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MLS000948011 (CID 22524940) - Compound BioActivity Data
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BioActivity Outcomes:
Active(134)
 
 
Inactive(383)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(37)
 
 
 
Esterase lipa..(6)
 
 
 
WD40(6)
 
 
 
TRP 2(5)
 
 
HSF(5)
 
 
 
BioAssay Types:
Screening(340)
 
 
 
 
Confirmatory(189)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(122)
 
 
 
 
 
IC50(42)
 
 
 
EC50(15)
 
 
 
 
AC50(8)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 496    Data Row: 545   Total Pages: 28   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49716126]
EC50_uM 0.306Fluorescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of RecA-Intein Splicing Activity [AID435010, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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2
[SID49716126]
AC50_uM 0.4164Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Inhibitors of DnaB-Intein Splicing Activity [AID449749, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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3
[SID49716126]
EC50_uM 0.498Fluorescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of GFP Chromophore Formation [AID434968, Type: confirmatory]recombinase A [Mycobacterium tuberculosis H37Rv] [gi:15609874]
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4
[SID49716126]
AC50_uM 0.5603Fluorescence Cell-Free Homogeneous Secondary Screen to Identify Non-Covalent Inhibitors of RecA-Intein Splicing Activity [AID449750, Type: confirmatory]replicative DNA helicase [Mycobacterium tuberculosis H37Rv] [gi:15607200]
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5
[SID49716126]
Potency 0.7375Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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6
[SID49716126]
Potency 0.8913qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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7
[SID49716126]
AC50_uM 0.9808Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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8
[SID49716126]
IC50_Mean 1.1Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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9
[SID49716126]
Potency 1.122qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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10
[SID49716126]
EC50 1.162Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1) [AID2382, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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11
[SID49716126]
IC50 1.283Luminescence-based dose response biochemical high throughput screening assay for inhibitors of the Heat Shock Protein 90 (HSP90) [AID1913, Type: confirmatory]HSP90AA1 protein, partial [Homo sapiens] [gi:83318444]
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12
[SID49716126]
Potency 1.4125qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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13
[SID49716126]
EC50 1.506Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity [AID1902, Type: confirmatory]streptokinase A [Streptococcus pyogenes M1 GAS] [gi:15675770]
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14
[SID49716126]
EC50 1.513Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast [AID1933, Type: confirmatory]
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15
[SID49716126]
AC50_uM 1.743HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493083, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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16
[SID49716126]
AC50_uM 1.831HSF-1 induced GFP reporter and Doxycycline induced RFP reporter Measured in Cell-Based System Using Plate Reader - 2038-03_Inhibitor_DoseNoFile_CherryPick_Internal-Standard_Set3 [AID493085, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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17
[SID49716126]
EC50 1.858Luminescence Microorganism-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to SK(-)GAS Group A Streptococcus [AID1900, Type: confirmatory]
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18
[SID49716126]
IC50_Mean 1.97Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay [AID588524, Type: confirmatory]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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19
[SID49716126]
IC50_Mean 2.07Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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20
[SID49716126]
IC50_Mean 2.07Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay [AID588574, Type: confirmatory]caspase-9 isoform alpha precursor [Homo sapiens] [gi:14790124]
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