Bookmark and Share
Arecoline (CID 2230) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(138)
 
 
Inactive(463)
 
 
Inconclusive(20)
 
 
Unspecified(125)
 
 
Top Targets:
7TM GPCR Srx(71)
 
 
 
 
 
p450(20)
 
 
HSD10-like SD..(8)
 
 
NR LBD GR(8)
 
 
NR LBD PPAR(8)
 
 
 
BioAssay Types:
Confirmatory(370)
 
 
 
 
 
Literature(287)
 
 
 
 
 
Summary(24)
 
 
 
Screening(14)
 
 
BioActivity Types:
Potency(317)
 
 
 
IC50(83)
 
 
 
 
Ki(37)
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 511    Data Row: 746   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
View
2
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
View
3
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:113130]
View
4
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:113132]
View
5
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
View
6
[SID103164643]
Km 0.0024Binding affinity (medium) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M2 expressed in A9 L cell line [AID142667, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:341940175]
View
7
[SID103164643]
Ki 0.00333Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-S [AID141434, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:408359949]
View
8
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:113132]
View
9
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
View
10
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:113130]
View
11
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
View
12
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
View
13
[SID103164643]
Ki 0.00545Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-S [AID141435, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:408359949]
View
14
[SID103164643]
Ki 0.0074Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]OXO-M (oxotremorine) as the radioligand. [AID142349, Type: Literature]
View
15
[SID103164643]
Ki 0.014Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranes [AID141179, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
View
16
[SID103164643]
IC50 0.016In vitro binding affinity to the Muscarinic acetylcholine receptor by displacing [3H]- Oxo-M from the rat brain tissues [AID141661, Type: Literature]
View
17
[SID103164643]
IC50 0.02Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue. [AID141540, Type: Literature]
View
18
[SID103164643]
IC50 0.024Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand [AID225548, Type: Literature]
View
19
[SID103164643]
EC50 0.025In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT). [AID142379, Type: Literature]
View
20
[SID103164643]
Ki 0.026Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes [AID141886, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
View