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MLS000054003 (CID 2125057) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(796)
 
 
Inconclusive(15)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(529)
 
 
 
 
Confirmatory(262)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
IC50(50)
 
 
EC50(18)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 758    Data Row: 823   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID99517161]
EC50 0.68297Late stage results for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based cell-based dose response assay for AHR activators [AID493060, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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2
[SID3715992]
EC50 1.537Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID463088, Type: confirmatory]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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3
[SID3715992]
EC50_uM 19.39Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]glycogen synthase kinase-3 beta isoform 1 [Homo sapiens] [gi:21361340]
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4
[SID99517161]
Late stage assay provider counterscreen for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based Human Hepatoma (HG2L7.5c1) Cell-based assay to identify activators of AhR [AID602171, Type: other]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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5
[SID3715992]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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6
[SID3715992]
Inhibitors of Cav3 T-type Calcium Channels: Primary Screen [AID449739, Type: screening]voltage-dependent T-type calcium channel subunit alpha-1H isoform a [Homo sapiens] [gi:53832009]
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7
[SID3715992]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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8
[SID3715992]
CYP2C9 Assay [AID777, Type: screening]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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9
[SID99517161]
Late stage assay provider counterscreen for activators of Aryl hydrocarbon receptor (AHR): Absorbance-based cell-based assay to identify compounds that modulate proliferation of ER-positive breast cancer cells (MCF7) [AID602174, Type: other]
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10
[SID3715992]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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11
[SID3715992]
Luminescence-based cell-based high throughput confirmation assay for activators of the Aryl Hydrocarbon Receptor (AHR) [AID2845, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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12
[SID3715992]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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13
[SID3715992]
Potency 1.4125qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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14
[SID3715992]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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15
[SID3715992]
EC50 116.056Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) [AID463086, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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16
[SID99517161]
EC50 116.135Late stage counterscreen results for the probe development effort to identify activators of the Aryl Hydrocarbon Receptor (AHR): Luminescence-based cell-based dose response assay for activators of the Pregnane X Receptor (PXR) [AID493061, Type: confirmatory]nuclear receptor subfamily 1 group I member 2 isoform 1 [Homo sapiens] [gi:34398348]
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17
[SID3715992]
EC50_uM 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo Reagents [AID434947, Type: confirmatory]
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18
[SID3715992]
IC90 Screen to Identify Novel Compounds That Sensitize Mycobacterium Tuberculosis to Beta-lactam Antibiotics [AID434955, Type: confirmatory]
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19
[SID3715992]
uHTS luminescence assay for the identification of chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation [AID435003, Type: screening]
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20
[SID3715992]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of Beta Cell Apoptosis. [AID435005, Type: screening]
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21
[SID3715992]
uHTS luminescence assay for the identification of chemical inhibitors of B-cell specific antigen receptor-induced NF-kB activation [AID435022, Type: screening]
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22
[SID3715992]
Potency qHTS Assay for Modulators of miRNAs and/orActivators of miR-21 [AID2288, Type: confirmatory]
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23
[SID3715992]
Potency qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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24
[SID3715992]
uHTS identification of small molecules that induce b-cell replication in the MIN-6 cell line [AID2380, Type: screening]
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25
[SID3715992]
IC50 A Cell Based HTS Approach for the Discovery of New Inhibitors of Respiratory syncytial virus (RSV) [AID2391, Type: confirmatory]
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26
[SID3715992]
Potency qHTS Assay for Lipid Storage Modulators in Drosophila S3 Cells [AID2685, Type: confirmatory]
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27
[SID3715992]
A yeast HTS for caloric restriction mimetics that inhibit age-related superoxide [AID2690, Type: screening]
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28
[SID3715992]
Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
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29
[SID3715992]
Luminescence Cell-Based Primary HTS to Identify Transcriptional Activators of Hypoxia-Inducible Factor Pathway [AID1910, Type: screening]
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30
[SID3715992]
384-well Z-Lyte format Hck-Nef inhibitor HTS run at the PMLSC [AID463187, Type: screening]
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31
[SID3715992]
Phenotypic HTS multiplex for antifungal efflux pump inhibitors [AID485275, Type: screening]
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32
[SID3715992]
Potency qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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33
[SID3715992]
Inhibitors of Prion Protein 5' UTR mRNA Measured in Cell-Based System Using Plate Reader - 2078-01_Inhibitor_SinglePoint_HTS_Activity [AID488862, Type: screening]
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34
[SID3715992]
IC50 Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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35
[SID3715992]
IC50 Primary and Confirmatory Screening for Inhibitors of Bacterial Capsule Biogenesis [AID488966, Type: confirmatory]
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36
[SID3715992]
Counterscreen for inhibitors of AddAB: absorbance-based bacterial cell-based high throughput screening assay to identify inhibitors of bacterial viability [AID449728, Type: screening]
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37
[SID3715992]
IC50 High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
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38
[SID3715992]
uHTS identification of small molecule activators of the apoptotic arm of the Unfolded Protein response via a luminescent-based reporter assay [AID449763, Type: screening]
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39
[SID3715992]
HTS to identify inhibitors of TNF-alpha Induced Cell Death in Jurkat FADD-/- Cells. [AID463075, Type: screening]
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40
[SID3715992]
Fluorescence-based counterscreen for orexin 1 receptor (OX1R) antagonists: cell-based assay to identify antagonists of the parental CHO cell line [AID463079, Type: screening]
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41
[SID3715992]
uHTS identification of small molecule activators of the adaptive arm of the Unfolded Protein response via a luminescent-based reporter assay [AID463104, Type: screening]
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42
[SID3715992]
Luminescence Microorganism Primary HTS to Identify Inhibitors of the SUMOylation Pathway Using a Temperature Sensitive Growth Reversal Mutant Mot1-301 [AID2716, Type: screening]
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43
[SID3715992]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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44
[SID3715992]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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45
[SID3715992]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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46
[SID3715992]
Potency Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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47
[SID3715992]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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48
[SID3715992]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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49
[SID3715992]
qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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50
[SID3715992]
Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen [AID598, Type: screening]
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