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benzyl benzoate (CID 2345) - Compound BioActivity Data
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BioActivity Outcomes:
Active(5)
 
 
Inactive(873)
 
 
Inconclusive(63)
 
 
Unspecified(33)
 
 
Top Targets:
NR LBD PPAR(29)
 
 
 
NR LBD ER(23)
 
 
NR LBD AR(23)
 
 
 
NR LBD VDR(17)
 
 
 
NR LBD TR(15)
 
 
BioAssay Types:
Confirmatory(408)
 
 
 
 
 
Screening(340)
 
 
 
Literature(89)
 
 
 
 
 
Summary(72)
 
 
 
BioActivity Types:
Potency(441)
 
 
 
 
 
IC50(18)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 654    Data Row: 974   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103378318]
IC50 1.1Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay [AID390722, Type: Literature]Hormone-sensitive lipase [gi:85690847]
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2
[SID144208535]
Potency-Replicate_1 48.7059qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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3
[SID103378318]
Antihypertensive activity in Std:ddY mouse assessed as inhibition of increase of angiotensin 2-induced systolic arterial pressure at 2 and 10 mg/kg, po after 30 mins [AID362097, Type: Literature]
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4
[SID26753738]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
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5
[SID46391754]
Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Porcine Odorant Binding Protein Complexed With Benzoic Acid Phenylmethylester [gi:12084613]
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6
[SID103378318]
IC50 90Compound was tested for the inhibition of beta-lactamase [AID43431, Type: Literature]
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7
[SID103378318]
IC50 125Inhibition of malate dehydrogenase (MDH) [AID106801, Type: Literature]
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8
[SID103378318]
IC50 250Compound was tested for the inhibition of Chymotrypsinogen [AID52776, Type: Literature]
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9
[SID103378318]
Fold decrease in IC50 vs chymotrypsinogen on pre-incubation [AID52778, Type: Literature]
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10
[SID103378318]
Fold decrease in IC50 vs malate dehydrogenase (MDH) on pre-incubation [AID106656, Type: Literature]
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11
[SID103378318]
Fold increase in IC50 vs malate dehydrogenase (MDH) with 1 mg/ml saponin [AID106799, Type: Literature]
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12
[SID103378318]
Fold increase in IC50 vs beta-lactamase with 10x increased enzyme [AID218572, Type: Literature]
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13
[SID103378318]
Fold increase in IC50 vs beta-lactamaase with 1 mg/mL saponin [AID218693, Type: Literature]
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14
[SID103378318]
Topical dosage on sterol scabies [AID235784, Type: Literature]
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15
[SID103378318]
Pesticidal activity against Dermatophagoides pteronyssinus after 24 hrs [AID355880, Type: Literature]
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16
[SID103378318]
Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracellular calcium uptake [AID362091, Type: Literature]
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17
[SID103378318]
Cytotoxicity against HEK293T cells expressing HA-tagged mouse AT1a angiotensin 2 receptor up to 100 ug/ml after 24 hrs by trypan blue dye exclusion assay [AID362092, Type: Literature]
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18
[SID103378318]
Displacement of [125I]angiotensin 2 from AT1 angiotensin 2 receptor expressed in CHO cells at 100 uM [AID362093, Type: Literature]
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19
[SID103378318]
Displacement of [125I]angiotensin 2 from AT1 angiotensin 2 receptor expressed in CHO cells at 300 uM [AID362094, Type: Literature]
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20
[SID103378318]
Displacement of [125I]CGP-42112A from AT2 angiotensin 2 receptor expressed in HeLa cells at 100 uM [AID362095, Type: Literature]
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21
[SID103378318]
Displacement of [125I]CGP-42112A from AT2 angiotensin 2 receptor expressed in HeLa cells at 300 uM [AID362096, Type: Literature]
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22
[SID26753738]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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23
[SID8149871]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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24
[SID8149871]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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25
[SID8149871]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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26
[SID8149871]
Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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27
[SID8149871]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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28
[SID8149871]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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29
[SID8149871]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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30
[SID8149871]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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31
[SID103378318]
Fold decrease in IC50 vs beta-lactamase on pre-incubation [AID43563, Type: Literature]
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32
[SID103378318]
Fold increase in IC50 vs chymotrypsinogen with 0.2 mg/ml saponin [AID52773, Type: Literature]
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33
[SID47193672]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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34
[SID8149871]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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35
[SID8149871]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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36
[SID8149871]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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37
[SID144204925]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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38
[SID103378318]
Inhibition of HSL in Wistar rat isolated fat cells at 10 uM by spectrophotometric assay [AID390724, Type: Literature]Hormone-sensitive lipase [gi:85690847]
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39
[SID144208535]
Potency-Replicate_1 0.9718qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway [AID743065, Type: confirmatory]thyroid hormone receptor beta isoform 2 [Rattus norvegicus] [gi:399498506]
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40
[SID26748657]
Potency 1.7783qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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41
[SID47193672]
Potency 3.1623qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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42
[SID144208535]
Potency-Replicate_1 24.6253qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway [AID743069, Type: confirmatory]estrogen nuclear receptor alpha [Homo sapiens] [gi:348019627]
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43
[SID144204925]
Potency-Replicate_1 33.4915qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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44
[SID26753738]
Potency 39.8107qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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45
[SID47193672]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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46
[SID47193672]
Potency 56.2341HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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47
[SID26748657]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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48
[SID26748657]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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49
[SID26748657]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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50
[SID26753738]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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