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Albuterol (CID 2083) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(583)
 
 
Inconclusive(69)
 
 
Unspecified(213)
 
 
Top Targets:
7TM GPCR Srsx(42)
 
 
 
 
7TM GPCR Srx(26)
 
 
 
NR LBD ER(17)
 
 
 
 
NR LBD PPAR(16)
 
 
 
NR LBD AR(15)
 
 
 
 
BioAssay Types:
Confirmatory(433)
 
 
 
 
 
Literature(183)
 
 
 
 
 
Summary(49)
 
 
 
Screening(35)
 
 
 
BioActivity Types:
Potency(461)
 
 
 
 
 
IC50(137)
 
 
 
 
 
EC50(7)
 
 
Ki(3)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 569    Data Row: 896   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195118]
EC50 0.000454Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction [AID426234, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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2
[SID103195118]
EC50 0.0091Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as relaxation of carbachol-induced tissue contraction [AID395059, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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3
[SID103195118]
IC50 0.017Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response after 30 mins [AID481519, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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4
[SID103195118]
IC50 0.018Inhibition of spontaneous tone in Guinea pig tracheal spiral strips. [AID76393, Type: Literature]
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5
[SID144203817]
Potency 0.0184qHTS of GLP-1 Receptor Agonists: Hit Validation [AID743262, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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6
[SID103195118]
EC50 0.02512Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay [AID640202, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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7
[SID103195118]
EC50 0.068Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay [AID481517, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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8
[SID103195118]
EC50 0.07586The -logEC50 value of genistein on ACh-precontracted rings, where EC50 is the concentration causing 50% relaxation [AID73691, Type: other]
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9
[SID103195118]
EC50 0.19953Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr [AID606103, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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10
[SID103195118]
EC50 0.268Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against carbachol-induced contraction [AID426144, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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11
[SID103195118]
Kd 0.52Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) [AID40694, Type: Literature]
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12
[SID103195118]
IC50 0.8102DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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13
[SID103195118]
IC50 0.98Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting [AID395056, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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14
[SID103195118]
Kd 1.16Binding affinity to adrenergic beta2 receptor in Hartley guinea pig tracheal ring [AID426241, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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15
[SID103195118]
Ki 1.32Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513154, Type: Literature]
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16
[SID103195118]
Ki 1.828Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay [AID481516, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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17
[SID103195118]
IC50 1.99526Displacement of [3H]dihydroalprenolol from beta2-adrenoceptor after 90 mins by liquid scintillation counting [AID640201, Type: Literature]
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18
[SID103195118]
Ki 2.14Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513146, Type: Literature]
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19
[SID103195118]
Agonist activity at beta-2-adrenergic receptor expressed in HEK293 cells assessed as induction of receptor interaction with beta-arrestin by EYFP based reporter gene assay [AID503294, Type: Literature]
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20
[SID85209279]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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21
[SID103195118]
Selectivity for beta-2 adrenergic receptor [AID41488, Type: Literature]
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22
[SID103195118]
Tested for intrinsic sympathomimetic activity (ISA); Agonist [AID41888, Type: Literature]
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23
[SID48414441]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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24
[SID48414441]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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25
[SID48415524]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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26
[SID103195118]
Apparent binding affinity constant to beta-2 adrenergic receptor determined using [3H]DHA [AID40687, Type: Literature]Beta-2 adrenergic receptor [gi:2851541]
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27
[SID103195118]
Concentration required for maximal (95-100%) beta-2 adrenergic receptor occupancy [AID40688, Type: Literature]Beta-2 adrenergic receptor [gi:2851541]
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28
[SID103195118]
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as maximum bronchorelaxation activity against histamine-induced contraction at 100 uM [AID426237, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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29
[SID103195118]
Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as maximum bronchorelaxation activity against carbachol-induced contraction at 100 uM [AID426238, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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30
[SID17405646]
Modulators of the EP2 prostaglandin E2 receptor - Primary Screening [AID940, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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31
[SID103195118]
Beta-2 adrenergic receptor agonist [AID742548, Type: other]Beta-2 adrenergic receptor [gi:296439450]
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32
[SID103195118]
DRUGMATRIX: CYP450, 2A6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625246, Type: other]Cytochrome P450 2A6 [gi:308153612]
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33
[SID103195118]
IC50 DRUGMATRIX: Opiate delta1 (OP1, DOP) radioligand binding (ligand: [3H] Naltrindole) [AID625161, Type: other]Delta-type opioid receptor [gi:311033488]
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34
[SID103195118]
Intrinsic activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr relative to formoterol [AID606104, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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35
[SID103195118]
Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay relative to formoterol [AID481518, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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36
[SID103195118]
IC50 DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968) [AID625227, Type: other]Substance-K receptor [gi:229462950]
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37
[SID103195118]
IC50 DRUGMATRIX: Leukotriene LTC4 Synthase enzyme inhibition (substrate: LTA4) [AID625144, Type: other]Leukotriene C4 synthase [gi:239977155]
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38
[SID103195118]
IC50 DRUGMATRIX: Thromboxane Synthetase enzyme inhibition (substrate: PGH2) [AID625229, Type: other]Thromboxane-A synthase [gi:254763392]
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39
[SID103195118]
IC50 DRUGMATRIX: Protease, Matrix Metalloprotease-9 (MMP-9) enzyme inhibition (substrate: Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2) [AID625178, Type: other]Matrix metalloproteinase-9 [gi:269849668]
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40
[SID103195118]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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41
[SID103195118]
DRUGMATRIX: Chemokine CXCR1 (IL-8A) [AID625240, Type: other]C-X-C chemokine receptor type 1 [gi:108936015]
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42
[SID103195118]
IC50 DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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43
[SID103195118]
IC50 DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
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44
[SID103195118]
IC50 DRUGMATRIX: Vascular Endothelinal Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) [AID625231, Type: other]Vascular endothelial growth factor receptor 1 [gi:143811474]
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45
[SID103195118]
IC50 DRUGMATRIX: Phosphodiesterase PDE5 enzyme inhibition (substrate: [3H]cGMP + cGMP) [AID625167, Type: other]cGMP-specific 3',5'-cyclic phosphodiesterase [gi:317373261]
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46
[SID103195118]
IC50 DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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47
[SID103195118]
DRUGMATRIX: Protein Serine/Threonine Kinase PKCalpha enzyme inhibition (substrate: Histone) [AID625179, Type: other]Protein kinase C alpha type [gi:317373571]
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48
[SID103195118]
IC50 DRUGMATRIX: Melanocortin MC3 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625147, Type: other]Melanocortin receptor 3 [gi:395398606]
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49
[SID103195118]
DRUGMATRIX: Calcitonin radioligand binding (ligand: [125I] Calcitonin (salmon)) [AID625214, Type: other]Calcitonin receptor [gi:550544247]
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50
[SID50104505]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
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