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acetovanillone (CID 2214) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(477)
 
 
Inconclusive(2)
 
 
Unspecified(13)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(15)
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
Troponin(4)
 
 
BioAssay Types:
Screening(345)
 
 
Confirmatory(110)
 
 
 
 
Literature(28)
 
 
 
 
BioActivity Types:
Potency(97)
 
 
 
 
IC50(14)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 451    Data Row: 493   Total Pages: 25   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103409349]
IC50 3.9Antioxidant activity in human neutrophils assessed as inhibition of oxidative burst-induced ROS production by chemiluminescence assay [AID1070497, Type: Literature]
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2
[SID103409349]
IC50 1090Inhibition of NADPH oxidase in human HUVEC assessed as inhibition of superoxide anion generation by cytochrome-C reduction assay [AID436595, Type: Literature]
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3
[SID103409349]
IC50 61000Inhibition of p47phox/p22phox interaction by ELISA [AID436598, Type: Literature]
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4
[SID51088030]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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5
[SID103409349]
Ability to protect microvascular damages in ischemia/reperfusion (in vivo) was determined by measuring the inhibition of leaky sites, 30-min after the start of reperfusion at 30 mg/kg [AID87266, Type: Literature]
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6
[SID103409349]
Inhibition of beta-hexosaminidase in anti-DNP IgE sensitized rat RBL2H3 cells at 100 uM after 10 mins [AID333180, Type: Literature]
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7
[SID103409349]
Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of TNFalpha formation at 30 uM pretreated 1 hr before LPS challenge measured after 24 hrs by enzyme immunoassay [AID360334, Type: Literature]
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8
[SID103409349]
Antiinflammatory activity in LPS/IFN-gamma-stimulated mouse N9 cells assessed as inhibition of TNFalpha formation at 30 uM pretreated 1 hr before LPS/IFNgamma challenge measured after 24 hrs by enzyme immunoassay [AID360336, Type: Literature]
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9
[SID103409349]
Antioxidant activity against microvascular damage in hamster model of cheek pouch submitted to ischemia/reperfusion assessed as inhibition of leaky sites at 3 mg/kg treated by gavage route 30 mins before anesthesia measured after 30 mins of reperfusion by FITC-dextran based microscopy [AID430015, Type: Literature]
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10
[SID103409349]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 30 uM after 72 hrs [AID462333, Type: Literature]
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11
[SID103409349]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 10 uM after 72 hrs [AID462334, Type: Literature]
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12
[SID103409349]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 3 uM after 72 hrs [AID462335, Type: Literature]
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13
[SID103409349]
Inhibition of theophylline-stimulated melanogenesis in mouse B16-4A5 cells at 1 uM after 72 hrs [AID462336, Type: Literature]
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14
[SID103409349]
Toxicity in mouse B16-4A5 cells assessed as inhibition of cell proliferation at 30 uM in presence of 1 mM theophylline after 72 hrs by WST8 dye reduction assay [AID462342, Type: Literature]
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15
[SID51088030]
Potency 2.5119qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
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16
[SID51088030]
Potency 25.929A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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17
[SID51088030]
Potency 89.1251HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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18
[SID51088030]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
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19
[SID51088030]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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20
[SID51088030]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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