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Ampyrone (CID 2151) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(721)
 
 
Inconclusive(33)
 
 
Unspecified(14)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
7TM GPCR Srsx(16)
 
 
p450(13)
 
 
PLDc mTdp1 2(8)
 
 
NR LBD PPAR(8)
 
 
BioAssay Types:
Confirmatory(337)
 
 
 
 
Screening(325)
 
 
Summary(24)
 
 
Literature(18)
 
 
 
 
BioActivity Types:
Potency(314)
 
 
 
 
IC50(14)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 637    Data Row: 769   Total Pages: 39   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103764925]
Antioxidant activity assessed as hydroxyl radical scavenging activity at 10 mM at pH 7 by fenton reaction [AID486711, Type: Literature]
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2
[SID103764925]
IC50 1000Inhibition of COX-1 in C57BL/6 mouse brain homogenate [AID636251, Type: Literature]Prostaglandin G/H synthase 1 [gi:129900]
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3
[SID103764925]
IC50 1000Inhibition of COX-2 in C57BL/6 mouse brain homogenate [AID636252, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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4
[SID8149589]
Screen for compounds that correct neuronal dysfunction without cell death as induced by the expression of polyglutamine-expanded, N-terminal huntingtin in C. elegans mechanosensory neurons (HDELENEU) [AID1599, Type: other]
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5
[SID56463364]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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6
[SID8149589]
Screen for compounds that increase glutamate transport activity in MN-1 cell line (GluUPTAKE) [AID1612, Type: other]
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7
[SID8149589]
Screen for compounds that inhibit protein aggregation formed by mutant SOD1 (GFPSOD1) [AID1613, Type: other]
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8
[SID8149589]
Screen for compounds that reduce polyglutamine (polyQ) inclusions in nerve growth factor (NGF)-treated PC12 cells (GFPQ80) [AID1614, Type: other]
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9
[SID8149589]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubH) [AID1616, Type: other]
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10
[SID11112217]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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11
[SID8149589]
Assay to identify inhibitors of polyglutamine-induced caspase-3 activation (CASP3) [AID1583, Type: other]
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12
[SID8149589]
Yeast cell-based screen for compounds that suppress polyglutamine aggregation in vivo (75Q-TubU) [AID1593, Type: other]
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13
[SID8149589]
Screen for compounds that selectively inhibit cytochrome c release from purified mitochondria (CytoCRel) [AID1603, Type: other]
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14
[SID8149589]
Screen for compounds that inhibit polyglutamine induced protein aggregation (AGREG) [AID1604, Type: other]
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15
[SID8149589]
Screening of compounds showing protective effect against cell death induced by familial amyotrophic lateral sclerosis (FALS)-linked mutantsuperoxide dismutase 1 (SOD1) (ALSOD1) [AID1605, Type: other]
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16
[SID26748316]
Potency 1.4125qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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17
[SID144206903]
Potency 2.5119qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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18
[SID56463364]
Potency 25.1189A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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19
[SID56463364]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1). [AID2130, Type: screening]protein phosphatase methylesterase 1 isoform a [Homo sapiens] [gi:7706645]
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20
[SID56463364]
Potency qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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