3-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid (CID 213329) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(45)
 
 
Inactive(417)
 
 
Inconclusive(23)
 
 
Unspecified(5)
 
 
Top Targets:
Bcl-2 like(17)
 
 
 
alkPPc(16)
 
 
DSPc(10)
 
 
 
7TM GPCR Srx(10)
 
 
Tryp SPc(8)
 
 
BioAssay Types:
Screening(274)
 
 
 
 
Confirmatory(186)
 
 
 
 
Literature(12)
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(95)
 
 
 
 
IC50(45)
 
 
 
 
EC50(20)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 488    Data Row: 490   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4257870]
Potency 1qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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2
[SID4257870]
Potency 1qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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3
[SID4257870]
IC50 1.1257High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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4
[SID4257870]
IC50 1.1257High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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5
[SID4257870]
IC50 1.1257High Throughput Fluorescence Polarization Screen for Bcl-B Phenotype Converters [AID748, Type: confirmatory]nuclear receptor subfamily 4 group A member 1 [Homo sapiens] [gi:27894344]
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6
[SID4257870]
IC50 1.3HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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7
[SID4257870]
IC50 1.3HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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8
[SID4257870]
IC50 1.3HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target [AID521, Type: confirmatory]tyrosine-protein phosphatase non-receptor type 7 isoform 2 [Homo sapiens] [gi:18375660]
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9
[SID4257870]
Potency 1.7783qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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10
[SID4257870]
Potency 1.7783qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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11
[SID4257870]
Potency 1.7783qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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12
[SID4257870]
Potency 4.4668qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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13
[SID4257870]
Potency 7.0795qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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14
[SID4257870]
Potency 8.9125qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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15
[SID4257870]
Potency 10.691qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase [AID485367, Type: confirmatory]ATP-dependent phosphofructokinase [Trypanosoma brucei] [gi:72386991]
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16
[SID103496492]
EC50 11.81Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA [AID413277, Type: Literature]
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17
[SID103496492]
IC50 15Inhibition of Anthrax lethal factor activity by microplate assay [AID269502, Type: Literature]Lethal factor [gi:50402185]
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18
[SID4257870]
IC50 18.5TR-FRET secondary assay for HTS discovery of chemical inhibitors of Hsp70 [AID786, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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19
[SID4257870]
Potency 31.6228qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4 [AID893, Type: confirmatory]Chain A, The Structure Of Wild-Type Human Hadh2 (17beta- Hydroxysteroid Dehydrogenase Type 10) Bound [gi:122921310]
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20
[SID103496492]
IC50 42.23Inhibition of HIV1 3B gp41 six-helix bundle formation after 30 mins by native-polyacrylamide gel electrophoresis [AID413280, Type: Literature]
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21
[SID4257870]
IC50 48.3High Throughput Screening Assay for Hsp70 Inhibitors [AID583, Type: confirmatory]heat shock 70kDa protein 1A [Homo sapiens] [gi:123271505]
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22
[SID4257870]
 In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay [AID551, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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23
[SID4257870]
 In vitro MKP-1 Phosphatase HTS Dose Response Confirmation Assay [AID551, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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24
[SID4257870]
 In vitro Primary HTS Assay for MKP-1 [AID374, Type: screening]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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25
[SID4257870]
 In vitro Primary HTS Assay for MKP-1 [AID374, Type: screening]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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26
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT [AID558, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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27
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of DTT [AID558, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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28
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of Catalase [AID562, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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29
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Effects of Catalase [AID562, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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30
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing [AID563, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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31
[SID4257870]
 In vitro MKP-1 Phosphatase Dose Response Active/Probe Assessment Assay - Reproducibility testing [AID563, Type: confirmatory]dual specificity phosphatase 1 [Homo sapiens] [gi:4758204]
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32
[SID92292052]
 A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities [AID588519, Type: Literature]Chain A, Poliovirus Polymerase With Gtp [gi:52695378]
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33
[SID4257870]
 HIV-1 RT-RNase H MLSCN HTS MH077605 [AID565, Type: screening]Chain A, Hiv-1 Reverse Transcriptase Mol_id: 1; Molecule: Hiv-1 Reverse Transcriptase; Chain: A, B; [gi:1431733]
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34
[SID92292052]
 A screen for compounds that inhibit processive DNA synthesis of vaccinia virus [AID493162, Type: other]DNA polymerase [Vaccinia virus] [gi:335756]
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35
[SID4257870]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. [AID1439, Type: screening]RGS7 [Homo sapiens] [gi:1166512]
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36
[SID4257870]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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37
[SID4257870]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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38
[SID4257870]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions. [AID1504, Type: summary]GNAO1 protein [Homo sapiens] [gi:34190601]
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39
[SID4257870]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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40
[SID4257870]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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41
[SID4257870]
 uHTS of Mcl-1/Bid interaction inhibitors [AID1021, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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42
[SID4257870]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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43
[SID4257870]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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44
[SID4257870]
 uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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45
[SID4257870]
 RNA aptamer-based HTS for inhibitors of GRK2 [AID488847, Type: screening]beta-adrenergic receptor kinase 1 [Homo sapiens] [gi:148539876]
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46
[SID4257870]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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47
[SID4257870]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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48
[SID4257870]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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49
[SID4257870]
 HTS of Estrogen Receptor- alpha Coactivator Binding Potentiators [AID639, Type: screening]Estrogen receptor 1 [Homo sapiens] [gi:118764400]
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50
[SID4257870]
 Multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. [AID1423, Type: screening]guanine nucleotide-binding protein G(o) subunit alpha isoform a [Homo sapiens] [gi:10567816]
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