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Amantadine (CID 2130) - Compound BioActivity Data
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BioActivity Outcomes:
Active(49)
 
 
Inactive(363)
 
 
Inconclusive(51)
 
 
Unspecified(376)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
p450(19)
 
 
 
7TM GPCR Srsx(18)
 
 
 
MFS(14)
 
 
NR LBD ER(9)
 
 
 
BioAssay Types:
Literature(338)
 
 
 
 
 
Confirmatory(288)
 
 
 
 
 
Summary(24)
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(275)
 
 
 
 
IC50(154)
 
 
 
 
EC50(56)
 
 
 
Kd(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 721    Data Row: 839   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189283]
Ki 0.02025Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand [AID204446, Type: other]
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2
[SID103189283]
Kd 0.32Binding affinity to Influenza A Weybridge(H7N7) virus Matrix protein 2 by spectrophotometry [AID489224, Type: Literature]
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3
[SID103189283]
EC50 0.4Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as cell viability by cell-based MTS assay [AID443830, Type: Literature]
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4
[SID103189283]
EC50 0.45Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect [AID718741, Type: Literature]
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5
[SID103189283]
EC50 0.6Antiviral activity against Influenza A virus (A/Taiwan/1/1986(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis [AID733269, Type: Literature]
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6
[SID103189283]
IC50 0.63Antiviral activity against influenza H3N2 virus [AID392529, Type: Literature]
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7
[SID103189283]
EC50 0.8Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as inhibition of virus-induced cytopathic effect by cell-based assay [AID443829, Type: Literature]
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8
[SID103189283]
EC50 1.1Antiviral activity against influenza A H2N2(A2 japan/305/57) in MDCK cells [AID105946, Type: Literature]
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9
[SID103189283]
IC50 1.25In vitro antiinfluenza activity against influenza virus A strain [AID92468, Type: other]
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10
[SID103189283]
EC50 1.9Antiviral activity against Influenza A virus (A/Hong kong/8/1968(H2N3)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis [AID733268, Type: Literature]
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11
[SID103189283]
EC50 1.98Antiviral activity against influenza A/Hong Kong/7/87 (H3N2) in MDCK cells assessed as inhibition of virus-induced cytopathic effect by MTS assay [AID308657, Type: Literature]
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12
[SID103189283]
EC50 2Antiviral activity against amantadine-sensitive Influenza A virus (A/Ned/378/05 (H1N1)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis [AID712810, Type: other]
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13
[SID103189283]
EC50 2Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity by MTS assay [AID536238, Type: Literature]
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14
[SID103189283]
EC50 2Antiviral activity against influenza A virus H3N2 assessed as inhibition of virus-induced cytopathic effect after 72 hrs by MTS assay [AID393162, Type: Literature]
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15
[SID103189283]
IC50 2.22Antiviral activity against Influenza A virus A/HK/8/68(H3N2) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by CCK-8 assay [AID662367, Type: Literature]
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16
[SID103189283]
EC50 2.3Antiviral activity against Influenza A/HK/7/87 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect measured on day 3 post infection by MTS assay [AID693525, Type: Literature]
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17
[SID103189283]
IC50 2.38Antiviral activity against Influenza A virus (A/Vietnam/1194/2004(H5N1)) infected in MDCK cells assessed as inhibition of viral replication by plaque reduction assay [AID647175, Type: Literature]
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18
[SID103189283]
EC50 2.7Antiviral activity against influenza virus A/Hong Kong/7/87 H3N2 in MDCK cells assessed as effect on virus-induced cytopathogenicity by MTS assay [AID388538, Type: Literature]
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19
[SID103189283]
EC50 3.4Antiviral activity against Influenza A virus (A/HK/7/87 (H3N2)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis [AID712814, Type: other]
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20
[SID103189283]
IC50 3.525Inhibition of avian influenza virus H5N1 matrix 2 protein expressed in HEK293 cells assessed as cell viability after 24 hrs [AID480112, Type: Literature]
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21
[SID103189283]
Kd 3.9Binding affinity to Influenza A virus (A/Udorn/72) transmembrane domain of matrix protein 2 (22 to 46) at pH 7.4 by circular dichroism analysis [AID596931, Type: Literature]
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22
[SID103189283]
EC50 4.1Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity after 4 days by colorimetric formazan-based MTS assay [AID658750, Type: Literature]
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23
[SID103189283]
EC50 5Antiviral activity against Influenza A virus H3N2 infected in MDCK cells assessed as reduction visual scoring of virus-induced cytopathogenicity after 4 days [AID658747, Type: Literature]
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24
[SID103189283]
EC50 5.1Antiviral activity against amantadine-sensitive Influenza A virus (A/FM/1/47 (H1N1)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis [AID712809, Type: other]
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25
[SID103189283]
IC50 5.96Antiviral activity against Influenza A virus (A/Hong Kong/8/1968(H2N2)) infected in MDCK cells [AID480113, Type: Literature]
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26
[SID103189283]
EC50 7Antiviral activity against Influenza A virus H3N2 assessed as inhibition of viral induced cytopathic effect [AID478322, Type: Literature]
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27
[SID103189283]
EC50 7.6Antiviral activity against Influenza A/PR/8/34 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect measured on day 3 post infection by MTS assay [AID693524, Type: Literature]
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28
[SID103189283]
IC50 8.8Inhibition of avian influenza virus (H5N1) matrix 2 protein expressed in HEK293 cells by path clamp electrophysiology method [AID480114, Type: Literature]
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29
[SID103189283]
EC50 9.2Antiviral activity against Influenza A virus H3N2 assessed as cell viability by cell based MTS assay [AID478323, Type: Literature]
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30
[SID103189283]
Ki 10.5The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. [AID156805, Type: Literature]
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31
[SID103189283]
EC50 11Antiviral activity against Influenza A virus (A/Ishikawa/7/82 (H3N2)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis [AID712808, Type: other]
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32
[SID103189283]
IC50 16Inhibition of Influenza A virus (A/Udorn/72) wild type matrix protein 2 expressed in xenopus oocytes after 2 mins by two-electrode voltage clamp assay [AID596925, Type: Literature]Matrix protein 2 [gi:123824458]
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33
[SID103189283]
EC50 19Antiviral activity against influenza A virus H1N1 assessed as cell viability by cell based MTS assay [AID478321, Type: Literature]
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34
[SID103189283]
EC50 20Antiviral activity against influenza A virus H1N1 assessed as inhibition of viral induced cytopathic effect [AID478320, Type: Literature]
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35
[SID103189283]
IC50 21.11Antiviral activity against amantadine-sensitive Influenza A virus A/Hong Kong/8/68 (H3N2) infected in MDCK cells assessed as host cell survival after 72 hrs by CCK8 method [AID566968, Type: Literature]
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36
[SID103189283]
EC50 22.5Antiviral activity against influenza A virus A/WSN/33-S31N infected in dog MDCK cells after 2 days by naphthalene black dye staining based plaque reduction assay [AID729292, Type: Literature]
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37
[SID144203619]
Potency 31.6228qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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38
[SID103189283]
IC50 31.983DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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39
[SID103189283]
EC50 35Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) assessed as cell viability by cell-based MTS assay [AID443828, Type: Literature]
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40
[SID103189283]
IC50 37.8Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assay [AID721754, Type: Literature]Multidrug and toxin extrusion protein 1 [gi:74731723]
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41
[SID103189283]
EC50 45Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) assessed as inhibition of virus-induced cytopathic effect by cell-based assay [AID443827, Type: Literature]
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42
[SID48415309]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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43
[SID48415540]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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44
[SID85209575]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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45
[SID103189283]
Antiviral activity against Influenza A virus (A/Udorn/72) expressing wild-type matrix protein 2 infected in MDCK cells assessed as inhibition of plaque formation at 5 uM measured after 2 days [AID596930, Type: Literature]
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46
[SID103189283]
Anti-influenza virus activity was evaluated in Madin-Darby canine kidney (MDCK) cells against influenza A H2N2 strain (A2 Japan/305/57) [AID105963, Type: Literature]
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47
[SID103189283]
Minimum inhibitory concentration required to reduce influenza A H2N2 virus induced cytopathogenicity by 50% in madin-Darby canine kidney cells (MDCK) [AID105967, Type: Literature]
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48
[SID103189283]
Minimum inhibitory concentration required to reduce influenza A H3N2 (X31) virus induced cytopathogenicity by 50% in madin-Darby canine kidney cells (MDCK) [AID105968, Type: Literature]
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49
[SID85860325]
Inhibition of P. falciparum 3D7 [AID2306, Type: screening]L-lactate dehydrogenase [Plasmodium falciparum 3D7] [gi:124513266]
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50
[SID85860325]
XC50_3D7 0.16XC50 for P. falciparum 3D7 [AID2305, Type: confirmatory]
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