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3-(4-fluorophenyl)-5-[(2-fluorophenyl)methyl]-7,8-dimethoxypyrazolo[4,3-c]quinoline (CID 2136890) - Compound BioActivity Data
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BioActivity Outcomes:
Active(45)
 
 
Inactive(488)
 
 
Inconclusive(44)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(41)
 
 
 
 
Bcl-2 like(8)
 
 
G-alpha(8)
 
 
 
Tryp SPc(7)
 
 
alkPPc(6)
 
 
BioAssay Types:
Screening(353)
 
 
 
 
Confirmatory(202)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(146)
 
 
 
 
 
IC50(35)
 
 
 
EC50(10)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 516    Data Row: 578   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24815048]
Potency 0.3696Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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2
[SID24815048]
Potency 0.7375Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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3
[SID24815048]
AbsAC40_uM 1.57High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_Dose_CherryPick_Activity [AID743394, Type: confirmatory]
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4
[SID24815048]
AbsAC40_uM 2.46High Content Cell-Based Imaging Primary HTS to Identify autofluorescent compounds using cells not inducing Measured in Cell-Based System Using Imaging - 7015-02_Activator_Dose_CherryPick_Activity [AID743396, Type: confirmatory]
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5
[SID126531520]
EC50_Mean 2.52SAR analysis of small molecule Agonists NTR1 in a image based assay set 3 [AID602356, Type: confirmatory]neurotensin receptor type 1 [Homo sapiens] [gi:110611243]
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6
[SID24815048]
Potency 2.5929qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID126531520]
EC50_Mean 3.61SAR analysis of small molecule NTR1 agonists in a image based NTR2 selectivity assay set 2 [AID602334, Type: confirmatory]neurotensin receptor type 2 [Homo sapiens] [gi:6912538]
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8
[SID24815048]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24815048]
Potency 5.0119VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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10
[SID24815048]
Potency 6.3096qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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11
[SID24815048]
Potency 6.3096Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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12
[SID24815048]
Potency 7.0795qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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13
[SID24815048]
Potency 8.9125qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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14
[SID24815048]
Potency 9.2A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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15
[SID24815048]
Potency 16.3601qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen [AID651815, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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16
[SID24815048]
Potency 20.5962qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen [AID651813, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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17
[SID24815048]
Potency 25.1189qHTS for Inhibitors of Vif-A3F Interactions: qHTS [AID602313, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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18
[SID24815048]
Fluorescence polarization to screen for inhibitors that disrupt the protein-protein interaction between Keap1 and Nrf2 Measured in Biochemical System Using Plate Reader - 2119-01_Inhibitor_SinglePoint_HTS_Activity [AID504523, Type: screening]kelch-like ECH-associated protein 1 [Homo sapiens] [gi:45269145]
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19
[SID24815048]
Primary screen for compounds that inhibit Alzheimer's amyloid precursor protein (APP) translation [AID1285, Type: screening]amyloid precursor protein, partial [Homo sapiens] [gi:257380]
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20
[SID24815048]
High throughput discovery of novel modulators of ROMK K+ channel activity: Primary Screen [AID1918, Type: screening]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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