p-Aminohippuric Acid (CID 2148) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(8)
 
 
Inactive(609)
 
 
Inconclusive(41)
 
 
Unspecified(96)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
p450(12)
 
 
 
7TM GPCR Srsx(6)
 
 
MFS(6)
 
 
 
HELICc(5)
 
 
BioAssay Types:
Screening(273)
 
 
 
Confirmatory(249)
 
 
 
 
 
Literature(98)
 
 
 
 
 
BioActivity Types:
Potency(211)
 
 
 
 
 
IC50(15)
 
 
 
Ki(8)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 606    Data Row: 754   Total Pages: 16   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167358]
Ki 6.02Inhibition of human Oat1 expressed in Drosophila S2 cells [AID598877, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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2
[SID56463545]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID103167358]
Ki 9.33254Inhibition of mouse Oat1-mediated [3H]PAH uptake in Xenopus oocytes after 1 hr [AID360150, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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4
[SID56463545]
Potency 11.6891Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID26748682]
Potency 31.6228qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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6
[SID26748682]
Potency 31.6228qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID56463545]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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8
[SID48415550]
 DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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9
[SID11112164]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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10
[SID11112164]
 qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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11
[SID103167358]
Km 3.9TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679375, Type: other]
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12
[SID103167358]
Km 4TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678820, Type: other]
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13
[SID103167358]
Km 5TP_TRANSPORTER: uptake in OAT1-expressing HeLa cells [AID679321, Type: other]
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14
[SID103167358]
Ki 6.02TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT1-expressing S2 cells [AID678821, Type: other]
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15
[SID103167358]
Km 8.5TP_TRANSPORTER: uptake in OAT1-MDCK cells [AID682074, Type: other]
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16
[SID103167358]
IC50 8.8TP_TRANSPORTER: inhibition of 6-Carboxyfluorescein uptake in OAT1-expressing CHO cells [AID681331, Type: other]
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17
[SID103167358]
Km 8.9TP_TRANSPORTER: uptake in OAT1-COS7 cells [AID679383, Type: other]
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18
[SID103167358]
Km 9.3TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679372, Type: other]
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19
[SID103167358]
Km 14.3TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681362, Type: other]
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20
[SID103167358]
Km 15.4TP_TRANSPORTER: uptake in OAT1-expressing CHO cells [AID679323, Type: other]
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21
[SID103167358]
Ki 19.6TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells [AID678814, Type: other]
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22
[SID103167358]
Km 22TP_TRANSPORTER: uptake in OAT1-expressing OK cells [AID679380, Type: other]
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23
[SID103167358]
Km 31TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID679485, Type: other]
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24
[SID103167358]
Km 37.3TP_TRANSPORTER: uptake in OAT-expressing COS-7 cells [AID681015, Type: other]
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25
[SID103167358]
Km 43.2TP_TRANSPORTER: uptake in OAT1-expressing S3 cells [AID680338, Type: other]
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26
[SID103167358]
Km 64.7TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678967, Type: other]
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27
[SID103167358]
Km 70TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681741, Type: other]
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28
[SID103167358]
Km 85.1TP_TRANSPORTER: uptake in Oat1-expressing LLC-PK1 cells [AID681742, Type: other]
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29
[SID103167358]
Km 87.2TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID681141, Type: other]
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30
[SID103167358]
IC50 127TP_TRANSPORTER: inhibition of Urate uptake (Urate: 300 uM) in OAT1-expressing S2 cells [AID679324, Type: other]
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31
[SID103167358]
Ki 301TP_TRANSPORTER: inhibition of E217betaG uptake in Oat3-expressing LLC-PK1 cells [AID679290, Type: other]
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32
[SID103167358]
Km 372TP_TRANSPORTER: uptake in membrane vesicle from MRP1-expressing HeLa cells [AID681077, Type: other]
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33
[SID103167358]
Ki 398TP_TRANSPORTER: inhibition of PCG uptake in Oat3-expressing LLC-PK1 cells [AID679176, Type: other]
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34
[SID103167358]
Ki 446.684Inhibition of mouse Oat6-mediated [3H]ES uptake in Xenopus oocytes after 1 hr [AID360149, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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35
[SID103167358]
Km 880TP_TRANSPORTER: uptake in membrane vesicles from MRP2-expressing HEK cells [AID679663, Type: other]
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36
[SID103167358]
IC50 1300TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681159, Type: other]
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37
[SID103167358]
Ki 1350TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cells [AID679175, Type: other]
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38
[SID103167358]
IC50 4500TP_TRANSPORTER: inhibition of TEA uptake (TEA: 10 uM) in Xenopus laevis oocytes [AID681158, Type: other]
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39
[SID103167358]
 Substrates of transporters of clinical importance in the absorption and dispostion of drugs, OAT1 [AID588964, Type: Literature]Solute carrier family 22 member 6 [gi:74762955]
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40
[SID103167358]
 Activity of mouse Oat6 expressed in Xenopus oocytes assessed as drug uptake [AID360152, Type: Literature]Solute carrier family 22 member 20 [gi:56404586]
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41
[SID103167358]
 Activity of rat recombinant peptidylglycine alpha-amidating monooxygenase assessed as stimulation of oxygen consumption [AID388272, Type: Literature]Peptidyl-glycine alpha-amidating monooxygenase [gi:113705]
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42
[SID103167358]
 Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase [AID388273, Type: Literature]Peptidyl-glycine alpha-amidating monooxygenase [gi:113705]
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43
[SID103167358]
 Ratio of Vm(app) to Km(app) for rat recombinant peptidylglycine alpha-amidating monooxygenase relative to hippuric acid [AID388274, Type: Literature]Peptidyl-glycine alpha-amidating monooxygenase [gi:113705]
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44
[SID103167358]
 Activity of mouse Oat1 expressed in Xenopus oocytes assessed as drug uptake [AID360153, Type: Literature]Solute carrier family 22 member 6 [gi:81901833]
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45
[SID56463545]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID56463545]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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47
[SID103167358]
Km TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678971, Type: other]
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48
[SID103167358]
 TP_TRANSPORTER: uptake in Xenopus laevis oocytes [AID678986, Type: other]
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49
[SID103167358]
 TP_TRANSPORTER: uptake in OAT2-expressing EcR293 cells [AID678961, Type: other]
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50
[SID103167358]
 TP_TRANSPORTER: uptake in OCTN2-expressing HEK293 cells [AID678795, Type: other]
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