
EC50_uM 11.02Luminescence Cell-Free Homogenous Dose Retest to Identify Inhibitors of Serine/Threonine Kinase 33 Activity [AID2821, Type: confirmatory]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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36
[SID3714169]
Potency 15.8489qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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37
[SID3714169]
Potency 15.8489qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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38
[SID3714169]
AC50_uM 16.13Luminescence Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of GSK-3 alpha [AID463203, Type: confirmatory]glycogen synthase kinase-3 alpha [Homo sapiens] [gi:49574532]
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39
[SID3714169]
AC50_uM 24.31Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo [AID463205, Type: confirmatory]
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40
[SID3714169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921310]
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41
[SID3714169]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain B, The Structure Of Wild-Type Human Hadh2 (17beta-Hydroxysteroid Dehydrogenase Type 10) Bound To Nad+ At 1.2 A [gi:122921311]
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42
[SID3714169]
Potency 28.1838qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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43
[SID3714169]
Potency 28.1838qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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44
[SID3714169]
MLPCN Streptokinase Expression Inhibition [AID1662, Type: screening]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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45
[SID173334058]
Confirmed inhibitors of Serine Threonine Kinase 33, STK33 [AID743321, Type: other]serine/threonine-protein kinase 33 isoform a [Homo sapiens] [gi:23943882]
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46
[SID3714169]
Primary Cell-based High Throughput Screening assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID525, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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47
[SID3714169]
Dose-response cell-based assay for inhibitors of the nuclear receptor Steroidogenic Factor 1 (SF-1) [AID600, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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48
[SID3714169]
Counterscreen for inhibitors of the Retinoic Acid Receptor-related orphan receptor A (RORA): A cell-based dose-response assay for inhibition of the Steroidogenic Factor 1 (SF-1) [AID611, Type: confirmatory]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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49
[SID3714169]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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50
[SID3714169]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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