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BioActivity Data for Compound Albuterol (CID 2083)

BioActivity Outcomes:
Active(29)
 
 
Inactive(639)
 
 
Inconclusive(60)
 
 
Unspecified(268)
 
 
Top Targets:
7tm 4(72)
 
 
 
 
NR LBD ER(17)
 
 
 
 
NR LBD PPAR(16)
 
 
NR LBD AR(15)
 
 
 
p450(12)
 
 
 
BioAssay Types:
Confirmatory(580)
 
 
 
 
 
Literature(232)
 
 
 
 
 
Summary(59)
 
 
 
Screening(43)
 
 
 
BioAssay Categories:
In vitro(143)
 
 
 
 
In vivo(16)
 
 
 
Biochemical(172)
 
 
 
 
Toxicity(46)
 
 
 
 
ADME(61)
 
 
Cell-based(125)
 
 
 
 
 
Organism-base..(2)
 
 
BioActivity Types:
Potency(496)
 
 
 
 
 
IC50(137)
 
 
 
 
 
EC50(7)
 
 
 
AC50(6)
 
 
 
Ki(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 651    Data Row: 996   Total Pages: 50   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103195118]
IC50 0.017Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response after 30 mins [AID481519, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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2
[SID103195118]
IC50 0.018Inhibition of spontaneous tone in Guinea pig tracheal spiral strips. [AID76393, Type: Literature]
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3
[SID144203817]
Potency 0.0184qHTS of GLP-1 Receptor Agonists: Hit Validation [AID743262, Type: confirmatory]glp-1 receptor, partial [Homo sapiens] [gi:1724069]
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4
[SID103195118]
EC50 0.02512Agonist activity at recombinant human beta2-adrenoceptor expressed in whole cells assessed as cAMP accumulation by homogeneous radioimmunoassay [AID640202, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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5
[SID103195118]
EC50 0.068Agonist activity at human beta2 adrenergic receptor assessed as increase in cAMP level by whole cell assay [AID481517, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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6
[SID103195118]
EC50 0.07586The -logEC50 value of genistein on ACh-precontracted rings, where EC50 is the concentration causing 50% relaxation [AID73691, Type: confirmatory]
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7
[SID103195118]
EC50 0.19953Agonist activity at human adrenergic beta2 receptor expressed in H292 cells assessed as intracellular cAMP accumulation after 1 hr [AID606103, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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8
[SID103195118]
Kd 0.52Affinity for cow beta-2 adrenergic receptor by measuring displacement (-)-[3H]dihydroalprenolol (DHA) [AID40694, Type: Literature]
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9
[SID103195118]
IC50 0.8102DRUGMATRIX: Adrenergic beta2 radioligand binding (ligand: [3H] CGP-12177) [AID625205, Type: confirmatory]Beta-2 adrenergic receptor [gi:296439450]
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10
[SID103195118]
Kd 1.16Binding affinity to adrenergic beta2 receptor in Hartley guinea pig tracheal ring [AID426241, Type: Literature]Beta-2 adrenergic receptor [gi:81914759]
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11
[SID103195118]
Ki 1.32Binding affinity to human beta-2 adrenergic receptor delta 5-C271/W135 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513154, Type: Literature]
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12
[SID103195118]
Ki 1.828Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assay [AID481516, Type: Literature]Beta-2 adrenergic receptor [gi:296439450]
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13
[SID103195118]
IC50 1.99526Displacement of [3H]dihydroalprenolol from beta2-adrenoceptor after 90 mins by liquid scintillation counting [AID640201, Type: Literature]
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14
[SID103195118]
Ki 2.14Binding affinity to human beta-2 adrenergic receptor delta 5-C271 mutant expressed in Spodoptera frugiperda Sf9 cells [AID513146, Type: Literature]
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15
[SID103195118]
Agonist activity at beta-2-adrenergic receptor expressed in HEK293 cells assessed as induction of receptor interaction with beta-arrestin by EYFP based reporter gene assay [AID503294, Type: Literature]
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16
[SID170465034]
HCT116 viability from Cell TiterGlo-screen [AID1117342, Type: screening]
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17
[SID48415524]
DSSTox (FDAMDD) FDA Maximum (Recommended) Daily Dose Database [AID1195, Type: other]
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18
[SID48414441]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results [AID1189, Type: other]
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19
[SID48414441]
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Rat Bioassay Results [AID1208, Type: other]
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20
[SID85209279]
Ligands of bioamine (Class A) GPCRs [AID2062, Type: other]
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