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N-Methylaspartate (CID 22880) - Compound BioActivity Data
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BioActivity Outcomes:
Active(38)
 
 
Inactive(777)
 
 
Inconclusive(42)
 
 
Unspecified(35)
 
 
Top Targets:
7tm 4(34)
 
 
 
p450(12)
 
 
 
PLDc mTdp1 2(9)
 
 
ANK(9)
 
 
PBP1 iGluR NM..(9)
 
 
 
BioAssay Types:
Confirmatory(404)
 
 
 
 
 
Screening(366)
 
 
 
 
Literature(60)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(339)
 
 
 
 
 
IC50(31)
 
 
 
 
EC50(12)
 
 
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 699    Data Row: 892   Total Pages: 45   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11111449]
Potency 0.7943qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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2
[SID103223264]
IC50 4.15Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor [AID144612, Type: Literature]
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3
[SID103223264]
Ki 4.2Displacement of [3H]CGS19755 from excitatory NMDA receptor [AID337885, Type: Literature]
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4
[SID103223264]
IC50 4.55Compound was tested for inhibition of [3H]CPP binding from N-methyl-D-aspartate glutamate receptor in the rat cortical membranes. [AID144747, Type: Literature]
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5
[SID103223264]
IC50 5.5Compound was evaluated for the inhibition of [3H]CGS-19,755 binding to NMDA receptor from rat brain synaptic membrane. [AID144837, Type: confirmatory]
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6
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 3B [gi:51701630]
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7
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 3A [gi:51701631]
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8
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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9
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2C [gi:548374]
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10
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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11
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2A [gi:3915771]
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12
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2D [gi:18202594]
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13
[SID103223264]
Ki 6.2Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membranes [AID478464, Type: Literature]
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14
[SID103223264]
EC50 6.86Compound was evaluated for the inhibition of [3H]MK-801 binding at N-methyl-D-aspartate glutamate receptor [AID144321, Type: Literature]
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15
[SID103223264]
EC50 8.3Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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16
[SID103223264]
EC50 9Effective concentration against NR1/NR2A receptor [AID146063, Type: Literature]
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17
[SID103223264]
EC50 11Electropharmacology on rat cortical slice preparation for EAA-evoked depolarizations; Depolarization evoked by the compound is antagonised by 10 uM of CPP. [AID196567, Type: Literature]
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18
[SID103223264]
ED50 15Effective dose against rat cortical slice cells using Electrophysiological experiment. [AID177860, Type: Literature]
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19
[SID103223264]
ED50 15Agonistic activity against N-methyl-D-aspartate glutamate receptor was determined in rat cortical slice preparation at concentration up to 5 mM [AID144324, Type: Literature]
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20
[SID103223264]
EC50 20Effective concentration against NR1/NR2A receptor [AID146059, Type: Literature]
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