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F1604-0553 (CID 2136907) - Compound BioActivity Data
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BioActivity Outcomes:
Active(73)
 
 
Inactive(696)
 
 
Inconclusive(35)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(19)
 
 
Death TRAILR..(12)
 
 
 
 
alkPPc(12)
 
 
Bcl-2 like(11)
 
 
BioAssay Types:
Screening(563)
 
 
 
 
 
Confirmatory(234)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(153)
 
 
 
 
 
IC50(43)
 
 
 
EC50(26)
 
 
 
 
AC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 731    Data Row: 814   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14735592]
Potency 0.3294Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID14735592]
Potency 0.3696Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID14735592]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID14735592]
EC50_Mean 2.4Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504549, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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5
[SID124384776]
EC50_Mean 3.32SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay [AID588495, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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6
[SID14735592]
Potency 3.9811VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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7
[SID123050385]
EC50_Mean 4.14SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay [AID588495, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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8
[SID14735592]
Potency 4.4668qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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9
[SID14735592]
EC50 4.86Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast [AID1935, Type: confirmatory]
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10
[SID14735592]
Potency 5.0119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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11
[SID14735592]
Potency 5.5911qHTS for inhibitors of Vif-A3G interactions: Cherry picks [AID651812, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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12
[SID14735592]
Potency 5.8048qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID14735592]
Potency 6.3096Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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14
[SID124384776]
EC50_Mean 6.79SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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15
[SID123050385]
EC50_Mean 6.9SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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16
[SID124384776]
EC50_Mean 7.58SAR analysis of small molecule NTR1 agonists in a image based GPR35 selectivity assay [AID588503, Type: confirmatory]G-protein coupled receptor 35 [Homo sapiens] [gi:30526188]
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17
[SID123050385]
EC50_Mean 8.57SAR analysis of small molecule NTR1 agonists in a image based GPR35 selectivity assay [AID588503, Type: confirmatory]G-protein coupled receptor 35 [Homo sapiens] [gi:30526188]
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18
[SID14735592]
Potency 9.9425qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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19
[SID14735592]
Potency 9.9425qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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20
[SID14735592]
EC50 10.377Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to DRD Non-Viral Oncogenic Fibroblast [AID1934, Type: confirmatory]
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21
[SID14735592]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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22
[SID123050385]
EC50_Mean 15SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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23
[SID124384776]
EC50_Mean 15.7SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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24
[SID14735592]
Potency 15.7578qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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25
[SID14735592]
EC50 17.301Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast [AID1936, Type: confirmatory]
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26
[SID14735592]
Potency 19.9526qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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27
[SID14735592]
Potency 31.6228Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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28
[SID14735592]
Single concentration confirmation of inhibitors of Mdm2/MdmX interaction using a Brca1/Bard1 BiLC Counterscreen assay. [AID504668, Type: screening]BRCA1-associated RING domain protein 1 [gi:116241265]
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29
[SID14735592]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin I, cardiac muscle [Homo sapiens] [gi:151101270]
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30
[SID14735592]
Counterscreen for inhibitors of TLR9-MyD88 binding: fluorescence-based cell-based high throughput assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID540251, Type: screening]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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31
[SID14735592]
Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA) [AID624371, Type: screening]Beta lactamase [Pseudomonas aeruginosa] [gi:114881106]
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32
[SID14735592]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624267, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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33
[SID14735592]
Fluorescence-based cell-based high throughput confirmation assay for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and the receptor-interacting serine-threonine kinase 2 (RIPK2) [AID624370, Type: screening]caspase recruitment domain family, member 15 [Homo sapiens] [gi:119603173]
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34
[SID14735592]
HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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35
[SID14735592]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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36
[SID14735592]
Fluorescence-based cell-based high throughput confirmation assay for inhibitors of TLR9-MyD88 binding [AID540250, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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37
[SID123050385]
SAR analysis of small molecule agonists of the NTR1 receptor in a single concentration fluorescent-based calcium flux assay [AID602466, Type: other]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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38
[SID14735592]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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39
[SID14735592]
MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_SinglePoint_HTS_Activity [AID488899, Type: screening]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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40
[SID14735592]
S100A4: HTS Measured in Biochemical System Using Plate Reader - 7045-01_Inhibitor_SinglePoint_HTS_Activity [AID652163, Type: screening]S100A4 [Homo sapiens] [gi:47496637]
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41
[SID14735592]
Fluorescence-based biochemical primary high throughput screening assay to identify activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID493008, Type: screening]troponin T, cardiac muscle isoform 3 [Homo sapiens] [gi:48255881]
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42
[SID14735592]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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43
[SID14735592]
Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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44
[SID14735592]
Primary cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 binding [AID861, Type: screening]toll-like receptor 4 [Homo sapiens] [gi:55662034]
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45
[SID14735592]
Confirmatory cell-based high-throughput screening assay for inhibitors of TLR4-MyD88 binding [AID941, Type: screening]toll-like receptor 4 [Homo sapiens] [gi:55662034]
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46
[SID14735592]
Counterscreen for inhibitors of TLR4-MyD88 binding: a cell-based high-throughput screening assay for inhibitors of beta-lactamase activity [AID1237, Type: screening]toll-like receptor 4 [Homo sapiens] [gi:55662034]
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47
[SID14735592]
Image-Based HTS for Selective Agonists for NTR1 [AID493036, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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48
[SID14735592]
Single concentration confirmation of Image-Based HTS for Selective Agonists for NTR1 [AID504550, Type: screening]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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49
[SID14735592]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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50
[SID14735592]
Single concentration confirmation of uHTS for Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID489028, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
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