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2-(4-morpholinoanilino)-6-cyclohexylaminopurine (CID 210332) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(35)
 
 
Inconclusive(7)
 
 
Unspecified(29)
 
 
Top Targets:
7TM GPCR Srsx(4)
 
 
 
NR LBD ROR li..(2)
 
 
 
SLT beta(2)
 
 
HELICc(2)
 
 
Bromo ALL-1(2)
 
 
 
BioAssay Types:
Literature(54)
 
 
 
 
Confirmatory(32)
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(32)
 
 
 
IC50(8)
 
 
 
Ki(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 88    Data Row: 93   Total Pages: 5   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103457728]
IC50 0.004Inhibition of Mps1 [AID671331, Type: Literature]
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2
[SID103457728]
IC50 0.008Inhibition of MEK1 in mouse C2C12 by ERK2 phosphorylation assay [AID358710, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400275]
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3
[SID103457728]
IC50 0.01Inhibition of ATPase activity of myosin 2 in mouse C2C12 myoblast assessed as release of inorganic phosphates [AID358711, Type: Literature]
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4
[SID103457728]
IC50 0.075Inhibition of Aur B [AID671335, Type: Literature]
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5
[SID103457728]
IC50 0.11Inhibition of Aur A [AID671334, Type: Literature]
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6
[SID87557419]
IC50 0.5Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Aurora B Kinase In Complex With Reversine Inhibitor [gi:210060826]
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7
[SID87557419]
IC50 0.5Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB [AID977608, Type: Literature]Chain A, Crystal Structure Of Aurora B Kinase In Complex With Reversine Inhibitor [gi:210060826]
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8
[SID103457728]
Ki 0.66Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells [AID239225, Type: Literature]Adenosine receptor A3 [gi:1351831]
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9
[SID103457728]
Antagonist activity against human Adenosine A3 receptor [AID238033, Type: Literature]Adenosine receptor A3 [gi:1351831]
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10
[SID103457728]
Reversal of ERK2 phosphorylation in mouse C2C12 at 20 uM in presence of 50 uM LY-294002 after 48 hrs [AID358713, Type: Literature]Mitogen-activated protein kinase 1 [gi:52001076]
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11
[SID103457728]
Reversal of ERK1 phosphorylation in mouse C2C12 myoblast at 20 uM in presence of 50 uM LY-294002 after 48 hrs [AID358712, Type: Literature]Mitogen-activated protein kinase 3 [gi:52001483]
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12
[SID103457728]
Reversal of differentiation of mouse C2C12 myoblasts into osteoblasts at 20 nM in presence of trichostatin A after 48 hrs [AID359558, Type: Literature]
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13
[SID103457728]
Reversal of differentiation of mouse C2C12 myoblasts into adipocytes at 20 nM in presence of trichostatin A after 48 hrs [AID359559, Type: Literature]
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14
[SID103457728]
Induction of cell cycle arrest in mouse C2C12 myoblastss assessed as accumulation at G2/M phase at 20 nM after 48 hrs [AID358724, Type: Literature]
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15
[SID103457728]
Inhibition of MEK-dependent ERK1 phosphorylation in mouse C2C12 cells at 20 nM after 1 hr by Western blot [AID358714, Type: Literature]
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16
[SID103457728]
Inhibition of MEK-dependent ERK2 phosphorylation in mouse C2C12 cells at 20 nM after 1 hr by Western blot [AID358715, Type: Literature]
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17
[SID103457728]
Increase in plasticity in mouse C2C12 myoblasts in presence of 10 ug/mL insulin [AID358704, Type: Literature]
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18
[SID103457728]
Inhibition of cellular apoptosis in presence of 50 uM z-VAD.fmk [AID358705, Type: Literature]
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19
[SID103457728]
Reversal of differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition at 20 nM in presence of PI3K inhibitor LY-294002 after 48 hrs [AID358706, Type: Literature]
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20
[SID103457728]
Reversal of differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition at 20 nM in presence of PI3K inhibitor LY-294002 after 48 hrs [AID358707, Type: Literature]
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