MLS001110989 (CID 20885163) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inactive(455)
 
 
Inconclusive(5)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
KCNQ channel(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(315)
 
 
 
 
Confirmatory(134)
 
 
 
 
Literature(7)
 
 
BioActivity Types:
Potency(99)
 
 
 
 
IC50(27)
 
 
EC50(6)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 464    Data Row: 464   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49721003]
 Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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2
[SID49721003]
 Luminescence-based cell-based primary high throughput confirmation assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652134, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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3
[SID49721003]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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4
[SID49721003]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the human M1 muscarinic receptor (CHRM1) [AID588852, Type: screening]CHRM1 gene product [Homo sapiens] [gi:37622910]
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5
[SID49721003]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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6
[SID49721003]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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7
[SID49721003]
IC50 67.539Luminescence-based cell-based high throughput dose response assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID687017, Type: confirmatory]NR0B1 gene product [Homo sapiens] [gi:5016090]
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8
[SID49721003]
IC50 67.539Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): Luminescence-based cell-based high throughput dose response assay for nonselective inhibitors/assay artifacts using AP2 mutant SF-1 (NR5A1) Transactivation Assay [AID687018, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
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9
[SID49721003]
IC50 67.539Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): Luminescence-based cell-based high throughput dose response assay for nonselective inhibitors/assay artifacts using AP2 mutant SF-1 (NR5A1) Transactivation Assay [AID687018, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
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10
[SID49721003]
IC50 67.539Counterscreen for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): Luminescence-based cell-based high throughput dose response assay for nonselective inhibitors/assay artifacts using AP2 mutant SF-1 (NR5A1) Transactivation Assay [AID687018, Type: confirmatory]NR5A1 gene product [Homo sapiens] [gi:20070193]
View
11
[SID49721003]
EC50 300Luminescence Cell-Free Homogeneous Counter Screen to Identify Inhibitors of ADP-glo Reagents [AID434947, Type: confirmatory]
View
12
[SID49721003]
EC50 300Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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13
[SID49721003]
EC50 300Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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14
[SID49721003]
EC50 300Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
View
15
[SID49721003]
 Cell-Free Homogeneous Primary HTS to Identify Inhibitors of GSK3beta Activity [AID2097, Type: screening]GSK3B gene product [Homo sapiens] [gi:21361340]
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16
[SID49721003]
 Cell-Free Homogeneous Primary HTS to Identify Inhibitors of GSK3beta Activity [AID2097, Type: screening]GSK3B gene product [Homo sapiens] [gi:21361340]
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17
[SID49721003]
 Cell-Free Homogeneous Primary HTS to Identify Inhibitors of GSK3beta Activity [AID2097, Type: screening]GSK3B gene product [Homo sapiens] [gi:21361340]
View
18
[SID49721003]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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19
[SID49721003]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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20
[SID49721003]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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21
[SID49721003]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID434989, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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22
[SID49721003]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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23
[SID49721003]
 Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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24
[SID49721003]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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25
[SID49721003]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
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26
[SID49721003]
 Luminescence-based primary biochemical high throughput screening assay to identify inhibitors of the Heat Shock Protein 90 (HSP90) [AID1789, Type: screening]HSP90AA1 protein [Homo sapiens] [gi:83318444]
View
27
[SID49721003]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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28
[SID49721003]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
29
[SID49721003]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
30
[SID49721003]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
31
[SID49721003]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
32
[SID49721003]
 Counterscreen for inverse agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify inverse agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504634, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
33
[SID49721003]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify activators of insulin-degrading enzyme (IDE) [AID493087, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View
34
[SID49721003]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
View
35
[SID49721003]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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36
[SID49721003]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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37
[SID49721003]
Potency qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
View
38
[SID49721003]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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39
[SID49721003]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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40
[SID49721003]
Potency qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
41
[SID49721003]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
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42
[SID49721003]
 HTS for Identification of VLA-4 Allosteric Modulators from MLPCN library [AID2557, Type: screening]integrin alpha-4 precursor [Homo sapiens] [gi:67191027]
View
43
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
44
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
45
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
46
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
47
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
48
[SID49721003]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
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49
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
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50
[SID49721003]
 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels [AID2648, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
View