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Amantadine (CID 2130) - Compound BioActivity Data
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BioActivity Outcomes:
Active(64)
 
 
Inactive(369)
 
 
Inconclusive(48)
 
 
Unspecified(442)
 
 
Top Targets:
7tm 4(40)
 
 
 
p450(19)
 
 
 
MFS(14)
 
 
NR LBD ER(9)
 
 
 
NR LBD PPAR(8)
 
 
BioAssay Types:
Confirmatory(412)
 
 
 
 
 
Literature(404)
 
 
 
 
 
Summary(24)
 
 
 
Screening(7)
 
 
 
BioActivity Types:
Potency(277)
 
 
 
 
IC50(163)
 
 
 
 
 
EC50(72)
 
 
 
Kd(2)
 
 
Ki(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 804    Data Row: 923   Total Pages: 47   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103189283]
Ki 0.02025Binding affinity towards sigma receptor in guinea pig brain membrane was determined by using [3H]DTG as the radioligand [AID204446, Type: confirmatory]
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2
[SID103189283]
EC50 0.3Antiviral activity against influenza A virus H3N3 subtype infected in dog MDCK cells assessed as reduction of virus-induced cytopathogenicity by MTS assay [AID768188, Type: Literature]
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3
[SID103189283]
Kd 0.32Binding affinity to Influenza A Weybridge(H7N7) virus Matrix protein 2 by spectrophotometry [AID489224, Type: Literature]
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4
[SID103189283]
EC50 0.4Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as cell viability by cell-based MTS assay [AID443830, Type: Literature]
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5
[SID103189283]
EC50 0.45Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) H1N1 infected in MDCK cells assessed as inhibition of virus-induced cytopathic effect [AID718741, Type: Literature]
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6
[SID103189283]
EC50 0.6Antiviral activity against Influenza A virus (A/Taiwan/1/1986(H1N1)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis [AID733269, Type: Literature]
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7
[SID103189283]
IC50 0.63Antiviral activity against influenza H3N2 virus [AID392529, Type: Literature]
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8
[SID103189283]
EC50 0.8Antiviral activity against Influenza A virus H3N3 infected in MDCK cells assessed as reduction in virus-induced cytopathogenicity [AID766686, Type: Literature]
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9
[SID103189283]
EC50 0.8Antiviral activity against Influenza A virus (A/Hong Kong/7/87(H3N2)) assessed as inhibition of virus-induced cytopathic effect by cell-based assay [AID443829, Type: Literature]
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10
[SID103189283]
EC50 0.82Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) harboring wild type M2 channel infected in MDCK cells assessed as reduction of cytopathic effect after 72 hrs by MTS assay [AID1055985, Type: Literature]
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11
[SID103189283]
EC50 0.84Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) harboring wild type M2 channel infected in MDCK cells assessed as reduction of cytopathic effect after 72 hrs by microsocopic analysis [AID1055999, Type: Literature]
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12
[SID103189283]
EC50 1.1Antiviral activity against influenza A H2N2(A2 japan/305/57) in MDCK cells [AID105946, Type: Literature]
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13
[SID103189283]
IC50 1.25In vitro antiinfluenza activity against influenza virus A strain [AID92468, Type: confirmatory]
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14
[SID103189283]
EC50 1.5Antiviral activity against Influenza A virus H3N2 infected MDCK cells assessed as reduction of virus-induced cytopathic effect after 3 days by colorimetric formazan-based MTS assay [AID1113453, Type: confirmatory]
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15
[SID103189283]
EC50 1.9Antiviral activity against Influenza A virus (A/Hong kong/8/1968(H2N3)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity at 1 hr post-infection measured after 3 days by fluorescein-diacetate based fluorimetric analysis [AID733268, Type: Literature]
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16
[SID103189283]
EC50 1.98Antiviral activity against influenza A/Hong Kong/7/87 (H3N2) in MDCK cells assessed as inhibition of virus-induced cytopathic effect by MTS assay [AID308657, Type: Literature]
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17
[SID103189283]
EC50 2Antiviral activity against influenza A virus H3N2 assessed as inhibition of virus-induced cytopathic effect after 72 hrs by MTS assay [AID393162, Type: Literature]
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18
[SID103189283]
EC50 2Antiviral activity against amantadine-sensitive Influenza A virus (A/Ned/378/05 (H1N1)) infected in MDCK cells assessed as virus-induced cytopathic effect measured 3 days post infection by microscopic analysis [AID712810, Type: Literature]
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19
[SID103189283]
EC50 2Antiviral activity against Influenza A virus (A/Hong Kong/7/1987(H3N2)) infected in MDCK cells assessed as inhibition of virus-induced cytopathogenicity by MTS assay [AID536238, Type: Literature]
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20
[SID103189283]
IC50 2.22Antiviral activity against Influenza A virus A/HK/8/68(H3N2) infected in MDCK cells assessed as inhibition of virus-induced cytopathic effects after 3 days by CCK-8 assay [AID662367, Type: Literature]
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