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lapatinib (CID 208908) - Compound BioActivity Data
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BioActivity Outcomes:
Active(324)
 
 
Inactive(458)
 
 
Inconclusive(45)
 
 
Unspecified(1004)
 
 
Top Targets:
PTKc EGFR(48)
 
 
 
PTKc Abl(32)
 
 
 
STKc RSK N(16)
 
 
 
PKc like(15)
 
 
 
PTKc Kit(15)
 
 
 
BioAssay Types:
Literature(1305)
 
 
 
 
 
Confirmatory(491)
 
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(879)
 
 
 
 
IC50(497)
 
 
 
 
Potency(142)
 
 
 
 
Ki(3)
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1587    Data Row: 1831   Total Pages: 92   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103177479]
Kd 0.00092Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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2
[SID103177479]
Kd 0.00092Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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3
[SID103177479]
Kd 0.0012Binding constant for EGFR(L861Q) kinase domain [AID625005, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103177479]
Kd 0.0012Binding constant for EGFR(L861Q) kinase domain [AID435907, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103177479]
IC50 0.002Cytotoxicity against human SKBR3 cells overexpressing HER2 by resazurin dye reduction assay [AID546563, Type: Literature]
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6
[SID103177479]
Kd 0.0021Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103177479]
Kd 0.0021Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103177479]
Kd 0.0022Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID625000, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103177479]
Kd 0.0022Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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10
[SID103177479]
Kd 0.0024Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103177479]
Kd 0.0024Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103177479]
Kd 0.0028Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103177479]
Kd 0.0028Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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14
[SID103177479]
IC50 0.0029Inhibition of EGFR by flash plate based radioactive enzyme assay [AID546551, Type: Literature]
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15
[SID46393564]
Ki 0.003Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Egfr Kinase Domain Complexed With A Quinazoline Inhibitor- Gw572016 [gi:58177366]
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16
[SID46393564]
Ki 0.003Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB [AID977610, Type: Literature]Chain A, Egfr Kinase Domain Complexed With A Quinazoline Inhibitor- Gw572016 [gi:58177366]
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17
[SID103177479]
IC50 0.003Cytotoxicity against human SKOV3 cells overexpressing HER2 by resazurin dye reduction assay [AID546564, Type: Literature]
View
18
[SID103177479]
Kd 0.0035Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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19
[SID103177479]
Kd 0.0035Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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20
[SID103177479]
Kd 0.0039Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View