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Amsacrine (CID 2179) - Compound BioActivity Data
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BioActivity Outcomes:
Active(256)
 
 
Inactive(134)
 
 
Inconclusive(52)
 
 
Unspecified(231)
 
 
Top Targets:
p450(15)
 
 
 
 
TOP4c(9)
 
 
 
7TM GPCR Srx(6)
 
 
 
 
Pyruvate Kina..(4)
 
 
HSD10-like SD..(4)
 
 
BioAssay Types:
Literature(390)
 
 
 
 
 
Confirmatory(210)
 
 
 
 
BioActivity Types:
IC50(127)
 
 
 
 
Potency(115)
 
 
 
 
EC50(11)
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 656    Data Row: 673   Total Pages: 14   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166066]
IC50 0.0006Inhibitory activity of compound for AA8 cells to reduce cell density by 50% (exposed to compound for 4 hours) [AID45745, Type: Literature]
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2
[SID103166066]
IC50 0.004The compound was tested for the cytotoxicity DC-3F cell lines [AID53603, Type: Literature]
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3
[SID103166066]
IC50 0.0051Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue test [AID317175, Type: Literature]
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4
[SID103166066]
IC50 0.006Growth inhibition in human HL60 cells after 72 hrs by trypan blue assay [AID576613, Type: Literature]
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5
[SID103166066]
IC50 0.012Growth inhibition in human HeLa cells after 72 hrs by trypan blue assay [AID576615, Type: Literature]
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6
[SID103166066]
IC50 0.012Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue test [AID317174, Type: Literature]
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7
[SID103166066]
IC50 0.012In vitro cell growth inhibitory activity against wild type P388 murine leukemia cell line (P388/W) [AID150522, Type: Literature]
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8
[SID103166066]
IC50 0.012Inhibitory activity against Lewis lung carcinoma cells [AID100108, Type: Literature]
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9
[SID103166066]
IC50 0.012Inhibitory concentration against Murine Lewis lung carcinoma (LLC) cell proliferation [AID100239, Type: Literature]
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10
[SID103166066]
IC50 0.012Inhibitory concentration required to reduce Lewis lung carcinoma cell number to 50% of control cultures [AID100240, Type: Literature]
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11
[SID103166066]
IC50 0.012Inhibitory activity of tested against Murine Lewis lung carcinoma [AID103106, Type: Literature]
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12
[SID103166066]
IC50 0.02Inhibitory activity against P388 murine leukemia cells [AID150659, Type: Literature]
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13
[SID103166066]
IC50 0.02Inhibitory activity against Murine p38 leukemia [AID150664, Type: Literature]
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14
[SID103166066]
IC50 0.02Inhibitory concentration to reduce cell number to 50% of Murine P388 leukemia cell culture [AID150670, Type: Literature]
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15
[SID103166066]
IC50 0.02Inhibitory concentration required to reduce murine p388 leukemia cell number to 50% of control cultures [AID150673, Type: Literature]
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16
[SID103166066]
IC50 0.02Cytotoxicity against human Jurkat cells by Hoechst test [AID365818, Type: Literature]
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17
[SID103166066]
IC50 0.021In vitro cytotoxicity against human leukemic HL-60 cell line. [AID81631, Type: Literature]
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18
[SID103166066]
IC50 0.023Cytotoxicity against human K562 cells after 5 days by XTT assay [AID312292, Type: Literature]
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19
[SID103166066]
ID50 0.03Concentration for inhibiting the growth of P-388 cells by 50% over 3 days was determined [AID150694, Type: Literature]
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20
[SID103166066]
IC50 0.03Inhibitory activity against A549 cell line using MTT assay(Wild type p53) [AID8681, Type: Literature]
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21
[SID103166066]
IC50 0.033In vitro for cytotoxicity against murine leukemia cells (L1210) [AID98133, Type: Literature]
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22
[SID103166066]
IC50 0.033In vitro inhibitory activity against Murine leukemia (L1210) [AID98378, Type: Literature]
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23
[SID103166066]
ID50 0.035Reduce in the cell count when drug added to the murine L1210 leukemia cell cultures for 70 h [AID98699, Type: Literature]
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24
[SID103166066]
ID50 0.035Growth inhibition against cultured murine L1210 leukemia cells [AID98700, Type: Literature]
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25
[SID103166066]
ID50 0.035In vitro concentration required to inhibit the growth of L1210 cells in culture by 50% following a 48 hr exposure. [AID101091, Type: Literature]
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26
[SID103166066]
ID50 0.035In vitro test for 50% reduction of cell number (of control) after 70 hr incubation with cultures of murine L1210 leukemia cells [AID96632, Type: Literature]
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27
[SID103166066]
ID50 0.035Concentration for inhibiting the growth of L1210 cells by 50% over 3 days was determined [AID96646, Type: Literature]
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28
[SID103166066]
ID50 0.035In vitro concentration required to reduce the murine L1210 leukemia cells in cultures to 50% after a period of 72 hr. [AID96799, Type: Literature]
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29
[SID103166066]
IC50 0.037Inhibitory activity against Jurkat human leukemia cells [AID91915, Type: Literature]
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30
[SID103166066]
IC50 0.037Inhibitory concentration against Human Jurkat leukemia (JLC) cell proliferation [AID91916, Type: Literature]
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31
[SID103166066]
IC50 0.037Inhibitory concentration required to reduce human Jurkat leukemia (JLC sensitive, wild type) cell number to 50% of control cultures [AID91917, Type: Literature]
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32
[SID103166066]
IC50 0.037Concentration required to inhibit 50% growth of human Jurkat cells [AID95291, Type: Literature]
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33
[SID103166066]
IC50 0.04Inhibitory activity against F460pv8/eto cell line using MTT assay [AID68776, Type: Literature]
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34
[SID103166066]
IC50 0.04Cytotoxicity against mouse B16F0 cells by Hoechst test [AID365816, Type: Literature]
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35
[SID103166066]
IC50 0.047The compound was tested for the cytotoxicity against human leukemic DC-3F/ADII cell lines, activity is expressed as IC50 values. [AID53621, Type: Literature]
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36
[SID103166066]
IC50 0.05Inhibitory concentration against L1210 leukemic cell proliferation over 24 hr [AID96566, Type: Literature]
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37
[SID103166066]
IC50 0.06Inhibitory activity against NCI-H460 cell line using MTT assay [AID143042, Type: Literature]
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38
[SID103166066]
IC50 0.06Inhibitory activity against NCI-H460 cell line using MTT assay(Wild type p53) [AID143043, Type: Literature]
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39
[SID103166066]
IC50 0.06Inhibitory activity against SKBR-3 cell line using MTT assay (ER-amplified erB2,mutant p53) [AID202679, Type: Literature]
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40
[SID103166066]
IC50 0.07Inhibitory activity against NCI-H647 cell line using MTT assay(mutant p53) [AID143360, Type: Literature]
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41
[SID103166066]
IC50 0.075Inhibitory activity against MCF7wt cell line using MTT assay [AID103274, Type: Literature]
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42
[SID103166066]
IC50 0.075Inhibitory activity against MCF-7 wt cell line using MTT assay (ER+,pgR+,wildtype p53) [AID103073, Type: Literature]
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43
[SID103166066]
IC50 0.08Cytotoxicity against human DLD1 cells by Hoechst test [AID365817, Type: Literature]
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44
[SID103166066]
IC50 0.08Cytotoxicity against human Jurkat cells by resazurin reduction test [AID365813, Type: Literature]
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45
[SID103166066]
IC50 0.08Cytotoxicity against mouse B16F0 cells by resazurin reduction test [AID365814, Type: Literature]
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46
[SID103166066]
IC50 0.08Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay [AID665993, Type: Literature]
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47
[SID103166066]
IC50 0.1Concentration required to inhibit the cell growth by 50 % after 96 hr A2780 leukemic cells. [AID10004, Type: Literature]
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48
[SID103166066]
IC50 0.12In vitro for the inhibition of human colon tumor (HCT-8) cells. [AID78828, Type: Literature]
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49
[SID103166066]
IC50 0.12In vitro for cytotoxicity against human colon tumor cells (HCT-8) in culture [AID78992, Type: Literature]
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50
[SID103166066]
IC50 0.13Cytotoxicity against human CCRF-CEM cells after 72 hrs [AID382900, Type: Literature]
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