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gamma-sitosterol (CID 222284) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(174)
 
 
Inconclusive(4)
 
 
Unspecified(97)
 
 
Top Targets:
NR LBD ER(8)
 
 
NR LBD AR(7)
 
 
NR LBD GR(4)
 
 
 
p450(4)
 
 
 
NR LBD TR(3)
 
 
BioAssay Types:
Literature(125)
 
 
 
 
 
Confirmatory(108)
 
 
 
 
Summary(15)
 
 
Screening(5)
 
 
BioActivity Types:
Potency(64)
 
 
 
IC50(20)
 
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 279    Data Row: 286   Total Pages: 6   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103507229]
EC50 19Reduction in surface tension in 0.1 M PBS after 10 mins by Wilhelmy plate method using tensitometer [AID658065, Type: Literature]
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2
[SID103507229]
IC50 26.3Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay [AID356610, Type: Literature]
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3
[SID103507229]
IC50 42.1Cytotoxicity against human MCF7 cells by MTT assay [AID375387, Type: Literature]
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4
[SID103507229]
IC50 46.22Cytotoxicity against human HeLa cells by MTT assay [AID375386, Type: Literature]
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5
[SID103507229]
Induction of GSK3-beta phosphorylation in human HepG2 cells at 10 uM by Western blot analysis in presence of 33 mM glucose [AID437580, Type: Literature]Glycogen synthase kinase-3 beta [gi:20455502]
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6
[SID103507229]
Induction of AMPK phosphorylation in human HepG2 cells at 10 uM by Western blot analysis in presence of 33 mM glucose [AID437579, Type: Literature]
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7
[SID103507229]
Increase in glycogen synthesis in human HepG2 cells assessed as incorporation of [14C]glucose in to cellular glycogen pools at 10 uM after 60 mins in presence of 33 mM glucose [AID437581, Type: Literature]
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8
[SID103507229]
Induction of glucose uptake in human HepG2 cells at 10 uM in presence of 33 mM 2-[14C]-DOG by scintillation counting [AID437582, Type: Literature]
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9
[SID48416544]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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10
[SID103507229]
Antiproliferative activity against human HT29 cells at 5 uM after 24 hrs by MTT assay [AID299888, Type: Literature]
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11
[SID103507229]
Induction of apoptosis in human HT29 cells at 5 uM [AID299890, Type: Literature]
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12
[SID103507229]
IC50 50Cytotoxicity against human SK-MEL-1 cells by MTT assay [AID375388, Type: Literature]
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13
[SID103507229]
IC50 61Cytotoxicity against human ECV304 cells after 72 hrs by Hoechst 33258 staining based fluorescence assay [AID658063, Type: Literature]
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14
[SID103507229]
IC50 100Inhibition of human CYP3A4 by radiometric assay [AID402936, Type: Literature]Cytochrome P450 3A4 [gi:116241312]
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15
[SID103507229]
IC50 100Inhibition of human CYP2D6 by radiometric assay [AID402937, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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16
[SID103507229]
IC50 241.1Antitrypanosomal activity against Trypanosoma brucei brucei bloodstream trypomastigotes by alamar blue assay [AID311138, Type: Literature]
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17
[SID103507229]
IC50 241.1Cytotoxicity against mouse J774 cells by alamar blue assay [AID311139, Type: Literature]
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18
[SID103507229]
MIC 400Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks by agar dilution method [AID405575, Type: Literature]
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19
[SID103507229]
MIC 400Antitubercular activity against Mycobacterium tuberculosis 90-221387 [AID278000, Type: Literature]
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20
[SID103507229]
IC50 472Membranolytic activity in human ECV304 cells assessed as leakage of intracellular lactate dehydrogenase after 2 hrs by spectrophotometry [AID658064, Type: Literature]
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21
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as reduction in glucose-6-phosphatase at 20 mg/kg, po qd for 21 days [AID634866, Type: Literature]
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22
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as reduction in glycosylated haemoglobin at 20 mg/kg, po qd for 21 days [AID634867, Type: Literature]
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23
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as increase in plasma insulin level at 20 mg/kg, po qd for 21 days [AID634868, Type: Literature]
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24
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as increase in liver glycogen at 20 mg/kg, po qd for 21 days [AID634869, Type: Literature]
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25
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as increase in muscle glycogen at 20 mg/kg, po qd for 21 days [AID634870, Type: Literature]
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26
[SID103507229]
Antidiabetic activity in STZ-induced diabetic rat model assessed as increase in glucose 6 phosphate dehydrogenase at 20 mg/kg, po qd for 21 days [AID634871, Type: Literature]
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27
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes assessed as cell viability at 100 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to normal hepatocytes [AID359150, Type: Literature]
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28
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes assessed as cell viability at 50 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to normal hepatocytes [AID359151, Type: Literature]
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29
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes assessed as cell viability at 25 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to normal hepatocytes [AID359152, Type: Literature]
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30
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes at 100 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to control [AID359153, Type: Literature]
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31
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes at 50 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to control [AID359154, Type: Literature]
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32
[SID103507229]
Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes at 25 uM treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay relative to control [AID359155, Type: Literature]
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33
[SID103507229]
Cytotoxicity against human HepG2 cells assessed as cell survival at 5 uM after 24 hrs by MTT assay [AID437575, Type: Literature]
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34
[SID103507229]
Cytotoxicity against human HepG2 cells assessed as cell survival at 10 uM after 24 hrs by MTT assay [AID437576, Type: Literature]
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35
[SID103507229]
Cytotoxicity against human HepG2 cells assessed as cell survival at 20 uM after 24 hrs by MTT assay [AID437577, Type: Literature]
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36
[SID103507229]
Cytotoxicity against human HepG2 cells assessed as cell survival at 100 uM after 24 hrs by MTT assay [AID437578, Type: Literature]
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37
[SID103507229]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in humans [AID588211, Type: Literature]
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38
[SID103507229]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in rodents [AID588212, Type: Literature]
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39
[SID103507229]
Literature-mined compound from Fourches et al multi-species drug-induced liver injury (DILI) dataset, effect in non-rodents [AID588213, Type: Literature]
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40
[SID103507229]
Induction of NGF production in rat C6 cells at 20 uM after 24 hrs by ELISA relative to untreated control [AID589667, Type: Literature]
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41
[SID103507229]
Cytotoxicity against rat C6 cells assessed as viable cells at 20 uM after 24 hrs by MTT assay [AID589668, Type: Literature]
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42
[SID103507229]
Antimicrobial activity against Staphylococcus aureus ATCC 9144 after 24 hrs using thiazoyl blue by agar overlay bioautography method [AID614100, Type: Literature]
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43
[SID103507229]
Antimicrobial activity against Bacillus subtilis ATCC 6633 after 24 hrs using thiazoyl blue by agar overlay bioautography method [AID614101, Type: Literature]
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44
[SID103507229]
Antimicrobial activity against Pseudomonas aeruginosa NCTC 10332 after 24 hrs using thiazoyl blue by agar overlay bioautography method [AID614102, Type: Literature]
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45
[SID103507229]
Antimicrobial activity against Candida albicans ATCC 10231 after 24 hrs using thiazoyl blue by agar overlay bioautography method [AID614103, Type: Literature]
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46
[SID103507229]
Antimicrobial activity against Escherichia coli ATCC 11229 after 24 hrs using thiazoyl blue by agar overlay bioautography method [AID614104, Type: Literature]
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47
[SID103507229]
Critical micellar concentration of the compound in 0.1 M PBS after 10 mins by Wilhelmy plate method using tensitometer [AID658066, Type: Literature]
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48
[SID103507229]
TP_TRANSPORTER: inhibition of taurocholate uptake (taurocholate: 2 uM, beta-sitosterol: 10 uM) in membrane vesicles of Bsep-expressing S9f cells [AID681727, Type: other]Bile salt export pump [gi:12585136]
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49
[SID103507229]
Inhibition of electric eel AChE at 2 mg/ml by Ellman's method [AID697852, Type: Literature]Acetylcholinesterase [gi:14916521]
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50
[SID103507229]
Inhibition of horse BChE at 2 mg/ml by Ellman's method [AID697853, Type: Literature]Cholinesterase [gi:21362409]
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