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T0501-6954 (CID 2320898) - Compound BioActivity Data
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BioActivity Outcomes:
Active(78)
 
 
Inactive(551)
 
 
Inconclusive(30)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(15)
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(430)
 
 
 
 
Confirmatory(199)
 
 
 
 
 
Literature(13)
 
 
BioActivity Types:
Potency(143)
 
 
 
 
 
IC50(41)
 
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 594    Data Row: 660   Total Pages: 33   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24830300]
Potency 0.2909A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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2
[SID24830300]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID24830300]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID24830300]
Potency 0.5805qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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5
[SID24830300]
Potency 0.6513qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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6
[SID24830300]
Potency 1.2589qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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7
[SID24830300]
Potency 1.4125VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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8
[SID24830300]
Potency 2.2387qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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9
[SID24830300]
Potency 2.3109A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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10
[SID24830300]
Absolute IC50 (CHOP) 2.49CHOP dose-response primary assay [AID504322, Type: confirmatory]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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11
[SID24830300]
Potency 2.6169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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12
[SID24830300]
Absolute IC50 (XBP1) 2.68XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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13
[SID24830300]
Potency 2.8184qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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14
[SID24830300]
Potency 3.9811qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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15
[SID24830300]
Potency 4.4668qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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16
[SID24830300]
Potency 4.609qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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17
[SID24830300]
Potency 8.9125qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID24830300]
Potency 10qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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19
[SID24830300]
Potency 11.9173qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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20
[SID24830300]
Potency 15.8489qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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