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BioActivity Data for Compound gamma-sitosterol (CID 222284)

BioActivity Outcomes:
Active(14)
 
 
Inactive(187)
 
 
Inconclusive(3)
 
 
Unspecified(124)
 
 
Top Targets:
NR LBD ER(8)
 
 
NR LBD AR(7)
 
 
p450(4)
 
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
BioAssay Types:
Literature(139)
 
 
 
 
 
Confirmatory(111)
 
 
 
 
 
Summary(15)
 
 
Screening(5)
 
 
BioAssay Categories:
In vitro(5)
 
 
In vivo(8)
 
 
 
Biochemical(19)
 
 
 
 
Toxicity(64)
 
 
 
 
 
ADME(37)
 
 
Cell-based(76)
 
 
 
 
 
BioActivity Types:
Potency(66)
 
 
 
IC50(25)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 321    Data Row: 328   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103507229]
EC50 19Reduction in surface tension in 0.1 M PBS after 10 mins by Wilhelmy plate method using tensitometer [AID658065, Type: Literature]
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2
[SID103507229]
IC50 26.3Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay [AID356610, Type: Literature]
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3
[SID103507229]
IC50 28.84Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay [AID1118023, Type: confirmatory]Dipeptidyl peptidase 4 [gi:1352311]
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4
[SID103507229]
IC50 42.1Cytotoxicity against human MCF7 cells by MTT assay [AID375387, Type: Literature]
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5
[SID103507229]
IC50 46.22Cytotoxicity against human HeLa cells by MTT assay [AID375386, Type: Literature]
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6
[SID103507229]
Induction of GSK3-beta phosphorylation in human HepG2 cells at 10 uM by Western blot analysis in presence of 33 mM glucose [AID437580, Type: Literature]Glycogen synthase kinase-3 beta [gi:20455502]
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7
[SID103507229]
Anxiolytic activity in albino Mus musculus (mouse) assessed as increase in number of open arm enteries at 100 mg/kg, ip administered 30 min prior to testing by elevated-plus maze test relative to control [AID1114576, Type: other]
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8
[SID103507229]
Anxiolytic activity in albino Mus musculus (mouse) assessed as increase in number of open arm enteries at 50 mg/kg, ip administered 30 min prior to testing by elevated-plus maze test relative to control [AID1114577, Type: other]
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9
[SID103507229]
Increase in glycogen synthesis in human HepG2 cells assessed as incorporation of [14C]glucose in to cellular glycogen pools at 10 uM after 60 mins in presence of 33 mM glucose [AID437581, Type: Literature]
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10
[SID103507229]
Induction of glucose uptake in human HepG2 cells at 10 uM in presence of 33 mM 2-[14C]-DOG by scintillation counting [AID437582, Type: Literature]
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11
[SID48416544]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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12
[SID103507229]
Induction of apoptosis in human HT29 cells at 5 uM [AID299890, Type: Literature]
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13
[SID103507229]
Antiproliferative activity against human HT29 cells at 5 uM after 24 hrs by MTT assay [AID299888, Type: Literature]
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14
[SID103507229]
Induction of AMPK phosphorylation in human HepG2 cells at 10 uM by Western blot analysis in presence of 33 mM glucose [AID437579, Type: Literature]
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15
[SID103507229]
IC50 50Cytotoxicity against human SK-MEL-1 cells by MTT assay [AID375388, Type: Literature]
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16
[SID103507229]
IC50 50Antiplasmodial activity against Plasmodium falciparum W2 [AID746436, Type: Literature]
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17
[SID103507229]
IC50 50Antiplasmodial activity against Plasmodium falciparum D6 [AID746437, Type: Literature]
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18
[SID103507229]
IC50 61Cytotoxicity against human ECV304 cells after 72 hrs by MTT assay [AID780290, Type: Literature]
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19
[SID103507229]
IC50 61Cytotoxicity against human ECV304 cells after 72 hrs by Hoechst 33258 staining based fluorescence assay [AID658063, Type: Literature]
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20
[SID103507229]
IC50 100Inhibition of human CYP2D6 by radiometric assay [AID402937, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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