benzyl benzoate (CID 2345) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(558)
 
 
Inconclusive(36)
 
 
Unspecified(33)
 
 
Top Targets:
7TM GPCR Srx(10)
 
 
NR LBD TR(6)
 
 
TRP 2(5)
 
 
7TM GPCR Srsx(5)
 
 
NR LBD VDR(5)
 
 
BioAssay Types:
Screening(293)
 
 
 
Confirmatory(187)
 
 
 
 
Literature(89)
 
 
 
 
 
BioActivity Types:
Potency(167)
 
 
 
 
IC50(18)
 
 
 
 
EC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 530    Data Row: 631   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103378318]
IC50 1.1Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay [AID390722, Type: Literature]Hormone-sensitive lipase [gi:85690847]
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2
[SID46391754]
 Experimentally measured binding affinity data derived from PDB [AID1811, Type: Literature]Chain A, Porcine Odorant Binding Protein Complexed With Benzoic Acid Phenylmethylester [gi:12084613]
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3
[SID103378318]
 Antihypertensive activity in Std:ddY mouse assessed as inhibition of increase of angiotensin 2-induced systolic arterial pressure at 2 and 10 mg/kg, po after 30 mins [AID362097, Type: Literature]
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4
[SID26753738]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_58, Type: Literature]
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5
[SID103378318]
IC50 90Compound was tested for the inhibition of beta-lactamase [AID43431, Type: Literature]Beta-lactamase [gi:113726]
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6
[SID103378318]
IC50 125Inhibition of malate dehydrogenase (MDH) [AID106801, Type: Literature]
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7
[SID103378318]
IC50 250Compound was tested for the inhibition of Chymotrypsinogen [AID52776, Type: Literature]
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8
[SID103378318]
 Fold decrease in IC50 vs chymotrypsinogen on pre-incubation [AID52778, Type: Literature]
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9
[SID103378318]
 Fold decrease in IC50 vs malate dehydrogenase (MDH) on pre-incubation [AID106656, Type: Literature]
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10
[SID103378318]
 Fold increase in IC50 vs malate dehydrogenase (MDH) with 1 mg/ml saponin [AID106799, Type: Literature]
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11
[SID103378318]
 Fold increase in IC50 vs chymotrypsinogen with 0.2 mg/ml saponin [AID52773, Type: Literature]
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12
[SID103378318]
 Fold increase in IC50 vs beta-lactamase with 10x increased enzyme [AID218572, Type: Literature]Beta-lactamase [gi:113726]
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13
[SID144204925]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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14
[SID47193672]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID47193672]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID103378318]
 Fold increase in IC50 vs beta-lactamaase with 1 mg/mL saponin [AID218693, Type: Literature]
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17
[SID103378318]
 Topical dosage on sterol scabies [AID235784, Type: Literature]
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18
[SID103378318]
 Pesticidal activity against Dermatophagoides pteronyssinus after 24 hrs [AID355880, Type: Literature]
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19
[SID103378318]
 Antagonist activity at HA-tagged mouse AT1a angiotensin 2 receptor expressed in HEK293T cells assessed as decrease in angiotensin 2-induced intracellular calcium uptake [AID362091, Type: Literature]
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20
[SID103378318]
 Cytotoxicity against HEK293T cells expressing HA-tagged mouse AT1a angiotensin 2 receptor up to 100 ug/ml after 24 hrs by trypan blue dye exclusion assay [AID362092, Type: Literature]
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21
[SID103378318]
 Displacement of [125I]angiotensin 2 from AT1 angiotensin 2 receptor expressed in CHO cells at 100 uM [AID362093, Type: Literature]
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22
[SID103378318]
 Displacement of [125I]angiotensin 2 from AT1 angiotensin 2 receptor expressed in CHO cells at 300 uM [AID362094, Type: Literature]
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23
[SID103378318]
 Displacement of [125I]CGP-42112A from AT2 angiotensin 2 receptor expressed in HeLa cells at 100 uM [AID362095, Type: Literature]
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24
[SID103378318]
 Displacement of [125I]CGP-42112A from AT2 angiotensin 2 receptor expressed in HeLa cells at 300 uM [AID362096, Type: Literature]
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25
[SID8149871]
 Screen for compounds that induce the human heat shock transcriptional response (HSEluc) [AID1611, Type: other]
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26
[SID8149871]
 Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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27
[SID8149871]
 Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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28
[SID8149871]
 Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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29
[SID8149871]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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30
[SID8149871]
 Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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31
[SID8149871]
 Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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32
[SID8149871]
 Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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33
[SID8149871]
 Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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34
[SID8149871]
 Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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35
[SID8149871]
 Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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36
[SID26753738]
 qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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37
[SID103378318]
 Fold decrease in IC50 vs beta-lactamase on pre-incubation [AID43563, Type: Literature]Beta-lactamase [gi:113726]
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38
[SID103378318]
 Inhibition of HSL in Wistar rat isolated fat cells at 10 uM by spectrophotometric assay [AID390724, Type: Literature]Hormone-sensitive lipase [gi:85690847]
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39
[SID26753738]
Potency 39.8107qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction [AID2662, Type: confirmatory]MLL gene product [Homo sapiens] [gi:56550039]
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40
[SID47193672]
Potency 50.1187qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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41
[SID47193672]
Potency 56.2341HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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42
[SID47193672]
 uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COPS5 gene product [Homo sapiens] [gi:38027923]
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43
[SID47193672]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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44
[SID47193672]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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45
[SID47193672]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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46
[SID47193672]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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47
[SID47193672]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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48
[SID47193672]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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49
[SID47193672]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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50
[SID47193672]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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