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5,8-Quinolinedione, 7-amino-2-(2-pyridinyl)- (CID 21771691) - Compound BioActivity Data
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BioActivity Outcomes:
Active(13)
 
 
Inactive(5)
 
 
Unspecified(14)
 
 
Top Targets:
PAD(5)
 
 
PAD M(4)
 
 
Flavodoxin 2(1)
 
 
BioAssay Types:
Literature(16)
 
 
 
Confirmatory(5)
 
 
BioActivity Types:
IC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 21    Data Row: 32   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118043663]
Average IC50 [PAD3] 0.13Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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2
[SID118043663]
Average IC50 [PAD2] 0.32Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471_2, Type: confirmatory]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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3
[SID118043663]
Average IC50 [PAD4] 0.64Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471_4, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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4
[SID118043663]
Average IC50 [PAD1] 0.95Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471_1, Type: confirmatory]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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5
[SID103245835]
IC50 5.3Cytotoxicity against human MDA-MB-468 cells expressing NQO1 incubated for 2 hrs measured after 3 to 5 days by MTT assay [AID737919, Type: Literature]
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6
[SID103245835]
IC50 19Cytotoxicity against NQO1-deficient human wild type MDA-MB-468 cells incubated for 2 hrs measured after 3 to 5 days by MTT assay [AID737921, Type: Literature]
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7
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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8
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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9
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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10
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 3 against PAD1-4 [AID588471, Type: confirmatory]
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11
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
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12
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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13
[SID118043663]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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14
[SID103245835]
Cytotoxic activity against mouse melanoma cell culture(B-16) [AID38038, Type: Literature]
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15
[SID103245835]
Cytotoxic activity against human lymphoblastic leukemia cell culture (CCRF-CEM) [AID44017, Type: Literature]
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16
[SID103245835]
Antimicrobial activity was determined against Candida albicans ATCC 10231 [AID44988, Type: Literature]
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17
[SID103245835]
Antimicrobial activity was determined against Escherichia coli ATCC 9637 [AID69959, Type: Literature]
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18
[SID103245835]
Cytotoxic activity against human epidermoid carcinoma of the nasopharynx (9KB) [AID70059, Type: Literature]
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19
[SID103245835]
Antimicrobial activity was determined against Klebsiella pneumoniae ATCC 10031 [AID94298, Type: Literature]
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20
[SID103245835]
Drug metabolism assessed as human recombinant NQO1-mediated cytochrome C reduction per mg of protein by spectrophotometric analysis [AID737923, Type: Literature]NAD(P)H dehydrogenase [quinone] 1 [gi:118607]
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