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MLS001206137 (CID 21231172) - Compound BioActivity Data
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BioActivity Outcomes:
Active(71)
 
 
Inactive(463)
 
 
Inconclusive(44)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(37)
 
 
 
Peptidase C48(11)
 
 
 
Esterase lipa..(8)
 
 
 
TRP 2(5)
 
 
CAP ED(5)
 
 
BioAssay Types:
Screening(391)
 
 
 
 
Confirmatory(177)
 
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(123)
 
 
 
 
 
IC50(32)
 
 
 
EC50(17)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 536    Data Row: 579   Total Pages: 29   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49645303]
EC50_MICROM 2.17Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr2 with Hit compounds from Cherry Pick1 [AID588604, Type: confirmatory]drug resistance protein 2 [Candida albicans] [gi:93115982]
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2
[SID49645303]
AC50_uM 4.37Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity [AID1053173, Type: confirmatory]histone-lysine N-methyltransferase NSD2 isoform 1 [Homo sapiens] [gi:109633019]
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3
[SID49645303]
EC50_MICROM 5.32Dose response compound fluorescence counter screen for HTS for inhibitors of efflux pump with Hit compounds from Cherry Pick1 [AID588620, Type: confirmatory]
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4
[SID49645303]
Potency 5.6234qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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5
[SID49645303]
Potency 7.9433qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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6
[SID49645303]
Potency 8.9125qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID49645303]
IC50_Mean 9.9Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay [AID488904, Type: confirmatory]SUMO1/sentrin specific peptidase 7 [Homo sapiens] [gi:120538355]
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8
[SID49645303]
EC50_MICROM 13.4Dose Response HTS singleplex for inhibitors of yeast efflux pump, specifically Cdr1 with Hit compounds from Cherry Pick1 [AID588606, Type: confirmatory]drug resistance protein 1 [Candida albicans] [gi:93115976]
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9
[SID49645303]
EC50_Mean 13.7Dose response counterscreen for uHTS small molecule activators of the adaptive arm of the Unfolded Protein Response via a luminescent-based reporter assay [AID489027, Type: confirmatory]
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10
[SID49645303]
Potency 15.7578qHTS for inhibitors of Vif-A3F interactions: Cherry picks [AID651814, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3F isoform a [Homo sapiens] [gi:22907044]
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11
[SID49645303]
Potency 15.8489qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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12
[SID49645303]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID49645303]
Potency 18.3564qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID49645303]
Potency 19.0115qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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15
[SID49645303]
Potency 19.9526qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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16
[SID49645303]
Potency 19.9526qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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17
[SID49645303]
IC50 22.31Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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18
[SID49645303]
AbsAC35_uM 22.91ALPHAscreen artifact counterscreen Measured in Biochemical System Using Plate Reader - 7053-03_Inhibitor_Dose_CherryPick_Activity [AID1053174, Type: confirmatory]
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19
[SID49645303]
Potency 23.1093A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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20
[SID49645303]
IC50_Mean 24.3Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay [AID488903, Type: confirmatory]sentrin-specific protease 8 [Homo sapiens] [gi:262118306]
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