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3-(4-fluorophenyl)-7,8-dimethoxy-5-[(3-methylphenyl)methyl]pyrazolo[4,3-c]quinoline (CID 2136917) - Compound BioActivity Data
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BioActivity Outcomes:
Active(65)
 
 
Inactive(706)
 
 
Inconclusive(26)
 
 
Unspecified(10)
 
 
Top Targets:
7tm 4(48)
 
 
 
Bcl-2 like(13)
 
 
 
alkPPc(12)
 
 
Death TRAILR..(12)
 
 
 
 
Tryp SPc(9)
 
 
BioAssay Types:
Screening(560)
 
 
 
 
 
Confirmatory(222)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(47)
 
 
 
 
EC50(17)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 721    Data Row: 807   Total Pages: 41   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14732713]
Potency 0.4654Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID14732713]
Potency 0.5858Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID113635349]
IC50_Mean 1.5SAR analysis of small molecule agonists of the NTR1 receptor in a dose response fluorescent-based calcium flux assay [AID602459, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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4
[SID14732713]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID14732713]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID14732713]
Potency 3.5481Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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7
[SID14732713]
AbsAC40_uM 3.63High Content Cell-Based Imaging Primary HTS to Identify autofluorescent compounds using cells not inducing Measured in Cell-Based System Using Imaging - 7015-02_Activator_Dose_CherryPick_Activity [AID743396, Type: confirmatory]
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8
[SID14732713]
AbsAC40_uM 3.74High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_Dose_CherryPick_Activity [AID743394, Type: confirmatory]
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9
[SID14732713]
IC50 3.924Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID588341, Type: confirmatory]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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10
[SID113635349]
EC50_Mean 4.47SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay [AID588495, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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11
[SID14732713]
IC50 5.428Fluorescence-based cell-based high throughput dose response assay for inhibitors of TLR9-MyD88 binding [AID588340, Type: confirmatory]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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12
[SID113635349]
EC50_Mean 6.07SAR analysis of small molecule NTR1 agonists in a image based GPR35 selectivity assay [AID588503, Type: confirmatory]G-protein coupled receptor 35 [Homo sapiens] [gi:30526188]
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13
[SID113635349]
EC50_Mean 6.34SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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14
[SID126531522]
EC50_Mean 6.55SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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15
[SID14732713]
IC50 7.441Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1) [AID651680, Type: confirmatory]arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2 [Homo sapiens] [gi:351542238]
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16
[SID126531522]
EC50_Mean 9.29SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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17
[SID14732713]
Potency 10VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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18
[SID113635349]
EC50_Mean 10.2SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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19
[SID14732713]
EC50_Mean 16.7Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay counterscreen [AID588502, Type: confirmatory]mRNA interferase toxin, antitoxin is MazE [Escherichia coli str. K-12 substr. MG1655] [gi:16130689]
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20
[SID14732713]
Potency 20.5962A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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