2-(4-morpholinoanilino)-6-cyclohexylaminopurine (CID 210332) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(20)
 
 
Inactive(25)
 
 
Inconclusive(4)
 
 
Unspecified(29)
 
 
Top Targets:
7TM GPCR Srsx(3)
 
 
 
STKc ERK1 2 l..(2)
 
 
RIP(2)
 
 
HELICc(2)
 
 
Menin(2)
 
 
 
BioAssay Types:
Literature(52)
 
 
 
 
Confirmatory(21)
 
 
 
Screening(3)
 
 
BioActivity Types:
Potency(21)
 
 
 
IC50(6)
 
 
 
Ki(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 78    Data Row: 78   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103457728]
IC50 0.004Inhibition of Mps1 [AID671331, Type: Literature]
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2
[SID103457728]
IC50 0.008Inhibition of MEK1 in mouse C2C12 by ERK2 phosphorylation assay [AID358710, Type: Literature]Dual specificity mitogen-activated protein kinase kinase 1 [gi:400275]
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3
[SID103457728]
IC50 0.01Inhibition of ATPase activity of myosin 2 in mouse C2C12 myoblast assessed as release of inorganic phosphates [AID358711, Type: Literature]
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4
[SID103457728]
IC50 0.075Inhibition of Aur B [AID671335, Type: Literature]
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5
[SID103457728]
IC50 0.11Inhibition of Aur A [AID671334, Type: Literature]
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6
[SID103457728]
Ki 0.66Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells [AID239225, Type: Literature]Adenosine receptor A [gi:1351831]
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7
[SID103457728]
Ki 0.66Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells [AID239225, Type: Literature]Adenosine receptor A [gi:1351831]
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8
[SID103457728]
 Antagonist activity against human Adenosine A3 receptor [AID238033, Type: Literature]Adenosine receptor A [gi:1351831]
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9
[SID103457728]
 Antagonist activity against human Adenosine A3 receptor [AID238033, Type: Literature]Adenosine receptor A [gi:1351831]
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10
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into osteoblasts at 20 nM in presence of trichostatin A after 48 hrs [AID359558, Type: Literature]
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11
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into adipocytes at 20 nM in presence of trichostatin A after 48 hrs [AID359559, Type: Literature]
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12
[SID103457728]
 Increase in plasticity in mouse C2C12 myoblasts in presence of 10 ug/mL insulin [AID358704, Type: Literature]
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13
[SID103457728]
 Inhibition of cellular apoptosis in presence of 50 uM z-VAD.fmk [AID358705, Type: Literature]
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14
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition at 20 nM in presence of PI3K inhibitor LY-294002 after 48 hrs [AID358706, Type: Literature]
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15
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition at 20 nM in presence of PI3K inhibitor LY-294002 after 48 hrs [AID358707, Type: Literature]
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16
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition at 20 nM after 48 hrs [AID358708, Type: Literature]
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17
[SID103457728]
 Reversal of differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition at 20 nM after 48 hrs [AID358709, Type: Literature]
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18
[SID103457728]
 Inhibition of MEK-dependent ERK1 phosphorylation in mouse C2C12 cells at 20 nM after 1 hr by Western blot [AID358714, Type: Literature]
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19
[SID103457728]
 Inhibition of MEK-dependent ERK2 phosphorylation in mouse C2C12 cells at 20 nM after 1 hr by Western blot [AID358715, Type: Literature]
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20
[SID103457728]
 Induction of cell cycle arrest in mouse C2C12 myoblastss assessed as accumulation at G2/M phase at 20 nM after 48 hrs [AID358724, Type: Literature]
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21
[SID103457728]
 Reversal of ERK2 phosphorylation in mouse C2C12 at 20 uM in presence of 50 uM LY-294002 after 48 hrs [AID358713, Type: Literature]Mitogen-activated protein kinase 1 [gi:52001076]
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22
[SID103457728]
 Reversal of ERK1 phosphorylation in mouse C2C12 myoblast at 20 uM in presence of 50 uM LY-294002 after 48 hrs [AID358712, Type: Literature]Mitogen-activated protein kinase 3 [gi:52001483]
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23
[SID103457728]
IC50 5Inhibition of PLK1 [AID671336, Type: Literature]
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24
[SID103457728]
Ki 10Percent inhibition of [3H]DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM [AID239050, Type: Literature]Adenosine receptor A [gi:231473]
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25
[SID103457728]
Ki 10Percent inhibition of [3H]DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM [AID239050, Type: Literature]Adenosine receptor A [gi:231473]
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26
[SID103457728]
Ki 10Percent inhibition of [3H]DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM [AID239050, Type: Literature]Adenosine receptor A [gi:231473]
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27
[SID103457728]
Ki 10Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM [AID239392, Type: Literature]Adenosine receptor A2 [gi:543740]
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28
[SID103457728]
Ki 10Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM [AID239392, Type: Literature]Adenosine receptor A2 [gi:543740]
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29
[SID103457728]
Ki 10Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM [AID239392, Type: Literature]Adenosine receptor A2 [gi:543740]
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30
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts at 10 uM under osteoblast-inducing condition assessed as accumulation at G1/S phase [AID358725, Type: Literature]
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31
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts at 10 uM under osteoblast-inducing condition assessed as accumulation at S phase [AID358726, Type: Literature]
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32
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts at 10 uM under osteoblast-inducing condition assessed as accumulation at G2M phase [AID358727, Type: Literature]
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33
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes at 10 uM under adipocyte-inducing condition assessed as accumulation at G1/S phase [AID358728, Type: Literature]
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34
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes at 10 uM under adipocyte-inducing condition assessed as accumulation at S phase [AID358729, Type: Literature]
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35
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes at 10 uM under adipocyte-inducing condition assessed as accumulation at G2/M phase [AID358730, Type: Literature]
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36
[SID103457728]
 Inhibition of myotube formation in mouse C2C12 myoblasts at 20 nM [AID358689, Type: Literature]
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37
[SID103457728]
 Increase in cellular plasticity in mouse C2C12 myoblasts at 20 nM assessed efficiency of osteogenesis under linage-specific inducing condition in absence of drug [AID358690, Type: Literature]
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38
[SID103457728]
 Increase in cellular plasticity in mouse C2C12 myoblasts at 20 nM assessed efficiency of adipogesnesis under linage-specific inducing condition in absence of drug [AID358691, Type: Literature]
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39
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition at 20 nM after 48 hrs [AID358692, Type: Literature]
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40
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition at 20 nM after 48 hrs [AID358693, Type: Literature]
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41
[SID103457728]
 Differentiation of human 3T3E1 osteoblasts into adipocytes under adipocyte-inducing condition at 300 nM after 4 days [AID358696, Type: Literature]
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42
[SID103457728]
 Differentiation of human skeletal myoblasts into osteoblasts under linage-specific inducing condition at 300 nM after 4 days [AID358697, Type: Literature]
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43
[SID103457728]
 Differentiation of human skeletal myoblasts into adipocytes under linage-specific inducing condition at 300 nM after 4 days [AID358698, Type: Literature]
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44
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition in serum free ITS media at 20 uM [AID358699, Type: Literature]
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45
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition in serum free ITS media at 20 uM [AID358700, Type: Literature]
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46
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into osteoblasts under osteoblast-inducing condition in serum containing growth media at 20 uM [AID358701, Type: Literature]
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47
[SID103457728]
 Differentiation of mouse C2C12 myoblasts into adipocytes under adipocyte-inducing condition in serum containing growth media at 20 uM [AID358702, Type: Literature]
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48
[SID103457728]
 Differentiation of MEK1 transfected mouse C2C12 myoblasts into osteoblasts at 20 nM assessed under linage-specific inducing condition in absence of drug [AID358716, Type: Literature]
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49
[SID103457728]
 Differentiation of NMMII transfected mouse C2C12 myoblasts into osteoblasts at 20 nM assessed under linage-specific inducing condition in absence of drug [AID358717, Type: Literature]
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50
[SID103457728]
 Differentiation of mock transfected mouse C2C12 myoblasts into osteoblasts at 20 nM assessed under linage-specific inducing condition in absence of drug [AID358718, Type: Literature]
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