Carbenicillin (CID 20824) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(4)
 
 
Inactive(3)
 
 
Inconclusive(1)
 
 
Unspecified(283)
 
 
Top Targets:
Beta-lactamas..(1)
 
 
Lactamase B(1)
 
 
MFS(1)
 
 
NAD binding 8(1)
 
 
BioAssay Types:
Literature(290)
 
 
 
 
 
BioActivity Types:
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 291    Data Row: 291   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103367425]
Km 17Activity of Brachyspira pilosicoli beta-lactamase OXA-63 expressed in Escherichia coli BL21 (DE3) assessed as compound hydrolysis by spectrophotometry [AID519631, Type: Literature]
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2
[SID103367425]
MIC 20Antibacterial activity against Escherichia coli K12 [AID275061, Type: Literature]
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3
[SID103367425]
Km 30Activity at Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menton equation [AID562337, Type: Literature]Metallo-beta-lactamase IND-6 [gi:122301284]
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4
[SID103367425]
 Antibacterial activity against Pseudomonas aeruginosa PAO1 assessed as inhibition of bacterial population at 64 ug/ml after 48 hrs [AID325474, Type: Literature]
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5
[SID103367425]
Km 75Activity of Escherichia coli beta-lactamase VIM-1 by spectrophotometry [AID531317, Type: Literature]
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6
[SID103367425]
Km 84Activity of Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry [AID531313, Type: Literature]
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7
[SID103367425]
Km 205Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry [AID531315, Type: Literature]Metallo beta-lactamase (VIM-2 protein) (Metallo-beta-lactamase VIM-2) (Mettalo-beta-lactamase VIM-2) [gi:75532691]
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8
[SID103367425]
Km 205Activity of Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry [AID531315, Type: Literature]Metallo beta-lactamase (VIM-2 protein) (Metallo-beta-lactamase VIM-2) (Mettalo-beta-lactamase VIM-2) [gi:75532691]
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9
[SID103367425]
Km 245Activity of Carnobacterium divergens BM4489 penicillinase Cad-1 assessed as initial rate of hydrolysis by spectrophotometer [AID422496, Type: Literature]
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10
[SID103367425]
Km 320Activity of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis [AID340736, Type: Literature]
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11
[SID103367425]
Ki 500TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes [AID678786, Type: other]Solute carrier family 22 member 6 [gi:81886651]
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12
[SID103367425]
 Activity of Escherichia coli K12 beta-lactamase TEM1 relative to penicillin G [AID326272, Type: Literature]Beta-lactamase TEM [gi:50401825]
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13
[SID103367425]
 Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis [AID340737, Type: Literature]
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14
[SID103367425]
 Ratio of Kcat to Km of Chryseobacterium indologenes metallo-beta-lactamase IND-5 expressed in Escherichia coli BL21(DE3) assessed as substrate hydrolysis relative to control [AID340738, Type: Literature]
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15
[SID103367425]
 Ratio of MIC for wild type Salmonella typhimurium SH5014 to MIC for Salmonella typhimurium SH7616 harboring missense mutation in acrA/acrB gene by two-fold serial dilution method [AID660263, Type: Literature]
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16
[SID103367425]
 Ratio of MIC for wild type Escherichia coli TG1 to MIC for acrB-deficient Escherichia coli KAM3 by two-fold serial dilution method [AID660262, Type: Literature]
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17
[SID103367425]
 Ratio of MIC for wild type Escherichia coli JC7623 to MIC for acrAB-deficient Escherichia coli JZM120 [AID660261, Type: Literature]
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18
[SID103367425]
 Ratio of Kcat to Km for Chryseobacterium meningosepticum CCUG 4310 beta-lactamase BlaB1 expressed in Escherichia coli DH5alpha by Michaelis-Menton equation [AID562341, Type: Literature]Carbapenem-hydrolyzing beta-lactamase BlaB-1 [gi:30172763]
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19
[SID103367425]
 Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-5 expressed in Escherichia coli DH5alpha by Michaelis-Menton equation [AID562339, Type: Literature]IND-like metallo-beta-lactamase [gi:75460210]
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20
[SID103367425]
 Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry [AID531316, Type: Literature]Metallo beta-lactamase (VIM-2 protein) (Metallo-beta-lactamase VIM-2) (Mettalo-beta-lactamase VIM-2) [gi:75532691]
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21
[SID103367425]
 Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-2 by spectrophotometry [AID531316, Type: Literature]Metallo beta-lactamase (VIM-2 protein) (Metallo-beta-lactamase VIM-2) (Mettalo-beta-lactamase VIM-2) [gi:75532691]
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22
[SID103367425]
 Ratio of Kcat to Km for Pseudomonas aeruginosa beta-lactamase VIM-7 by spectrophotometry [AID531314, Type: Literature]
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23
[SID103367425]
 Ratio of Kcat to Km for Chryseobacterium indologenes 597 metallo-beta-lactamase IND-6 expressed in Escherichia coli DH5alpha by Michaelis-Menton equation [AID562338, Type: Literature]Metallo-beta-lactamase IND-6 [gi:122301284]
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24
[SID103367425]
 Antibacterial activity against MBX-1090-resistant Staphylococcus aureus isolate d20A1 after 16 to 20 hrs by broth microdilution method [AID477411, Type: Literature]
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25
[SID103367425]
 Antibacterial activity against Staphylococcus aureus NCTC 8325 after 16 to 20 hrs by broth microdilution method [AID477409, Type: Literature]
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26
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 3149 from fibrosis patient by Etest [AID523513, Type: Literature]
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27
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 12102 from fibrosis patient by Etest [AID523514, Type: Literature]
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28
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 1253 from fibrosis patient by Etest [AID523515, Type: Literature]
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29
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 13120 from fibrosis patient by Etest [AID523516, Type: Literature]
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30
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 1665 from fibrosis patient by Etest [AID523517, Type: Literature]
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31
[SID103367425]
 Antimicrobial activity against Pseudomonas aeruginosa isolate 17112 from fibrosis patient by Etest [AID523518, Type: Literature]
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32
[SID103367425]
 Antibacterial activity against Escherichia coli NKE96 harboring deletion mutation in acrB protein [AID524260, Type: Literature]
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33
[SID103367425]
 Antibacterial activity against Escherichia coli NKE154 harboring vector expressing acrB deletion mutant [AID524261, Type: Literature]
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34
[SID103367425]
 Antibacterial activity against Escherichia coli NKE155 harboring deletion mutation in acrB protein and plasmid expressing nlpE gene [AID524262, Type: Literature]
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35
[SID103367425]
 Antibacterial activity against Escherichia coli NKE127 harboring deletion mutation in acrB and cpxAR protein [AID524263, Type: Literature]
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36
[SID103367425]
 Antibacterial activity against Escherichia coli NKE158 harboring deletion mutation in acrB protein and vector expressing cpxAR gene [AID524264, Type: Literature]
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37
[SID103367425]
 Antibacterial activity against Escherichia coli NKE159 harboring deletion mutation in acrB, cpxAR protein and plasmid expressing nlpE gene [AID524265, Type: Literature]
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38
[SID103367425]
 Antibacterial activity against Escherichia coli NKE128 harboring deletion mutation in acrB and tolC protein [AID524266, Type: Literature]
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39
[SID103367425]
 Antibacterial activity against Escherichia coli NKE160 harboring deletion mutation in acrB protein and vector expressing tolC gene [AID524382, Type: Literature]
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40
[SID103367425]
 Antibacterial activity against Escherichia coli NKE161 harboring deletion mutation in acrB protein, vector expressing tolC gene and plasmid expressing nlpE gene [AID524383, Type: Literature]
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41
[SID103367425]
 Antibacterial activity against Escherichia coli NKE126 harboring deletion mutation in acrB and acrD protein [AID524384, Type: Literature]
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42
[SID103367425]
 Antibacterial activity against Escherichia coli NKE156 harboring deletion mutation in acrB protein and vector expressing acrD gene [AID524385, Type: Literature]
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43
[SID103367425]
 Antibacterial activity against Escherichia coli NKE157 harboring deletion mutation in acrB, acrD protein and plasmid expressing nlpE gene [AID524386, Type: Literature]
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44
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1365 harboring deletion mutation in acrB and mdtABC protein [AID524387, Type: Literature]
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45
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1366 harboring deletion mutation in acrB and vector expressing mdtABC gene [AID524388, Type: Literature]
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46
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1367 harboring deletion mutation in acrB, mdtABC protein and plasmid expressing nlpE gene [AID524389, Type: Literature]
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47
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1316 harboring deletion mutation in acrB, acrD and mdtABC protein [AID524390, Type: Literature]
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48
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1368 harboring deletion mutation in acrB, acrD and vector expressing mdtABC gene [AID524391, Type: Literature]
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49
[SID103367425]
 Antibacterial activity against Escherichia coli NKE1369 harboring deletion mutation in acrB, acrD, mdtABC protein and plasmid expressing nlpE gene [AID524392, Type: Literature]
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50
[SID103367425]
 Antibacterial activity against Pseudomonas aeruginosa 100609 after 20 hrs by broth microdilution assay [AID529159, Type: Literature]
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