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BioActivity Data for Compound Antipyrine (CID 2206)

BioActivity Outcomes:
Active(8)
 
 
Inactive(999)
 
 
Inconclusive(44)
 
 
Unspecified(463)
 
 
Top Targets:
7tm 4(59)
 
 
 
NR LBD PPAR(29)
 
 
 
p450(25)
 
 
 
NR LBD ER(25)
 
 
 
NR LBD AR(24)
 
 
 
 
BioAssay Types:
Confirmatory(642)
 
 
 
 
 
Screening(293)
 
 
 
Literature(231)
 
 
 
 
Summary(78)
 
 
 
BioAssay Categories:
In vitro(147)
 
 
 
In vivo(190)
 
 
 
Biochemical(226)
 
 
 
Toxicity(224)
 
 
 
 
ADME(104)
 
 
Cell-based(194)
 
 
 
 
Organism-base..(9)
 
 
 
BioActivity Types:
Potency(541)
 
 
 
 
 
IC50(124)
 
 
 
AC50(6)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1103    Data Row: 1514   Total Pages: 76   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56320742]
Potency 5.0119qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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2
[SID48414294]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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3
[SID48414294]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results [AID1205, Type: other]
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4
[SID48414294]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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5
[SID56320742]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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6
[SID56320742]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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7
[SID103188539]
Antipyretic activity against IL-1beta-induced hyperthermia in rat assessed as change in rectal temperature at 100 mg/kg, icv measured after 2 hrs [AID604519, Type: Literature]
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8
[SID103188539]
Antinociceptive activity in rat assessed as suppression of carrageenan-induced nociception in right hind paw at 100 mg/kg, po measured after 1 hr [AID604523, Type: Literature]
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9
[SID103188539]
Antigenicity in guinea pig assessed as erythema in abdomen at 1 mg/kg, id measured after 24 hrs by skin reaction assay [AID604524, Type: Literature]
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10
[SID103188539]
Metabolic stability in rat liver microsomes assessed as increase in D-methylation products after 20 mins by HPLC analysis [AID604525, Type: Literature]
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11
[SID103188539]
Metabolic stability in rat liver microsomes assessed as hydroxymethylpyrine formation per mg of protein after 20 mins by HPLC analysis [AID604578, Type: Literature]
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12
[SID103188539]
Metabolic stability in rat liver microsomes assessed as norantipyrine formation per mg of protein after 20 mins by HPLC analysis [AID604579, Type: Literature]
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13
[SID103188539]
Metabolic stability in rat liver microsomes assessed as hydroxyantipyrine formation per mg of protein after 20 mins by HPLC analysis [AID604580, Type: Literature]
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14
[SID103188539]
Drug excretion in rat urine assessed as hydroxymethylpyrine formation at 100 mg/kg, po measured after 24 hrs by HPLC analysis [AID604581, Type: Literature]
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15
[SID103188539]
Drug excretion in rat urine assessed as norantipyrine formation at 100 mg/kg, po measured after 24 hrs by HPLC analysis [AID604582, Type: Literature]
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16
[SID103188539]
Drug excretion in rat urine assessed as hydroxyantipyrine formation at 100 mg/kg, po measured after 24 hrs by HPLC analysis [AID604583, Type: Literature]
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17
[SID103188539]
Drug excretion in rat urine at 100 mg/kg, po measured after 24 hrs by HPLC analysis [AID604584, Type: Literature]
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18
[SID103188539]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: confirmatory]
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19
[SID103188539]
DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) [AID625265, Type: other]
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20
[SID103188539]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: confirmatory]
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