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AC1M4OQX (CID 2263521) - Compound BioActivity Data
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BioActivity Outcomes:
Active(57)
 
 
Inactive(572)
 
 
Inconclusive(36)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(18)
 
 
Tryp SPc(8)
 
 
Bcl-2 like(8)
 
 
KCNQ channel(8)
 
 
 
BioAssay Types:
Screening(424)
 
 
 
 
Confirmatory(204)
 
 
 
 
 
Literature(20)
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(44)
 
 
 
 
EC50(8)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 593    Data Row: 666   Total Pages: 34   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24790714]
IC50 1.123Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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2
[SID24790714]
IC50 1.123Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) (2K validation set) [AID504319, Type: confirmatory]perilipin-5 [Homo sapiens] [gi:116292172]
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3
[SID24790714]
IC50 1.227Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]perilipin-1 [Homo sapiens] [gi:223718203]
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4
[SID24790714]
IC50 1.227Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) (2K validation set) [AID504317, Type: confirmatory]1-acylglycerol-3-phosphate O-acyltransferase ABHD5 [Homo sapiens] [gi:31542303]
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5
[SID24790714]
Potency 1.6834qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID24790714]
Potency 2.8184qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID24790714]
Potency 2.9362Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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8
[SID24790714]
Potency 3.5481qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID24790714]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID24790714]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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11
[SID24790714]
Potency 4.6109qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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12
[SID24790714]
Potency 5.1735A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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13
[SID24790714]
Potency 9.2qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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14
[SID24790714]
Potency 10qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]neuropeptide S receptor isoform A [Homo sapiens] [gi:46395496]
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15
[SID24790714]
Potency 12.5893qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID24790714]
Potency 12.9953qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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17
[SID24790714]
Potency 14.1254qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID24790714]
Potency 14.1254qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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19
[SID24790714]
Potency 25.1189qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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20
[SID24790714]
Potency 28.1838qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase) [AID1490, Type: confirmatory]phosphopantetheinyl transferase [Bacillus subtilis] [gi:10954339]
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