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amlexanox (CID 2161) - Compound BioActivity Data
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BioActivity Outcomes:
Active(37)
 
 
Inactive(461)
 
 
Inconclusive(53)
 
 
Unspecified(11)
 
 
Top Targets:
NR LBD PPAR(14)
 
 
 
7TM GPCR Srx(11)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
HDc(8)
 
 
BioAssay Types:
Screening(232)
 
 
 
 
Confirmatory(208)
 
 
 
 
Literature(82)
 
 
 
 
 
Summary(24)
 
 
 
 
BioActivity Types:
Potency(175)
 
 
 
 
IC50(37)
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 448    Data Row: 562   Total Pages: 29   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26719859]
Potency 0.3162qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]Niemann-Pick C1 protein precursor [Homo sapiens] [gi:255652944]
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2
[SID50112726]
Potency 0.4053Biochemical firefly luciferase enzyme assay for NPC [AID624030, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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3
[SID26719859]
Potency 0.4256qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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4
[SID26719859]
Potency 0.5012qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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5
[SID144206029]
Potency-Replicate_1 0.8413qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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6
[SID144206029]
AhR Potency (uM) 1.67855qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway: Summary [AID743122, Type: summary]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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7
[SID50112726]
Potency 3.9811VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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8
[SID144206029]
Potency-Replicate_1 4.7308qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 [AID651632, Type: confirmatory]ATPase family AAA domain-containing protein 5 [gi:296439460]
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9
[SID144206029]
ATAD5 Potency (uM) 5.5157qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5: Summary [AID720516, Type: summary]ATPase family AAA domain-containing protein 5 [gi:296439460]
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10
[SID26719859]
Potency 7.0795qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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11
[SID50112726]
Potency 7.9433qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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12
[SID26719859]
Potency 10qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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13
[SID144206029]
Potency-Replicate_1 11.8832qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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14
[SID26719859]
Potency 14.1254qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase [AID1634, Type: confirmatory]pyruvate kinase PKM isoform a [Homo sapiens] [gi:33286418]
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15
[SID170465365]
Ratio Potency (uM) 18.1231qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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16
[SID170465365]
Potency-Replicate_1 23.7083qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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17
[SID26719859]
Potency 35.4813qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease [AID2242, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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18
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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19
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4C [gi:20141263]
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20
[SID103303757]
Phosphodiesterase 4 inhibitor [AID742467, Type: Literature]cAMP-specific 3',5'-cyclic phosphodiesterase 4A [gi:116242706]
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