N-Methylaspartate (CID 22880) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(28)
 
 
Inactive(665)
 
 
Inconclusive(42)
 
 
Unspecified(33)
 
 
Top Targets:
p450(13)
 
 
 
 
7TM GPCR Srx(13)
 
 
HELICc(8)
 
 
PBP1 iGluR NM..(8)
 
 
 
PLN02808(8)
 
 
BioAssay Types:
Confirmatory(352)
 
 
 
 
 
Screening(307)
 
 
 
 
Literature(43)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(292)
 
 
 
 
 
IC50(25)
 
 
 
 
EC50(12)
 
 
 
 
Ki(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 649    Data Row: 768   Total Pages: 16   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID11111449]
Potency 0.7943qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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2
[SID11111449]
Potency 0.7943qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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3
[SID11111449]
Potency 0.7943qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor [AID926, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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4
[SID103223264]
IC50 4.15Compound was evaluated for the inhibition of [3H]-CGS-19,755 binding at N-methyl-D-aspartate glutamate receptor [AID144612, Type: Literature]
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5
[SID103223264]
Ki 4.2Displacement of [3H]CGS19755 from excitatory NMDA receptor [AID337885, Type: other]
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6
[SID103223264]
IC50 4.55Compound was tested for inhibition of [3H]CPP binding from N-methyl-D-aspartate glutamate receptor in the rat cortical membranes. [AID144747, Type: Literature]
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7
[SID103223264]
IC50 5.5Compound was evaluated for the inhibition of [3H]CGS-19,755 binding to NMDA receptor from rat brain synaptic membrane. [AID144837, Type: other]
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8
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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9
[SID103223264]
IC50 6Inhibition of [3H]CPP binding to N-methyl-D-aspartate glutamate receptor of rat cortical or hippocampal membranes [AID144762, Type: Literature]Glutamate receptor ionotropic, NMDA 2B [gi:548372]
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10
[SID103223264]
Ki 6.2Displacement of [3H]CGP39653 from NMDA receptor in Sprague-Dawley rat brain membranes [AID478464, Type: Literature]
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11
[SID103223264]
EC50 6.86Compound was evaluated for the inhibition of [3H]MK-801 binding at N-methyl-D-aspartate glutamate receptor [AID144321, Type: Literature]
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12
[SID103223264]
EC50 8.3Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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13
[SID103223264]
EC50 8.3Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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14
[SID103223264]
EC50 8.3Activity at rat NR1/NR2D receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339883, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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15
[SID103223264]
EC50 9Effective concentration against NR1/NR2A receptor [AID146063, Type: Literature]
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16
[SID103223264]
EC50 11Electropharmacology on rat cortical slice preparation for EAA-evoked depolarizations; Depolariztion evoked by the compound is antagonised by 10 uM of CPP. [AID196567, Type: Literature]
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17
[SID103223264]
ED50 15Effective dose against rat cortical slice cells using Electrophysiological experiment. [AID177860, Type: Literature]
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18
[SID103223264]
ED50 15Agonistic activity against N-methyl-D-aspartate glutamate receptor was determined in rat cortical slice preparation at concentration up to 5 mM [AID144324, Type: Literature]
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19
[SID103223264]
EC50 20Effective concentration against NR1/NR2A receptor [AID146059, Type: Literature]
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20
[SID103223264]
EC50 22Effective concentration against NR1/NR2A receptor [AID146061, Type: Literature]
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21
[SID103223264]
EC50 22Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339882, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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22
[SID103223264]
EC50 22Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339882, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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23
[SID103223264]
EC50 22Activity at rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339882, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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24
[SID90341063]
Potency 22.3872qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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25
[SID46500421]
Potency 22.3872qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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26
[SID103223264]
EC50 23Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339885, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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27
[SID103223264]
EC50 23Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339885, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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28
[SID103223264]
EC50 23Activity at rat recombinant NR1/NR2C receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339885, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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29
[SID11113384]
Potency 25.1189qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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30
[SID103223264]
IC50 35Inhibitory activity against N-methyl-D-aspartate glutamate receptor using [3H]CPP as radioligand [AID144902, Type: Literature]
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31
[SID103223264]
EC50 36Effective concentration against NR1/NR2A receptor [AID146058, Type: Literature]
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32
[SID11113384]
Potency 100qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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33
[SID103223264]
 Binding affinity for glutamate-stimulated TCP binding site of N-methyl-D-aspartate glutamate receptor from rat brain by using [3H]-TCP as radioligand; ag = agonist [AID144333, Type: Literature]
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34
[SID46500421]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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35
[SID8150019]
 Screen for compounds that attenuate mutant SOD1 toxicity (mSOD1) [AID1602, Type: other]
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36
[SID46500421]
 Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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37
[SID56320631]
 Fluorescence-based biochemical primary high throughput screening assay to identify inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493244, Type: screening]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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38
[SID103223264]
EC50 75Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339880, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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39
[SID103223264]
EC50 75Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339880, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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40
[SID103223264]
EC50 75Activity at rat recombinant NR1/NR2A receptor expressed in Xenopus oocytes assessed as effect on glutamate-induced current by two voltage clamp electrophysiology [AID339880, Type: Literature]Glutamate receptor ionotropic, NMDA 1 [gi:548379]
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41
[SID103223264]
EC50 75Compound was evaluated for the inhibition of [3H]norepinephrine binding at N-methyl-D-aspartate glutamate receptor [AID144322, Type: Literature]
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42
[SID103223264]
IC50 100Compound was evaluated for the inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA from rat brain synaptic membrane. [AID92356, Type: other]
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43
[SID103223264]
IC50 100Inhibitory activity against Ionotropic glutamate receptor AMPA using [3H]AMPA as radioligand [AID92499, Type: Literature]
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44
[SID103223264]
IC50 100Compound was evaluated for the inhibition of [3H]-KA binding to Ionotropic glutamate receptor kainate from rat brain synaptic membrane. [AID93572, Type: other]
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45
[SID103223264]
IC50 100Inhibitory activity against Ionotropic glutamate receptor kainate using [3H]-kainic acid as radioligand [AID93720, Type: Literature]
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46
[SID103223264]
IC50 100Displacement of [3H]AMPA from AMPA receptor in Sprague-Dawley rat brain membranes [AID478462, Type: Literature]
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47
[SID103223264]
IC50 100Displacement of [3H]KA from KA receptor in Sprague-Dawley rat brain membranes [AID478463, Type: Literature]
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48
[SID103223264]
 Repolarization time for compound was measured by pattern firing by APN and KVN blockade [AID205942, Type: Literature]
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49
[SID103223264]
 Effect of compound on cell viability in non-transformed neuronal/glial cells measured as percent reduction of MTT at 570 nm O.D. at 100 uM; Control value 0.56 % [AID252416, Type: Literature]
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50
[SID103223264]
 Agonistic activity at N-methyl-D-aspartate glutamate receptor was measured as [Ca2+] influx in rat cerebellar granule neurons at 100 uM concentration [AID144185, Type: Literature]
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