acetovanillone (CID 2214) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Inactive(398)
 
 
Inconclusive(2)
 
 
Unspecified(13)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(291)
 
 
Confirmatory(91)
 
 
 
 
Literature(21)
 
 
 
BioActivity Types:
Potency(78)
 
 
 
 
IC50(13)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 413    Data Row: 413   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103409349]
IC50 1090Inhibition of NADPH oxidase in human HUVEC assessed as inhibition of superoxide anion generation by cytochrome-C reduction assay [AID436595, Type: Literature]
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2
[SID103409349]
IC50 61000Inhibition of p47phox/p22phox interaction by ELISA [AID436598, Type: Literature]
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3
[SID103409349]
 Ability to protect microvascular damages in ischemia/reperfusion (in vivo) was determined by measuring the inhibition of leaky sites, 30-min after the start of reperfusion at 30 mg/kg [AID87266, Type: Literature]
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4
[SID103409349]
 Inhibition of beta-hexosaminidase in anti-DNP IgE sensitized rat RBL2H3 cells at 100 uM after 10 mins [AID333180, Type: Literature]
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5
[SID103409349]
 Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of TNFalpha formation at 30 uM pretreated 1 hr before LPS challenge measured after 24 hrs by enzyme immunoassay [AID360334, Type: Literature]
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6
[SID103409349]
 Antiinflammatory activity in LPS/IFN-gamma-stimulated mouse N9 cells assessed as inhibition of TNFalpha formation at 30 uM pretreated 1 hr before LPS/IFNgamma challenge measured after 24 hrs by enzyme immunoassay [AID360336, Type: Literature]
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7
[SID103409349]
 Antioxidant activity against microvascular damage in hamster model of cheek pouch submitted to ischemia/reperfusion assessed as inhibition of leaky sites at 3 mg/kg treated by gavage route 30 mins before anesthesia measured after 30 mins of reperfusion by FITC-dextran based microscopy [AID430015, Type: Literature]
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8
[SID103409349]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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9
[SID103409349]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs [AID462334, Type: Literature]
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10
[SID103409349]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 3 uM after 72 hrs [AID462335, Type: Literature]
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11
[SID103409349]
 Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 1 uM after 72 hrs [AID462336, Type: Literature]
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12
[SID103409349]
 Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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13
[SID51088030]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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14
[SID51088030]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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15
[SID51088030]
Potency 2.5119qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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16
[SID51088030]
Potency 25.929A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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17
[SID51088030]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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18
[SID51088030]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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19
[SID51088030]
Potency qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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20
[SID51088030]
 Activator for delta FosB/delta FosB homodimer Measured in Biochemical System Using Plate Reader - 2072-01_Activator_SinglePoint_HTS_Activity [AID493131, Type: screening]protein fosB [Mus musculus] [gi:6679827]
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21
[SID51088030]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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22
[SID51088030]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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23
[SID51088030]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). [AID2098, Type: screening]Hsf1 protein [Mus musculus] [gi:62740231]
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24
[SID51088030]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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25
[SID51088030]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of the mouse 5-hydroxytryptamine (serotonin) receptor 2A (HTR2A) [AID624169, Type: screening]Htr2a gene product [Mus musculus] [gi:27753985]
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26
[SID51088030]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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27
[SID51088030]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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28
[SID51088030]
 HTS for developing T Cell Immune Modulators [AID2052, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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29
[SID51088030]
 HTS for developing T Cell Immune Modulators for Cherry Picked Compounds from Primary Screen [AID2810, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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30
[SID51088030]
 HTS for developing T Cell Immune Modulators for Cherry Picked Compounds from Primary Screen [AID2810, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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31
[SID51088030]
 HTS for developing T Cell Immune Modulators for Cherry Picked Compounds from Primary Screen [AID2810, Type: screening]integrin alpha-L [Mus musculus] [gi:124486680]
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32
[SID51088030]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit/block inward-rectifying potassium ion channel Kir2.1 [AID1672, Type: screening]inward rectifier potassium channel 2 [Mus musculus] [gi:6680530]
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33
[SID51088030]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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34
[SID51088030]
 Fluorescence polarization-based biochemical primary high throughput screening assay to identify activators of the Protein Kinase A-R1A (PKA-R1A) complex [AID504707, Type: screening]cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Mus musculus] [gi:6755076]
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35
[SID51088030]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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36
[SID51088030]
Potency qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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37
[SID51088030]
 Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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38
[SID51088030]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_SinglePoint_HTS_Activity [AID504775, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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39
[SID51088030]
 HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_SinglePoint_HTS_Activity [AID488896, Type: screening]Scarb1 gene product [Mus musculus] [gi:14389423]
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40
[SID51088030]
 Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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41
[SID51088030]
 Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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42
[SID51088030]
 Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). [AID2247, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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43
[SID51088030]
 High throughput screening of activators of transient receptor potential cation channel C6 (TRPC6) [AID2550, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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44
[SID51088030]
 High throughput screening of inhibitors of transient receptor potential cation channel C6 (TRPC6) [AID2553, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
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45
[SID51088030]
 uHTS fluorescent assay for identification of inhibitors of ATG4B [AID504462, Type: screening]cysteine protease ATG4B isoform a [Homo sapiens] [gi:47132611]
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46
[SID51088030]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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47
[SID51088030]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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48
[SID51088030]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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49
[SID51088030]
 Dyrk1 A HTS Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_SinglePoint_HTS_Activity [AID504441, Type: screening]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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50
[SID51088030]
Potency qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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