CHEMBL377346 (CID 22056040) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(7)
 
 
Top Targets:
Ig(2)
 
 
PTKc Abl(2)
 
 
PTKc FGFR1(1)
 
 
PTKc VEGFR(1)
 
 
BioAssay Types:
Literature(7)
 
 
BioActivity Types:
IC50(5)
 
 
EC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 7    Data Row: 7   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103492527]
IC50 0.003Inhibition of VEGFR1 [AID268026, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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2
[SID103492527]
IC50 0.003Inhibition of VEGFR1 [AID268026, Type: Literature]Vascular endothelial growth factor receptor 1 [gi:143811474]
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3
[SID103492527]
IC50 0.008Inhibition of FGFR1 [AID268028, Type: Literature]Fibroblast growth factor receptor 1 [gi:120046]
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4
[SID103492527]
IC50 0.008Inhibition of FGFR1 [AID268028, Type: Literature]Fibroblast growth factor receptor 1 [gi:120046]
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5
[SID103492527]
IC50 0.03Inhibition of VEGFR2 [AID268025, Type: Literature]Vascular endothelial growth factor receptor 2 [gi:549321]
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6
[SID103492527]
IC50 0.06Inhibition of c-ABL [AID266584, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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7
[SID103492527]
IC50 0.06Inhibition of c-ABL [AID266584, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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8
[SID103492527]
IC50 0.083Inhibition of PDGFRbeta [AID268027, Type: Literature]Platelet-derived growth factor receptor beta [gi:129891]
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9
[SID103492527]
EC50 0.19Inhibition of VEGF-mediated proliferation of HMVEC [AID268029, Type: Literature]
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10
[SID103492527]
EC50 0.97Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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11
[SID103492527]
EC50 0.97Antiproliferative activity against K562 cells expressing Bcr-Abl [AID266585, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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