O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate (CID 21804) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(13)
 
 
Inactive(25)
 
 
Inconclusive(17)
 
 
Unspecified(13)
 
 
Top Targets:
7TM GPCR Srsx(5)
 
 
 
NR LBD PPAR(5)
 
 
 
NR LBD TR(4)
 
 
 
NR LBD VDR(2)
 
 
 
NR LBD RXR li..(2)
 
 
BioAssay Types:
Literature(33)
 
 
 
 
 
Confirmatory(26)
 
 
 
BioActivity Types:
Potency(26)
 
 
 
IC50(8)
 
 
Kd(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 60    Data Row: 68   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103590572]
Kd 0.00086Displacement of [3H]CP-55940 from CB1 receptor in mouse brain at 100 nM [AID409807, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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2
[SID103590572]
IC50 0.003Displacement of [3H]CP-55940 from mouse CB1 receptor expressed in HEK293 cells [AID409805, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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3
[SID103590572]
IC50 0.01Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
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4
[SID103590572]
IC50 0.01Displacement of 2-arachidonylglycerol from MAGL in Swiss Webster mouse brain after 5 mins [AID503381, Type: Literature]Monoglyceride lipase [gi:47117040]
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5
[SID103590572]
IC50 0.01Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
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6
[SID103590572]
IC50 0.01Inhibition of MAGL-mediated 2-arachidonoylglycerol hydrolysis in mouse brain [AID409757, Type: Literature]Monoglyceride lipase [gi:47117040]
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7
[SID103590572]
IC50 0.01Displacement of [3H]CP-55940 from CB1 receptor in mouse brain [AID409760, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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8
[SID103590572]
IC50 0.04Inhibition of FAAH-mediated [3H]anadamide hydrolysis in mouse brain [AID409759, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
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9
[SID103590572]
IC50 0.063Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
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10
[SID103590572]
IC50 0.063Displacement of acetylcholine from AChE in Swiss Webster mouse brain after 5 mins [AID503579, Type: Literature]Acetylcholinesterase [gi:113038]
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11
[SID103590572]
IC50 0.46Displacement of [3H]anandamide from FAAH in Swiss Webster mouse brain after 5 mins [AID503576, Type: Literature]Fatty-acid amide hydrolase 1 [gi:6225311]
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12
[SID103590572]
IC50 25Displacement of [3H]CP-55940 from mouse CB1 receptor expressed in HEK293 cells in presence of mouse brain membrane [AID409808, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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13
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated cataleptic behavior in KIAA1363-deficient Swiss Webster mouse at 100 mg/kg, ip [AID503588, Type: Literature]
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14
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypomobility in Swiss Webster mouse at 2 mg/kg, ip [AID503583, Type: Literature]
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15
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypomobility in Swiss Webster mouse at 3 mg/kg, ip [AID503584, Type: Literature]
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16
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypothermia in Swiss Webster mouse at 4 mg/kg, ip [AID503586, Type: Literature]
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17
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as unsaturated C24:1 fatty acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503534, Type: Literature]
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18
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as saturated C18:0 fatty acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503572, Type: Literature]
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19
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as anandamide level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503400, Type: Literature]
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20
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as 2-arachidonylglycerol level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503401, Type: Literature]
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21
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as aracidonic acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503402, Type: Literature]
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22
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as N-palmitoyl-ethanolamine level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503403, Type: Literature]
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23
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as unsaturated N-oleoyl-ethanolamine level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503404, Type: Literature]
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24
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as saturated C20:0 fatty acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503406, Type: Literature]
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25
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as unsaturated C20:4 fatty acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503407, Type: Literature]
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26
[SID103590572]
 Disruption of endocannabinoid metabolism in Swiss Webster mouse brain assessed as saturated C22:0 fatty acid level per gram of tissue at 4 mg/kg, ip after 4 hrs [AID503408, Type: Literature]
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27
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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28
[SID103590572]
 Inhibition of 2-arachidonylglycerol hydrolysis in Swiss Webster mouse brain at 4 mg/kg, ip after 4 hrs [AID503577, Type: Literature]
View
29
[SID103590572]
 Inhibition of anandamide hydrolysis in Swiss Webster mouse brain at 4 mg/kg, ip after 4 hrs [AID503578, Type: Literature]
View
30
[SID26757094]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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31
[SID26757094]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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32
[SID26757094]
Potency qHTS assay for environmental chemicals that activate the Aryl hydrocarbon Receptor (AhR) signaling pathway [AID651777, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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33
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_1, Type: other]
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34
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_2, Type: other]
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35
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_3, Type: other]
View
36
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_4, Type: other]
View
37
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_5, Type: other]
View
38
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_6, Type: other]
View
39
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_7, Type: other]
View
40
[SID26757094]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838_8, Type: other]
View
41
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypomobility in Swiss Webster mouse at 3 mg/kg, ip in presence of 10 mg/kg, ip CB1 receptor antagonist AM251 [AID503580, Type: Literature]
View
42
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypomobility in Swiss Webster mouse at 2 mg/kg, ip in presence of 10 mg/kg, ip CB1 receptor antagonist AM251 [AID503582, Type: Literature]
View
43
[SID103590572]
 Effect on CB1-dependent cannabinoid-mediated hypothermia in Swiss Webster mouse at 4 mg/kg, ip in presence of 10 mg/kg, ip CB1 receptor antagonist AM251 [AID503587, Type: Literature]
View
44
[SID26757094]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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45
[SID26757094]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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46
[SID26757094]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
47
[SID26757094]
Potency qHTS assay for small molecule agonists of glucocorticoid receptor signaling [AID588532, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
View
48
[SID26757094]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
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49
[SID26757094]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
View
50
[SID26757094]
Potency qHTS assay for small molecule activators of the nuclear factor-kappa B (NF-kB) signaling pathway [AID651749, Type: confirmatory]NFKB1 gene product [Homo sapiens] [gi:34577122]
View