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Albuterol (CID 2083) - Compound BioActivity Data
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BioActivity Outcomes:
Active(31)
 
 
Inactive(595)
 
 
Inconclusive(61)
 
 
Unspecified(217)
 
 
Top Targets:
7TM GPCR Srsx(42)
 
 
 
 
7TM GPCR Srx(26)
 
 
 
NR LBD ER(17)
 
 
 
 
NR LBD PPAR(16)
 
 
NR LBD AR(15)
 
 
 
 
BioAssay Types:
Confirmatory(553)
 
 
 
 
 
Literature(190)
 
 
 
 
 
Summary(49)
 
 
 
Screening(35)
 
 
 
BioActivity Types:
Potency(465)
 
 
 
 
 
IC50(137)
 
 
 
 
 
EC50(7)
 
 
Ki(3)
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 574    Data Row: 904   Total Pages: 46   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195118]
EC50 0.000454Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against histamine-induced contraction [AID426234, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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2
[SID103195118]
EC50 0.0091Agonist activity at adrenergic beta2 receptor in guinea pig trachea assessed as relaxation of carbachol-induced tissue contraction [AID395059, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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3
[SID103195118]
IC50 0.017Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response after 30 mins [AID481519, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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4
[SID103195118]
IC50 0.018Inhibition of spontaneous tone in Guinea pig tracheal spiral strips. [AID76393, Type: Literature]
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5
[SID144203817]
Potency 0.0184qHTS of GLP-1 Receptor Agonists: Hit Validation [AID743262, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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6
[SID103195118]
EC50 0.02512Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay [AID640202, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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7
[SID103195118]
EC50 0.068Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay [AID481517, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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8
[SID103195118]
EC50 0.07586The -logEC50 value of genistein on ACh-precontracted rings, where EC50 is the concentration causing 50% relaxation [AID73691, Type: confirmatory]
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9
[SID103195118]
EC50 0.19953Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr [AID606103, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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10
[SID103195118]
EC50 0.268Agonist activity at adrenergic beta2 receptor in Hartley guinea pig tracheal ring assessed as bronchorelaxation activity against carbachol-induced contraction [AID426144, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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11
[SID103195118]
Kd 0.52Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) [AID40694, Type: Literature]
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12
[SID103195118]
IC50 0.8102DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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13
[SID103195118]
IC50 0.98Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting [AID395056, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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14
[SID103195118]
Kd 1.16Binding affinity to adrenergic beta2 receptor in Hartley guinea pig tracheal ring [AID426241, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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15
[SID103195118]
Ki 1.32Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513154, Type: Literature]
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16
[SID103195118]
Ki 1.828Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay [AID481516, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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17
[SID103195118]
IC50 1.99526Displacement of [3H]dihydroalprenolol from beta2-adrenoceptor after 90 mins by liquid scintillation counting [AID640201, Type: Literature]
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18
[SID103195118]
Ki 2.14Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513146, Type: Literature]
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19
[SID103195118]
Agonist activity at beta-2-adrenergic receptor expressed in HEK293 cells assessed as induction of receptor interaction with beta-arrestin by EYFP based reporter gene assay [AID503294, Type: Literature]
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20
[SID103195118]
Selectivity for beta-2 adrenergic receptor [AID41488, Type: Literature]
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