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amlexanox (CID 2161) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(33)
 
 
Inactive(450)
 
 
Inconclusive(63)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(14)
 
 
 
7TM GPCR Srx(11)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
BioAssay Types:
Screening(232)
 
 
 
 
Confirmatory(207)
 
 
 
 
Literature(74)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(174)
 
 
 
 
IC50(37)
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 447    Data Row: 557   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26719859]
Potency 0.3162qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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2
[SID50112726]
Potency 0.4053Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID26719859]
Potency 0.4256qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID26719859]
Potency 0.5012qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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5
[SID144206029]
Potency-Replicate_1 0.8413qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID144206029]
AhR Potency (uM) 1.67855qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID50112726]
Potency 3.9811VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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8
[SID144206029]
Potency-Replicate_1 4.7308qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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9
[SID144206029]
ATAD5 Potency (uM) 5.5157qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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10
[SID26719859]
Potency 7.0795qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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11
[SID50112726]
Potency 7.9433qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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12
[SID26719859]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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13
[SID144206029]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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14
[SID26719859]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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15
[SID170465365]
Ratio Potency (uM) 18.1231qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID144206029]
Potency-Replicate_1 26.6032qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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17
[SID26719859]
Potency 35.4813qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID2242, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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18
[SID49681589]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 7 (SENP7) [AID434973, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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19
[SID49681589]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488917, Type: screening]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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20
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: other]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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21
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: other]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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22
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: other]cAMP-specific 3',5'-cyclic phosphodiesterase 4D [gi:12644392]
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23
[SID49681589]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488912, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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24
[SID49681589]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay [AID488919, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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25
[SID49681589]
HTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 8 (SENP8) [AID2540, Type: screening]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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26
[SID26719859]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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27
[SID48415555]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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28
[SID50112726]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749_11, Type: Literature]
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29
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: other]cAMP-specific 3',5'-cyclic phosphodiesterase 4B [gi:729163]
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30
[SID49681589]
uHTS Luminescent assay for identification of inhibitors of Sentrin-specific protease 6 (SENP6) [AID2599, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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31
[SID49681589]
Single concentration confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay [AID488915, Type: screening]SUMO-1-specific protease [Homo sapiens] [gi:6166485]
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32
[SID26719859]
uHTS for the identification of compounds that potentiate TRAIL-induced apoptosis of cancer cells [AID1443, Type: screening]tumor necrosis factor ligand superfamily member 10 isoform 1 [Homo sapiens] [gi:4507593]
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33
[SID49681589]
Single concentration confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay [AID488918, Type: screening]caspase-3 preproprotein [Homo sapiens] [gi:14790119]
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34
[SID103303757]
Compound was evaluated for anti passive cutaneous anaphylaxis activity in fasted rats administered oral route [AID182623, Type: Literature]
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35
[SID103303757]
Compound was evaluated for anti passive cutaneous anaphylaxis activity in nonfasted rats administered oral route [AID182625, Type: Literature]
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36
[SID103303757]
Anti-passive cutaneous anaphylaxis activity in rat (intravenous administration) [AID182626, Type: Literature]
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37
[SID103303757]
Anticonvulsant activity [AID227700, Type: Literature]
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38
[SID50112726]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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39
[SID103303757]
FDA HLAED, liver enzyme composite activity [AID588214, Type: Literature]
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40
[SID103303757]
FDA HLAED, alkaline phosphatase increase [AID588215, Type: Literature]
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41
[SID103303757]
FDA HLAED, serum glutamic oxaloacetic transaminase (SGOT) increase [AID588216, Type: Literature]
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42
[SID103303757]
FDA HLAED, serum glutamic pyruvic transaminase (SGPT) increase [AID588217, Type: Literature]
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43
[SID103303757]
FDA HLAED, lactate dehydrogenase (LDH) increase [AID588218, Type: Literature]
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44
[SID103303757]
FDA HLAED, gamma-glutamyl transferase (GGT) increase [AID588219, Type: Literature]
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45
[SID124893315]
Potency 0.0376qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
View
46
[SID26719859]
Potency 0.2612qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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47
[SID144206029]
Potency-Replicate_1 0.8413qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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48
[SID144206029]
Potency-Replicate_1 3.3491qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
View
49
[SID26719859]
Potency 7.0795qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
View
50
[SID124893315]
Potency 7.4929qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation [AID743344, Type: confirmatory]
View