anagrelide (CID 2182) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(19)
 
 
Inactive(47)
 
 
Inconclusive(3)
 
 
Unspecified(44)
 
 
Top Targets:
HDc(5)
 
 
 
NR LBD TR(2)
 
 
NR LBD ROR li..(2)
 
 
Menin(2)
 
 
 
HELICc(2)
 
 
BioAssay Types:
Literature(63)
 
 
 
Confirmatory(45)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(43)
 
 
 
EC50(10)
 
 
IC50(9)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 113    Data Row: 113   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103202719]
EC50 0.02In vitro inhibition of collagen-induced blood platelet aggregation [AID161781, Type: Literature]
View
2
[SID103202719]
EC50 0.02In vitro inhibition of blood platelet aggregation (collagen) in rats [AID175857, Type: Literature]
View
3
[SID103202719]
IC50 0.05Inhibition of hydrolysis of c-AMP phosphodiesterase in human platelets [AID219178, Type: Literature]cGMP-inhibited 3',5'-cyclic phosphodiesterase A [gi:47117888]
View
4
[SID103202719]
IC50 0.054Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis [AID158576, Type: Literature]
View
5
[SID103202719]
IC50 0.08In vitro inhibition of cyclic AMP phosphodiesterase from human platelets. [AID219853, Type: Literature]
View
6
[SID103202719]
IC50 0.08Inhibition of platelet cAMP phosphodiesterase [AID219979, Type: Literature]cGMP-inhibited 3',5'-cyclic phosphodiesterase A [gi:47117888]
View
7
[SID103202719]
IC50 0.082Inhibition of human blood platelet c-AMP phosphodiesterase [AID219175, Type: Literature]cGMP-inhibited 3',5'-cyclic phosphodiesterase A [gi:47117888]
View
8
[SID103202719]
EC50 0.27Inhibition of platelet aggregation induced by collagen in rabbit platelet rich plasma [AID225752, Type: Literature]
View
9
[SID103202719]
EC50 0.27Inhibition of platelet aggregation using collagen as activating agent in rabbit platelet rich plasma (PRP) [AID165602, Type: Literature]
View
10
[SID103202719]
EC50 0.8In vitro inhibition of ADP-induced blood platelet aggregation [AID161780, Type: Literature]
View
11
[SID103202719]
EC50 0.8In vitro inhibition of blood platelet aggregation (ADP) in rats [AID175856, Type: Literature]
View
12
[SID103202719]
IC50 1.05Inhibition of human platelet c-AMP phosphodiesterase PDE 3 [AID219160, Type: Literature]cGMP-inhibited 3',5'-cyclic phosphodiesterase A [gi:47117888]
View
13
[SID103202719]
EC50 1.05Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP) [AID165601, Type: Literature]
View
14
[SID103202719]
EC50 1.05Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) [AID92528, Type: Literature]
View
15
[SID103202719]
EC50 1.05Inhibition of adp-induced platelet aggregation in human platelet rich plasma. [AID225749, Type: Literature]
View
16
[SID103202719]
EC50 1.05Inhibition of platelet aggregation induced by ADP in rabbit platelet rich plasma [AID225751, Type: Literature]
View
17
[SID103202719]
IC50 2.6Inhibition of ADP-induced platelet aggregation [AID92096, Type: Literature]
View
18
[SID103202719]
IC50 34Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis [AID158577, Type: Literature]
View
19
[SID103202719]
IC50 34Inhibition of cGMP hydrolysis by human platelet phosphodiesterase [AID219326, Type: Literature]cGMP-dependent 3',5'-cyclic phosphodiesterase [gi:3182954]
View
20
[SID103202719]
 Inhibition of rat heart cAMP phosphodiesterase (weak partial inhibition) [AID219995, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:1705947]
View
21
[SID103202719]
 Compound was evaluated for the inhibition of ADP-induced aggregation of human platelets [AID92673, Type: Literature]
View
22
[SID103202719]
 Inhibition of coronary artery occlusion (mean area under flow time curve) in anesthetized dog at 0.03 mg/kg [AID61946, Type: Literature]
View
23
[SID103202719]
 Inhibition of thrombus formation (mean thrombus area) in conscious rabbits at 1.0 mg/kg [AID166514, Type: Literature]
View
24
[SID103202719]
 Inhibition of thrombus formation (mean thrombus area) in conscious rabbits at 10.0 mg/kg [AID166517, Type: Literature]
View
25
[SID103202719]
 Inhibition of thrombus formation (mean thrombus area) in conscious rabbits at 3.0 mg/kg [AID166519, Type: Literature]
View
26
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg (1h after dose) [AID174227, Type: Literature]
View
27
[SID103202719]
 Effect of compound on systolic blood pressure in rat after an oral dose at 50 mg/kg (24h after dose) [AID174229, Type: Literature]
View
28
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg (3h after dose) [AID174232, Type: Literature]
View
29
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg (4h after dose) [AID174233, Type: Literature]
View
30
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg (5h after dose) [AID174234, Type: Literature]
View
31
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg (6h after dose) [AID174235, Type: Literature]
View
32
[SID103202719]
 Ex vivo in vitro inhibition of blood platelet aggregation (ADP) in rats at oral dose 10 mg/kg 1 hour before the tes [AID183707, Type: Literature]
View
33
[SID103202719]
 Ex vivo inhibition of blood platelet aggregation (collagen) in rats at oral dose 10 mg/kg 1 hour before the test [AID183710, Type: Literature]
View
34
[SID103202719]
 Effect on heart rate in rat after an oral dose at 50 mg/kg [AID185811, Type: Literature]
View
35
[SID103202719]
 Effect on systolic blood pressure in rat after an oral dose at 50 mg/kg [AID193277, Type: Literature]
View
36
[SID103202719]
 Ex vivo inhibition of ADP-induced blood platelet aggregation in rat was measured 2 hr after administration of vehical alone [AID193720, Type: Literature]
View
37
[SID103202719]
 Ex vivo inhibition of ADP-induced blood platelet aggregation in rat was measured 2 hr after administration of vehical alone (delta A/min *10e 3) [AID193721, Type: Literature]
View
38
[SID103202719]
 Ex vivo inhibition of collagen-induced blood platelet aggregation in rat was measured 2 hr after administration of vehical alone [AID193723, Type: Literature]
View
39
[SID103202719]
 Ex vivo inhibition of collagen-induced blood platelet aggregation in rat was measured 2 hr after oral administration of 50 mg/kg [AID193724, Type: Literature]
View
40
[SID103202719]
 Effect on heart rate in rat after an oral dose at 50 mg/kg (1h after dose) [AID194033, Type: Literature]
View
41
[SID103202719]
 Effect on heart rate in rat after an oral dose at 50 mg/kg (3h after dose) [AID194038, Type: Literature]
View
42
[SID103202719]
 Effect on heart rate in rat after an oral dose at 50 mg/kg (4h after dose) [AID194039, Type: Literature]
View
43
[SID103202719]
 Effect of compound on heart rate in rat after an oral dose at 50 mg/kg (5h after dose) [AID194040, Type: Literature]
View
44
[SID103202719]
 Effect of compound on heart rate in rat after an oral dose at 50 mg/kg (6h after dose) [AID194042, Type: Literature]
View
45
[SID103202719]
 Inhibition of coronary artery occlusion (mean area under flow time curve) in anesthetized dog at 0.1 mg/kg [AID61947, Type: Literature]
View
46
[SID103202719]
 Inhibition of coronary artery occlusion (mean area under flow time curve) in anesthetized dog at 0.3 mg/kg [AID61948, Type: Literature]
View
47
[SID103202719]
 Ex vivo inhibition of rat platelet aggregation induced by ADP. [AID225747, Type: Literature]
View
48
[SID103202719]
 Octanol-water partition coefficient, log P of the compound [AID477295, Type: Literature]
View
49
[SID103202719]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cholelithiasis [AID625281, Type: Literature]
View
50
[SID103202719]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for cirrhosis [AID625282, Type: Literature]
View