2-[(2-bromobenzyl)oxy]benzoic acid (CID 2160985) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Probe(1)
 
 
Active(13)
 
 
Inactive(583)
 
 
Inconclusive(3)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
7TM GPCR Srsx(8)
 
 
NR LBD PPAR(6)
 
 
BioAssay Types:
Screening(397)
 
 
 
 
 
Confirmatory(187)
 
 
 
 
 
Literature(5)
 
 
Summary(1)
 
 
BioActivity Types:
Potency(122)
 
 
 
 
IC50(35)
 
 
EC50(26)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 597    Data Row: 606   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID57578338]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
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2
[SID57578338]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
View
3
[SID57578338]
 Project utilizing multiplex HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases [AID1772, Type: summary]ras protein [Homo sapiens] [gi:190938]
View
4
[SID57578338]
EC50 0.103Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID1334, Type: confirmatory]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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5
[SID57578338]
EC50 0.109Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
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6
[SID57578338]
EC50 0.109Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
7
[SID57578338]
EC50 0.109Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID1335, Type: confirmatory]ras protein [Homo sapiens] [gi:190938]
View
8
[SID57578338]
EC50 0.151Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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9
[SID57578338]
EC50 0.151Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID1340, Type: confirmatory]Rac1 protein [Homo sapiens] [gi:8574038]
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10
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
View
11
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
View
12
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype [AID759, Type: screening]ras protein [Homo sapiens] [gi:190938]
View
13
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
14
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype [AID757, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
15
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
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16
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac activated mutant [AID764, Type: screening]Rac1 protein [Homo sapiens] [gi:8574038]
View
17
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype [AID760, Type: screening]Ras-related protein Rab-2 [gi:46577642]
View
18
[SID24838021]
 Primary biochemical high throughput screening assay to identify inhibitors of VIM-2 metallo-beta-lactamase [AID1527, Type: screening]metallo beta-lactamase [Pseudomonas aeruginosa] [gi:7381449]
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19
[SID24838021]
 Early assessment of compound solubility in 1x PBS - Set 2 [AID624321, Type: other]
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20
[SID24838021]
 Early assessment of compound solubility in aqueous buffer - Set 2 [AID624323, Type: other]
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21
[SID24838021]
 Parallel artificial membrane permeability assay at pH 7.4 [AID624339, Type: other]
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22
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype [AID758, Type: screening]GTP-binding protein (rab7) [Canis lupus familiaris] [gi:164058]
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23
[SID24838021]
 HTS to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Cdc42 wildtype [AID761, Type: screening]cell division cycle 42 (GTP binding protein, 25kDa) [Homo sapiens] [gi:56202836]
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24
[SID24838021]
 Plasma Stability Mouse - Set 2 [AID624419, Type: other]
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25
[SID24838021]
 Plasma Stability Human - 2 [AID624420, Type: other]
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26
[SID24838021]
 Mouse hepatic microsome stability - Set 2 [AID624451, Type: screening]
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27
[SID24838021]
 Human hepatic microsome stability-Set 2 [AID624452, Type: screening]
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28
[SID24838021]
 Early assessment of compound stability in 1x PBS - Set 2 [AID624456, Type: other]
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29
[SID24838021]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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30
[SID24838021]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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31
[SID24838021]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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32
[SID24838021]
Potency 44.6684qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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33
[SID24838021]
Potency 44.6684qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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34
[SID24838021]
 uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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35
[SID24838021]
 uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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36
[SID24838021]
 uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase [AID2524, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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37
[SID24838021]
 uHTS Luminescent assay for identification of activators of human intestinal alkaline phosphatase [AID2524, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
View
38
[SID24838021]
 uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assay [AID1012, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
39
[SID24838021]
 uHTS identification of TNAP inhibitors in the absence of phosphate acceptor performed in luminescent assay [AID1012, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
40
[SID24838021]
EC50 uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay [AID1001, Type: confirmatory]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
41
[SID24838021]
EC50 uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay [AID1001, Type: confirmatory]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
42
[SID24838021]
 uHTS identification of compounds inhibiting TNAP at a high concentration of phosphate acceptor detected in a luminescent assay [AID1135, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
43
[SID24838021]
 uHTS identification of compounds inhibiting TNAP at a high concentration of phosphate acceptor detected in a luminescent assay [AID1135, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
44
[SID24838021]
 uHTS identification of compounds activating TNAP at a high concentration of phosphate acceptor detected in a luminescent assay [AID1136, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
45
[SID24838021]
 uHTS identification of compounds activating TNAP at a high concentration of phosphate acceptor detected in a luminescent assay [AID1136, Type: screening]alkaline phosphatase, tissue-nonspecific isozyme isoform 1 precursor [Homo sapiens] [gi:116734717]
View
46
[SID24838021]
 uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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47
[SID24838021]
 uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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48
[SID24838021]
IC50 Chemical Antagonists IAP-family anti-apoptotic proteins [AID1018, Type: confirmatory]X-linked inhibitor of apoptosis [Homo sapiens] [gi:8744934]
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49
[SID24838021]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
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50
[SID24838021]
 Primary screen for compounds that activate Alzheimer's amyloid precursor [AID1276, Type: screening]amyloid precursor protein; APP [Homo sapiens] [gi:257380]
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