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Baclofen (CID 2284) - Compound BioActivity Data
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BioActivity Outcomes:
Active(37)
 
 
Inactive(632)
 
 
Inconclusive(43)
 
 
Unspecified(591)
 
 
Top Targets:
7TM GPCR Srx(25)
 
 
 
 
PBP1 GABAb re..(20)
 
 
 
7TM GPCR Srsx(20)
 
 
 
 
Neur chan LBD(14)
 
 
NR LBD ER(13)
 
 
 
BioAssay Types:
Confirmatory(525)
 
 
 
 
 
Literature(211)
 
 
 
 
Screening(126)
 
 
Summary(25)
 
 
BioActivity Types:
Potency(389)
 
 
 
 
 
IC50(160)
 
 
 
 
EC50(10)
 
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1054    Data Row: 1303   Total Pages: 66   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103194022]
IC50 0.03Displacement of [3H]GABA from Gamma-aminobutyric acid A (GABA-A) receptor in rat brain membranes [AID72152, Type: Literature]
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2
[SID103194022]
IC50 0.03In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes [AID71389, Type: confirmatory]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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3
[SID103194022]
IC50 0.03In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes [AID71389, Type: confirmatory]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
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4
[SID103194022]
IC50 0.035Inhibition of [3H]-baclofen binding to Gamma-aminobutyric acid type B receptor of cat cerebellum [AID71258, Type: Literature]
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5
[SID103194022]
IC50 0.05Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECA [AID255079, Type: Literature]Adenosine receptor A3 [gi:1351831]
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6
[SID103194022]
IC50 0.06Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranes [AID71395, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
View
7
[SID103194022]
IC50 0.06Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor in rat brain membranes [AID71395, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
View
8
[SID103194022]
IC50 0.107Inhibition of [3H]CGP-27492 binding to Gamma-aminobutyric acid type B receptor of rat cortex [AID71401, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
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9
[SID103194022]
IC50 0.107Inhibition of [3H]CGP-27492 binding to Gamma-aminobutyric acid type B receptor of rat cortex [AID71401, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
View
10
[SID103194022]
IC50 0.2Binding affinity against Gamma-aminobutyric acid type B receptor in rat brain synaptosomes after 30 minutes [AID71398, Type: confirmatory]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
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11
[SID103194022]
IC50 0.2Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranes [AID71399, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
View
12
[SID103194022]
IC50 0.2Displacement of [3H]baclofen from Gamma-aminobutyric acid type B receptor of rat brain membranes [AID71399, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
View
13
[SID103194022]
IC50 0.2Binding affinity against Gamma-aminobutyric acid type B receptor in rat brain synaptosomes after 30 minutes [AID71398, Type: confirmatory]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
View
14
[SID103194022]
Ki 0.22Displacement of [3H]GABA from GABABreceptor in rat brain synaptic membranes [AID339808, Type: Literature]
View
15
[SID103194022]
IC50 0.33Inhibition of [3H]baclofen binding to rat gamma-aminobutyric acid type B receptor. [AID71390, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
View
16
[SID103194022]
IC50 0.33Inhibition of [3H]baclofen binding to rat gamma-aminobutyric acid type B receptor. [AID71390, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
View
17
[SID103194022]
IC50 0.36Competitive inhibition of rat brain GABAB receptor after 30 mins by liquid scintillation counting analysis in presence of [3H]GABA [AID764972, Type: Literature]
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18
[SID103194022]
IC50 0.42Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor [AID71388, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 2 [gi:12643481]
View
19
[SID103194022]
IC50 0.42Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptor [AID71388, Type: Literature]Gamma-aminobutyric acid type B receptor subunit 1 [gi:12643494]
View
20
[SID103194022]
EC50 0.75Agonist activity at human recombinant GABABreceptor expressed in CHO-K1 cells assessed as inhibition of intracellular calcium release by FLIPR [AID339809, Type: Literature]
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