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Arecoline (CID 2230) - Compound BioActivity Data
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BioActivity Outcomes:
Active(137)
 
 
Inactive(457)
 
 
Inconclusive(24)
 
 
Unspecified(121)
 
 
Top Targets:
7TM GPCR Srx(71)
 
 
 
 
 
p450(20)
 
 
HSD10-like SD..(8)
 
 
NR LBD PPAR(8)
 
 
 
NR LBD GR(8)
 
 
 
BioAssay Types:
Confirmatory(347)
 
 
 
Literature(284)
 
 
 
 
 
Summary(24)
 
 
 
Screening(14)
 
 
BioActivity Types:
Potency(315)
 
 
 
IC50(83)
 
 
 
 
Ki(35)
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 505    Data Row: 739   Total Pages: 15   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
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2
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
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3
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:113130]
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4
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:113132]
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5
[SID103164643]
IC50 0.0019Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptor [AID141541, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
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6
[SID103164643]
Km 0.0024Binding affinity (medium) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M2 expressed in A9 L cell line [AID142667, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:341940175]
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7
[SID103164643]
Ki 0.00333Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-S [AID141434, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:408359949]
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8
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
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9
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:113132]
View
10
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:113130]
View
11
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
View
12
[SID103164643]
Ki 0.0053Inhibition of [3H]- oxotremorine-M binding to Muscarinic acetylcholine receptor of rat heart membranes. [AID142346, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
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13
[SID103164643]
Ki 0.00545Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-S [AID141435, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:408359949]
View
14
[SID103164643]
Ki 0.0074Binding affinity against muscarinic acetylcholine receptor from rat brain crude membrane, using [3H]OXO-M (oxotremorine) as the radioligand. [AID142349, Type: Literature]
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15
[SID103164643]
Ki 0.014Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranes [AID141179, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
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16
[SID103164643]
IC50 0.016In vitro binding affinity to the Muscarinic acetylcholine receptor by displacing [3H]- Oxo-M from the rat brain tissues [AID141661, Type: Literature]
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17
[SID103164643]
IC50 0.02Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue. [AID141540, Type: Literature]
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18
[SID103164643]
IC50 0.024Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligand [AID225548, Type: Literature]
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19
[SID103164643]
EC50 0.025In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT). [AID142379, Type: Literature]
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20
[SID103164643]
Ki 0.026Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranes [AID141886, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:23503039]
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21
[SID103164643]
Ki 0.031The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M to muscarinic acetylcholine receptor in rat cerebral cortical membranes. [AID142343, Type: Literature]
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22
[SID103164643]
Ki 0.04The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cells [AID142531, Type: Literature]
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23
[SID103164643]
Ki 0.04Binding affinity for muscarinic receptor site in rat hippocampus was determined using competitive radioligand binding assays employing [3H]OXO-M [AID140972, Type: other]
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24
[SID103164643]
Ki 0.04Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membrane [AID142532, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:113122]
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25
[SID103164643]
Ki 0.04Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine receptor M2 [AID142529, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:113122]
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26
[SID103164643]
Ki 0.04Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranes [AID142958, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
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27
[SID103164643]
IC50 0.0627In vitro Binding affinity was measured against Muscarinic acetylcholine receptor on rat brain membranes using [3H]oxotremorine-M [AID141552, Type: Literature]
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28
[SID103164643]
EC50 0.073Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum. [AID75929, Type: Literature]
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29
[SID103164643]
IC50 0.077In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligand [AID141559, Type: Literature]
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30
[SID103164643]
IC50 0.077In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand. [AID141550, Type: Literature]
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31
[SID103164643]
IC50 0.077Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand. [AID141574, Type: Literature]
View
32
[SID103164643]
IC50 0.077Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1 [AID141565, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
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33
[SID103164643]
IC50 0.077Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes [AID142833, Type: other]Muscarinic acetylcholine receptor M2 [gi:12643977]
View
34
[SID103164643]
IC50 0.077Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes [AID142833, Type: other]Muscarinic acetylcholine receptor M3 [gi:113127]
View
35
[SID103164643]
IC50 0.077Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes [AID142833, Type: other]Muscarinic acetylcholine receptor M4 [gi:113130]
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36
[SID103164643]
IC50 0.077Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes [AID142833, Type: other]Muscarinic acetylcholine receptor M1 [gi:113121]
View
37
[SID103164643]
IC50 0.077Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranes [AID142833, Type: other]Muscarinic acetylcholine receptor M5 [gi:113132]
View
38
[SID103164643]
EC50 0.083In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenate [AID142742, Type: Literature]
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39
[SID103164643]
EC50 0.1Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropine [AID141130, Type: Literature]
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40
[SID103164643]
IC50 0.115In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptor [AID141529, Type: Literature]
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41
[SID103164643]
IC50 0.115In vitro affinity evaluated using [3H]- oxotremorine as radioligand in rat cerebral cortex for muscarinic acetylcholine receptor [AID141659, Type: Literature]
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42
[SID103164643]
IC50 0.115Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells. [AID141041, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113118]
View
43
[SID103164643]
IC50 0.115In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates [AID141543, Type: Literature]Muscarinic acetylcholine receptor M4 [gi:113130]
View
44
[SID103164643]
IC50 0.115In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates [AID141543, Type: Literature]Muscarinic acetylcholine receptor M5 [gi:113132]
View
45
[SID103164643]
IC50 0.115In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates [AID141543, Type: Literature]Muscarinic acetylcholine receptor M3 [gi:113127]
View
46
[SID103164643]
IC50 0.115In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates [AID141543, Type: Literature]Muscarinic acetylcholine receptor M1 [gi:113121]
View
47
[SID103164643]
IC50 0.115In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenates [AID141543, Type: Literature]Muscarinic acetylcholine receptor M2 [gi:12643977]
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48
[SID103164643]
IC50 0.12Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]oxotremorine-M (OXO-M); Range is 75-170 [AID142842, Type: other]
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49
[SID103164643]
EC50 0.13In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT) [AID141868, Type: Literature]
View
50
[SID103164643]
EC50 0.14M2/M3 agonist activity estimated by contraction of isolated guinea pig ileum [AID140993, Type: Literature]
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